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    Method for less invasive knee resection
    3.
    发明授权
    Method for less invasive knee resection 有权
    低侵入性膝关节切除术的方法

    公开(公告)号：US08870883B2

    公开(公告)日：2014-10-28

    申请号：US13016774

    申请日：2011-01-28

    申请人： Robert Metzger ,  Stephen Brown ,  Garrett A. Sheffer

    发明人： Robert Metzger ,  Stephen Brown ,  Garrett A. Sheffer

    IPC分类号： A61B17/56 ,  A61B17/15 ,  A61B17/14 ,  A61B17/02

    CPC分类号： A61B17/155 ,  A61B17/02 ,  A61B17/14 ,  A61B17/142 ,  A61B17/157

    摘要： Various method and apparatuses may be used to perform a procedure, such as a resection of a portion of the anatomy for preparation of the implants of a prosthetic. Various resecting member, including saw blades having selected geometries and shapes, can be used to assist in the resection of an anatomy to provide for implantation of a prosthetic. In addition, a cutting block assembly may be used to guide the resecting member. The cutting block assembly may be moveably mounted relative to the portion to be resected.

    摘要翻译： 可以使用各种方法和装置来执行手术，例如切除解剖结构的一部分以准备假体的植入物。 可以使用包括具有选定几何形状和形状的锯片的各种切除构件来辅助切除解剖结构以提供假体植入。 此外，可以使用切割块组件来引导切除部件。 切割块组件可相对于要切除的部分可移动地安装。

    Recombinant microorganisms for production C4-dicarboxylic acids
    4.
    发明授权
    Recombinant microorganisms for production C4-dicarboxylic acids 失效
    用于生产C4-二羧酸的重组微生物

    公开(公告)号：US08663956B2

    公开(公告)日：2014-03-04

    申请号：US13588322

    申请日：2012-08-17

    申请人： Sarah McFarland ,  Stephen Brown ,  Sheryl Luttringer

    发明人： Sarah McFarland ,  Stephen Brown ,  Sheryl Luttringer

    IPC分类号： C12N1/15

    CPC分类号： C12N15/8243 ,  C12N9/88

    摘要： Provided herein are host cells comprising carbonic anhydrase activity, wherein the cells are capable of producing C4-dicarboxylic acid. Also provided are methods of producing C4-dicarboxylic acid comprising (a) cultivating the host cells having carbonic anhydrase activity in a medium under suitable conditions to produce C4-dicarboxylic acid; and (b) recovering the C4-dicarboxylic acid.

    摘要翻译： 本文提供了包含碳酸酐酶活性的宿主细胞，其中细胞能够产生C4-二羧酸。 还提供了生产C4-二羧酸的方法，其包括（a）在合适条件下培养在培养基中具有碳酸酐酶活性的宿主细胞以产生C4-二羧酸; 和（b）回收C4-二羧酸。

    Methods for producing hyaluronan in a recombinant host cell
    6.
    发明授权
    Methods for producing hyaluronan in a recombinant host cell 有权
    在重组宿主细胞中产生透明质酸的方法

    公开(公告)号：US08574886B2

    公开(公告)日：2013-11-05

    申请号：US13401663

    申请日：2012-02-21

    申请人： Regine Behr ,  William Widner ,  Maria Tang ,  Stephen Brown ,  Leslie Naggiar ,  Linda Sternberg

    发明人： Alan Sloma ,  Regine Behr ,  William Widner ,  Maria Tang ,  David Sternberg ,  Stephen Brown

    IPC分类号： C12N1/20 ,  C12N15/74 ,  C12N15/00 ,  C12P19/04 ,  C12P19/26 ,  C12P19/28 ,  C12P1/00 ,  C12P21/06 ,  C07H21/04

    CPC分类号： C12P19/26 ,  C12N9/1051 ,  C12N15/52

    摘要： The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a UDP-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a UDP-glucose pyrophosphorylase gene, UDP-N-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene. The present invention also relates to isolated nucleic acid sequences encoding a UDP-glucose 6-dehydrogenase, UDP-glucose pyrophosphorylase, and UDP-N-acetylglucosamine pyrophosphorylase.

    摘要翻译： 本发明涉及透明质酸的制备方法，其包括：（a）在适于产生透明质酸的条件下培养芽孢杆菌属宿主细胞，其中所述芽孢杆菌宿主细胞包含可操作地连接的透明质酸合酶编码序列的核酸构建体 涉及透明质酸合酶编码序列外源的启动子序列; 和（b）从培养基中回收透明质酸。 本发明还涉及编码包含透明质酸合酶基因和UDP-葡萄糖-6-脱氢酶基因的透明质酸合酶操纵子的分离的核酸序列，以及任选地一种或多种选自UDP-葡萄糖焦磷酸化酶基因， UDP-N-乙酰葡糖胺焦磷酸化酶基因和葡萄糖-6-磷酸异构酶基因。 本发明还涉及编码UDP-葡萄糖-6-脱氢酶，UDP-葡萄糖焦磷酸化酶和UDP-N-乙酰葡糖胺焦磷酸化酶的分离的核酸序列。

    EXPANDABLE THORACIC ACCESS PORT
    7.
    发明申请
    EXPANDABLE THORACIC ACCESS PORT 失效
    可扩展的THORACIC访问端口

    公开(公告)号：US20120041269A1

    公开(公告)日：2012-02-16

    申请号：US13166878

    申请日：2011-06-23

    申请人： Thomas John Hector Copeland ,  Cormac O'Prey ,  Rebecca Ann Wilkins ,  Daniel Leonard Fuller ,  Stephen Brown ,  Christopher John Silk ,  Trevor Beckett

    发明人： Thomas John Hector Copeland ,  Cormac O'Prey ,  Rebecca Ann Wilkins ,  Daniel Leonard Fuller ,  Stephen Brown ,  Christopher John Silk ,  Trevor Beckett

    IPC分类号： A61B1/32

    CPC分类号： A61B17/0218 ,  A61B17/3423 ,  A61B17/3431 ,  A61B17/3439 ,  A61B2017/0225 ,  A61B2017/3427 ,  A61B2017/3488

    摘要： A surgical access assembly for positioning within an opening in tissue including an outer member positionable outside a patient and defining an opening therein to receive a surgical instrument. The outer member has a first portion and a second portion wherein at least one of the first and second portions is movable with respect to the other portion. The assembly also includes an inner member positionable within a patient and a flexible member extending between the inner member and outer member, wherein movement of one of the first and second portions of the outer member adjusts tension on the flexible member to retract tissue. A locking mechanism locks the outer member in a plurality of select expanded positions. The locking mechanism includes first engagement structure on the first portion engageable with the second portion and a slidable member movable to a locking position to retain the first and second portions in the select expanded position.

    摘要翻译： 一种用于定位在组织中的开口内的外科进入组件，包括可定位在患者外部并在其中限定其中的开口以接收外科器械的外部构件。 外部构件具有第一部分和第二部分，其中第一和第二部分中的至少一个可相对于另一部分移动。 组件还包括可定位在患者体内的内部构件和在内部构件和外部构件之间延伸的柔性构件，其中外部构件的第一和第二部分中的一个的运动调节柔性构件上的张力以缩回组织。 锁定机构将外部构件锁定在多个选择的扩张位置。 锁定机构包括可与第二部分接合的第一部分上的第一接合结构和可移动到锁定位置以将第一和第二部分保持在选择扩张位置的可滑动构件。

    Enhanced Terrestrial Mobile Location
    10.
    发明申请
    Enhanced Terrestrial Mobile Location 有权
    增强的地面移动位置

    公开(公告)号：US20090075651A1

    公开(公告)日：2009-03-19

    申请号：US11887948

    申请日：2006-04-10

    申请人： Malcolm MacNaughtan ,  Christopher Ridgway Drane ,  Craig Andrew Scott ,  Stephen Brown

    发明人： Malcolm MacNaughtan ,  Christopher Ridgway Drane ,  Craig Andrew Scott ,  Stephen Brown

    IPC分类号： H04W4/00

    CPC分类号： H04W64/00 ,  G01S5/0036 ,  G01S5/0252 ,  G01S5/14

    摘要： Methods and systems for determining whether a mobile radio terminal is on or out of a zone in a radio communications network. The methods and systems provide for generating a profile representative of the zone using measurements taken by the mobile radio terminal and/or the network and/or using predicted values. A comparison is then made between subsequent measurements or values and the profile to make a determination as to whether the mobile radio terminal is in or out of the zone. The methods and systems are applicable to any zone-based application including differential call charging, security applications, buddy finder services, mobile gaming and location based services in general.

    摘要翻译： 用于确定移动无线电终端是否在无线电通信网络中的区域之外的方法和系统。 所述方法和系统提供使用由移动无线电终端和/或网络进行的测量和/或使用预测值来生成代表该区域的简档。 然后在随后的测量或值和简档之间进行比较，以确定移动无线电终端是否在区域内或外。 方法和系统适用于任何基于区域的应用，包括差分呼叫计费，安全应用，好友查找器服务，移动游戏和基于位置的服务。