-
1.发明授权Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物公开(公告)号：US07241765B2
公开(公告)日：2007-07-10
申请号：US11436099
申请日：2006-05-17
申请人： Alan J. Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl K. Steenstra , Helen Yin , Robert W. DeSimone , Xiao-shu He
发明人： Alan J. Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl K. Steenstra , Helen Yin , Robert W. DeSimone , Xiao-shu He
IPC分类号： A61K31/495 , C07D295/096 , A61K31/451
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译： 提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。 这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
2.发明授权Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物公开(公告)号：US07081458B2
公开(公告)日：2006-07-25
申请号：US11103246
申请日：2005-04-11
IPC分类号： A61K31/407 , A61K31/4439 , C07D487/04
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译： 提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。 这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
公开(公告)号：US07253168B2
公开(公告)日：2007-08-07
申请号：US11100355
申请日：2005-04-06
申请人： Alan J. Hutchison , Bertrand L. Chenard , James G. Tarrant , Guiying Li , Manuka Ghosh , George P. Luke , John M. Peterson , Wallace C. Pringle , Mary-Margaret E. O'Donnell , Kyungae Lee , Linda M. Gustavson , Dario Doller
发明人： Alan J. Hutchison , Bertrand L. Chenard , James G. Tarrant , Guiying Li , Manuka Ghosh , George P. Luke , John M. Peterson , Wallace C. Pringle , Mary-Margaret E. O'Donnell , Kyungae Lee , Linda M. Gustavson , Dario Doller
IPC分类号： A07D241/36 , A61K31/498 , A61P3/04 , A61P3/10 , C07D239/70 , C07D487/08 , C07D471/14 , A61K31/517 , A61K31/407
CPC分类号： C07D213/74 , C07D213/82 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译： 提供了式I化合物，其中变量如本文所述：这样的化合物可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗各种代谢，进食和性障碍 在人类，驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
4.发明授权Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物公开(公告)号：US06953801B2
公开(公告)日：2005-10-11
申请号：US10152189
申请日：2002-05-21
申请人： Alan Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Yiping Shen , Cheryl Steenstra
发明人： Alan Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Yiping Shen , Cheryl Steenstra
IPC分类号： G01N33/53 , A61K31/352 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/551 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07D209/86 , C07D211/44 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D223/04 , C07D239/47 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/108 , C07D295/18 , C07D311/18 , C07D311/58 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D513/04 , G01N33/566
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译： 提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。 这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
公开(公告)号：US20100297035A1
公开(公告)日：2010-11-25
申请号：US12758116
申请日：2010-04-12
申请人： Wallace C. Pringle , John M. Peterson , Linghong Xie , Ping Ge , Yang Gao , Joseph W. Ochterski , Jiong Lan
发明人： Wallace C. Pringle , John M. Peterson , Linghong Xie , Ping Ge , Yang Gao , Joseph W. Ochterski , Jiong Lan
IPC分类号： A61K31/55 , C07D417/06 , A61K31/497 , C07D403/06 , C07D401/04 , A61K31/454 , A61K31/551 , C07D417/14 , C07D487/04 , A61K31/4985 , A61K9/12 , A61P1/08 , A61P3/04 , A61P25/00 , G01N33/53
CPC分类号： C07D231/14 , C07D233/64 , C07D233/90 , C07D277/28 , C07D277/30 , C07D401/06 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/04 , C07D471/04
摘要： Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
摘要翻译： 提供噻唑酰胺，咪唑酰胺和式的相关类似物：其中变量如本文所述。 这样的化合物可用于在体内或体外调节配体与组胺H3受体的结合，并且特别可用于治疗人，家养伴侣动物和家畜中的各种中枢神经系统（CNS）和其他疾病。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。 提供了治疗这种病症的药物组合物和方法，以及使用这种配体检测组胺H3受体的方法（例如，受体定位研究）。
-
公开(公告)号：US07728009B1
公开(公告)日：2010-06-01
申请号：US11816294
申请日：2006-02-16
申请人： Wallace C. Pringle , John M. Peterson , Linghong Xie , Ping Ge , Yang Gao , Joseph W. Ochterski , Jiong Lan
发明人： Wallace C. Pringle , John M. Peterson , Linghong Xie , Ping Ge , Yang Gao , Joseph W. Ochterski , Jiong Lan
IPC分类号： A61K31/445 , C07D241/36
CPC分类号： C07D231/14 , C07D233/64 , C07D233/90 , C07D277/28 , C07D277/30 , C07D401/06 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/04 , C07D471/04
摘要： Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
摘要翻译： 提供噻唑酰胺，咪唑酰胺和式的相关类似物：其中变量如本文所述。 这样的化合物可用于在体内或体外调节配体与组胺H3受体的结合，并且特别可用于治疗人，家养伴侣动物和家畜中的各种中枢神经系统（CNS）和其他疾病。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。 提供了治疗这种病症的药物组合物和方法，以及使用这种配体检测组胺H3受体的方法（例如，受体定位研究）。
-
7.发明授权公开(公告)号：US07272515B2
公开(公告)日：2007-09-18
申请号：US11081042
申请日：2005-03-15
IPC分类号： G01R31/00
CPC分类号： H02H1/0015 , H02H1/0053 , H02H1/0092
摘要： A digital signal processor implementation of three algorithms used to detect high impedance faults. The algorithms can be wavelet based, higher order statistics based and neural network based. The algorithms are modified to process one second of data instead of ten seconds of data and a double buffered acquisition is connected to the output of the algorithms.
摘要翻译： 一种用于检测高阻抗故障的三种算法的数字信号处理器实现。 算法可以基于小波，基于高阶统计和神经网络。 这些算法被修改为处理数据的一秒而不是十秒的数据，并且双缓冲采集被连接到算法的输出。
-
8.发明授权Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4- substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands 失效某些4-氨基甲基-2-取代的咪唑衍生物和2-氨基甲基-4-取代的咪唑衍生物; 新类型的多巴胺受体亚型特异性配体
公开(公告)号：US6069251A
公开(公告)日：2000-05-30
申请号：US859861
申请日：1997-05-21
IPC分类号： C07D233/54 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/06 , C07D403/04
CPC分类号： C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Disclosed are compounds of the formula: ##STR1## wherein R.sub.1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R.sub.3 and R.sub.4 are organic or inorganic substituents which may together form ring structures; m is zero, one or two; and R.sub.5 and R.sub.6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.
摘要翻译： 公开了下式的化合物：其中R 1表示任选取代的芳基，杂芳基，芳烷基或环烷基; X，Z和Y任选被取代的氮或碳原子; R3和R4是可以一起形成环结构的有机或无机取代基; m为零，一或二; R5和R6是有机或无机取代基; 和其药学上可接受的加成盐，该化合物是脑多巴胺受体亚型或其前药的高选择性部分激动剂或拮抗剂，并且可用于诊断和治疗情感障碍如精神分裂症和抑郁症以及某些运动障碍如帕金森综合征 。
-
9.发明授权Certain substituted benzylamine derivatives a new class of Neuropeptide-Y1 specific ligands 失效某些取代的苄胺衍生物是一类新的神经肽-Y1特异性配体
公开(公告)号：US5985873A
公开(公告)日：1999-11-16
申请号：US897044
申请日：1997-07-18
IPC分类号： C07D295/12 , A61K31/495 , A61K31/496 , A61K31/5375 , A61P3/00 , A61P9/04 , A61P9/12 , A61P43/00 , C07D211/46 , C07D211/58 , C07D211/74 , C07D295/135 , C07D295/14 , C07D295/155 , C07D295/20 , C07D491/10 , C07D491/113 , A61K31/535 , C07D401/12
CPC分类号： C07D295/135 , C07D211/46 , C07D211/74 , C07D295/155 , C07D491/10
摘要： This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X.sub.1, X.sub.2, X.sub.3 represent organic or inorganic substituents, n is 1, 2, or 3, R.sub.1 -R.sub.4 are hydrogen or organic substituents, and B is nitrogen, carbon, sulfur or oxygen, useful in the diagnosis and treatment of feeding disorders such as obesity and bulimia and cardiovascular diseases such as essential hypertension and congestive heart failure due to the binding of these compounds to human Neuropeptide Y1 receptors.
摘要翻译： 本发明包括下式的化合物及其药学上可接受的盐，其中X 1，X 2，X 3表示有机或无机取代基，n为1,2或3，R 1 -R 4为氢或有机取代基，B为氮，碳， 硫或氧，可用于诊断和治疗诸如肥胖症和贪食症的进食障碍以及由于这些化合物与人神经肽Y1受体结合导致的心血管疾病如原发性高血压和充血性心力衰竭。
-
10.发明授权Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues 失效黑色素浓缩激素受体配体：取代的2-（4-苄基 - 哌嗪-1-基甲基） - 和2-（4-苄基 - 二氮杂环庚烷-1-基甲基）-1H-苯并咪唑类似物公开(公告)号：US07160879B2
公开(公告)日：2007-01-09
申请号：US10339499
申请日：2003-01-09
申请人： Robert W. DeSimone , John M. Peterson , Cheryl Steenstra , Yiping Shen , Linda M. Gustavson , Christopher Mach , Alan Hutchison
发明人： Robert W. DeSimone , John M. Peterson , Cheryl Steenstra , Yiping Shen , Linda M. Gustavson , Christopher Mach , Alan Hutchison
IPC分类号： A61P15/00 , A61K31/55 , A61K31/495 , C07D243/08 , C07D401/00
CPC分类号： C07D401/06 , C07D235/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Melanin concentrating hormone receptor ligands (especially substituted 2-(4-benzyl-piperazin-1-ylmethyl)-1H-benzoimidazole analogues), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译： 提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是取代的2-（4-苄基 - 哌嗪-1-基甲基）-1H-苯并咪唑类似物）。 这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.038 秒)
