利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

85 条记录 (耗时 0.058 秒)

    4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors
    2.
    发明授权
    4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors 失效
    吡唑并[1,5-a]吡啶，吡唑并[1,5-c]嘧啶和2H-吲唑化合物的4-氰基，4-氨基和4-氨基甲基衍生物和5-氰基，5-氨基和5- 咪唑并[1,2-a]吡啶的氨基甲基衍生物和咪唑并[1,5-a]吡嗪作为细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号：US07700773B2

    公开(公告)日：2010-04-20

    申请号：US11514548

    申请日：2006-08-31

    申请人： Alan K. Mallams ,  Vincent S. Madison ,  Kamil Paruch

    发明人： Alan K. Mallams ,  Vincent S. Madison ,  Kamil Paruch

    IPC分类号： C07D491/02 ,  C07D498/02

    CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

    摘要： In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridine and imidazo[1,5-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

    摘要翻译： 在其许多实施方案中，本发明提供了一类新的吡唑并[1,5-a]吡啶，吡唑并[1,5-c]嘧啶和2H-吡唑并[4,5-a]吡啶的4-氰基，4-氨基和4-氨基甲基衍生物， 吲唑化合物和咪唑并[1,2-a]吡啶和咪唑并[1,5-a]吡嗪化合物的5-氰基，5-氨基和5-氨基甲基衍生物作为细胞周期蛋白依赖性激酶的抑制剂，制备这些化合物的方法， 含有一种或多种这样的化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

    17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    8.
    发明授权
    17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases 失效
    17β-羟类固醇脱氢酶3型抑制剂用于治疗雄激素依赖性疾病

    公开(公告)号：US07476681B2

    公开(公告)日：2009-01-13

    申请号：US11362217

    申请日：2006-02-24

    申请人： Kamil Paruch ,  Timothy J. Guzi

    发明人： Kamil Paruch ,  Timothy J. Guzi

    IPC分类号： A61K31/4545 ,  C07D401/12 ,  C07D401/14

    CPC分类号： C07D211/46 ,  C07D211/58

    摘要： In its many embodiments, the present invention provides a novel class of compounds as illustrated below, wherein the various moieties are described herein, as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, pharmaceutical compositions containing one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17β-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.

    摘要翻译： 在其许多实施方案中，本发明提供了如下所示的新一类化合物，其中各种部分在本文中描述为317β-羟基类固醇脱氢酶的抑制剂，含有一种或多种这样的化合物的药物组合物，以及治疗方法， 使用这些化合物或药物组合物预防，抑制或改善与3型17β-羟类固醇脱氢酶相关的一种或多种疾病。

    Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    9.
    发明申请
    Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors 有权
    新型吡唑并嘧啶作为细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号：US20070281951A1

    公开(公告)日：2007-12-06

    申请号：US11788856

    申请日：2007-04-20

    申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Marc Labroli ,  Kartik Keertikar

    发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Marc Labroli ,  Kartik Keertikar

    IPC分类号： A61K31/495

    CPC分类号： A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or compositions.

    摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的组合物，制备药物制剂的方法，包括 一种或多种这样的化合物，以及使用这些化合物或组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。