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公开(公告)号：US06676988B2
公开(公告)日：2004-01-13
申请号：US10014606
申请日：2001-12-14
IPC分类号： A61L2700
CPC分类号： A61K51/12 , A61K51/1282 , A61N5/1002 , A61N2005/1019
摘要： This invention relates to radioactively coated devices, preferably radioctively coated medical devices. These coated devices are characterized as having a low rate of leaching of the radioisotope from the surface of the coated device and a uniform radioactive coating, and are therefore suitable for use within biological systems. Methods for coating a device with a radioisotope comprising are also disclosed. One method comprises immersing the device within a solution containing a &ggr;, &bgr;+, &agr;, &bgr;− or &egr; (electron capture) emitting radioisotope, then exposing the immersed substrate to tuned vibrational cavitation to produce a coated substrate. A second method involves coating a substrate using electroless plating, and yet a third method involves the use of electroplating a radioisotope onto a substate of interest. With these methods, the coating procedures are followed by baking the coated substrate at a temperature below the recrystallization temperature of the substrate. Substrates coated using the methods of this invention exhibit very low rates of leaching of the coated radioisotope, and are suitable for use within medical applications, for example as stents, catheters, seeds, protheses, vavles, staples and other wound closure devices, where a localized therapeutic treatment is desired.
摘要翻译： 本发明涉及放射性涂覆的装置，优选放射性涂覆的医疗装置。 这些涂覆装置的特征在于放射性同位素从涂覆装置的表面浸出的速度低，并且具有均匀的放射性涂层，因此适用于生物系统。 还公开了包含放射性同位素的装置的涂覆方法。 一种方法包括将装置浸入含有γ，β，α，β或ε（电子捕获）发射放射性同位素的溶液中，然后将浸没的基底暴露于调谐的振动空化以产生涂覆的基底。 第二种方法包括使用无电镀来涂覆基底，然而第三种方法涉及将放射性同位素电镀到感兴趣的基底上。 利用这些方法，涂覆过程之后，在低于基材的再结晶温度的温度下烘烤涂覆的基材。 使用本发明的方法涂覆的底物显示出非常低的涂覆放射性同位素浸出率，并且适用于医疗应用中，例如作为支架，导管，种子，补片，气泡，缝钉和其它伤口闭合装置，其中 需要局部治疗。
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公开(公告)号：US06793798B2
公开(公告)日：2004-09-21
申请号：US10084471
申请日：2002-02-28
IPC分类号： C25D900
CPC分类号： A61K51/12 , A61K51/1282 , A61N5/1002 , A61N2005/1019
摘要： This invention relates to radioactively coated devices, preferably radioactively coated medical devices. These coated devices are characterized as having a low rate of leaching of the radioisotope from the surface of the coated device and a uniform radioactive coating, and are therefore suitable for use within biological systems. Methods for coating a device with a radioisotope comprising are also disclosed. One method comprises immersing the device within a solution containing a &Ugr;, &bgr;+, &agr;, &bgr;− or &egr; (electron capture) emitting radioisotope, then exposing the immersed substrate to tuned vibrational cavitation to produce a coated substrate. A second method involves coating a substrate using electroless plating, and yet a third method involves the use of electroplating a radioisotope onto a substrate of interest. With these methods, the coating procedures are followed by baking the coated substrate at a temperature below the recrystallization temperature of the substrate. Substrates coated using the methods of this invention exhibit very low rates of leaching of the coated radioisotope, and are suitable for use within medical applications, for example as stents, catheters, seeds, protheses, vavles, staples and other wound closure devices, where a localized therapeutic treatment is desired.
摘要翻译： 本发明涉及放射性涂覆的装置，优选放射性涂覆的医疗装置。 这些涂覆装置的特征在于放射性同位素从涂覆装置的表面浸出的速度低，并且具有均匀的放射性涂层，因此适用于生物系统。 还公开了包含放射性同位素的装置的涂覆方法。 一种方法包括将装置浸入含有Upsilon，β+，α，β - 或ε（电子捕获）发射放射性同位素的溶液中，然后将浸没的基材暴露于调谐的振动空化以产生涂覆的基底。 第二种方法包括使用无电电镀来涂覆基底，而第三种方法涉及将放射性同位素电镀到感兴趣的底物上。 利用这些方法，涂覆过程之后，在低于基材的再结晶温度的温度下烘烤涂覆的基材。 使用本发明的方法涂覆的底物显示出非常低的涂覆放射性同位素浸出率，并且适用于医疗应用中，例如作为支架，导管，种子，补片，气泡，缝钉和其它伤口闭合装置，其中 需要局部治疗。
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公开(公告)号：US6103295A
公开(公告)日：2000-08-15
申请号：US995524
申请日：1997-12-22
IPC分类号： A61F2/82 , A61K51/12 , A61L31/00 , A61M36/12 , A61N5/10 , A61M36/14 , A61M36/00 , B05D1/18 , B05D3/02
CPC分类号： A61K51/1282 , A61K51/12 , A61N5/1002
摘要： A method for coating a substrate with a radioisotope comprising is disclosed. The method comprises immersing the substrate within a solution containing a .gamma., .beta..sup.+, .alpha. or .beta..sup.- emitting radioisotope, then exposing the immersed substrate to tuned vibrational cavitation (i.e. ultrasonic) to produce a coated substrate, followed by baking the coated substrate at a temperature below the recrystallization temperature of the substrate. Following this step, the substrate is rinsed and dried. Substrates coated using the method of this invention exhibit very low rates of leaching of the coated radioisotope, and are suitable for use within medical applications.
摘要翻译： 公开了一种用放射性同位素涂覆衬底的方法。 该方法包括将衬底浸入含有γ，β+，α或β发射放射性同位素的溶液中，然后将浸没的基底暴露于调谐的振动空化（即超声波）以产生涂覆的基底，然后在 温度低于衬底的再结晶温度。 在该步骤之后，将基底冲洗并干燥。 使用本发明方法涂覆的底物表现出非常低的涂覆放射性同位素浸出率，并且适用于医疗应用。
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公开(公告)号：US06394945B1
公开(公告)日：2002-05-28
申请号：US09559538
申请日：2000-04-28
IPC分类号： A61N500
CPC分类号： A61K51/12 , A61K51/1282 , A61N5/1002 , A61N2005/1019
摘要： This invention relates to radioactively coated devices, preferably radioactively coated medical devices. These coated devices are characterized as having a low rate of leaching of the radioisotope from the surface of the coated device and a uniform radioactive coating, and are therefore suitable for use within biological systems. Coated medical devices are disclosed that are produced either by immersing the device within a solution containing a &ggr;, &bgr;+, &agr;, &bgr;−, &Egr; (electron capture) emitting radioisotope, then exposing the immersed substrate to tuned vibrational cavitation, by electroless plating, or by electroplating a radioisotope onto a substrate of interest. The medical devices so produced are then baked at a temperature below the recrystallization temperature of the medical device. Medical devices as described herein exhibit very low rates of leaching of the coated radioisotope, and are suitable for use within medical applications, for example as stents, catheters, seeds, protheses, vavles, staples and other wound closure devices, where a localized therapeutic treatment is desired.
摘要翻译： 本发明涉及放射性涂覆的装置，优选放射性涂覆的医疗装置。 这些涂覆装置的特征在于放射性同位素从涂覆装置的表面浸出的速度低，并且具有均匀的放射性涂层，因此适用于生物系统。 公开了涂覆的医疗装置，其通过将装置浸入含有γ，β+，α，β - 和Egr的溶液中而制备; （电子捕获），然后通过无电镀或通过将放射性同位素电镀到感兴趣的衬底上而使浸没的衬底暴露于调谐的振动空化。 然后将如此生产的医疗装置在低于医疗装置的再结晶温度的温度下烘烤。 如本文所述的医疗装置表现出非常低的涂覆放射性同位素浸出率，并且适用于医疗应用中，例如作为支架，导管，种子，补片，气泡，缝钉和其它伤口闭合装置，其中局部治疗处理 是希望的。
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公开(公告)号：US06255847B1
公开(公告)日：2001-07-03
申请号：US09083205
申请日：1998-05-21
申请人： Albert Chan , Ju Shen , Cyrus Y. Tsui , Rafael C. Camarota
发明人： Albert Chan , Ju Shen , Cyrus Y. Tsui , Rafael C. Camarota
IPC分类号： H03K19177
CPC分类号： H03K19/17728 , H03K17/163
摘要： An improved programmable logic device includes a set of I/O cells, a set of logic blocks, and a routing pool that provides connections among the logic blocks and the I/O cells. At least one of the logic blocks includes a programmable logic array that generates product term output signals on product term output lines. A first product term summing circuit has input terminals, at least one of which is coupled to a product term output line. The first product term summing circuit generates an output signal at an output terminal in response to at least one product term output signal. Likewise, a second product term summing circuit has input terminals, at least one of which is coupled to a product term output line. The second product term summing circuit generates an output signal at an output terminal in response to at least one product term output signal. The logic block further includes first and second output lines and a first programmable switching device that programmably couples the first output line to the output terminal of either the first or the second product term summing circuit. The logic block further includes a second programmable switching device that programmably couples the second output line to the output terminal of either the first or the second product term summing circuit. The programmable logic device has increased functional capacity. In addition, generating an interconnect solution to program the programmable logic device is made simpler by the present invention.
摘要翻译： 改进的可编程逻辑器件包括一组I / O单元，一组逻辑块和提供逻辑块和I / O单元之间的连接的路由池。 至少一个逻辑块包括在产品项输出线上产生产品项输出信号的可编程逻辑阵列。 第一乘积项求和电路具有输入端子，其中至少一个耦合到产品项输出线。 第一乘积项求和电路响应于至少一个乘积项输出信号在输出端产生输出信号。 类似地，第二乘积项求和电路具有输入端子，其中至少一个耦合到产品项输出线。 第二乘积项求和电路响应于至少一个乘积项输出信号在输出端产生输出信号。 逻辑块还包括第一和第二输出线以及可编程地将第一输出线耦合到第一或第二乘积项求和电路的输出端的第一可编程开关装置。 逻辑块还包括可编程地将第二输出线耦合到第一或第二乘积项求和电路的输出端的第二可编程开关装置。 可编程逻辑器件具有增加的功能容量。 此外，通过本发明使得生成用于编程可编程逻辑器件的互连解决方案变得更简单。
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公开(公告)号：US6066977A
公开(公告)日：2000-05-23
申请号：US83336
申请日：1998-05-21
申请人： Bradley Felton , Albert Chan , Ju Shen , Cyrus Y. Tsui , Rafael C. Camarota
发明人： Bradley Felton , Albert Chan , Ju Shen , Cyrus Y. Tsui , Rafael C. Camarota
IPC分类号： H03K19/0185 , H03K17/16
CPC分类号： H03K19/018585
摘要： A circuit for providing programmable voltage output levels in a logic device includes a pull-up device for driving an output pad with either a first voltage output level or a second voltage output level. A charge pump generates a pumped voltage. A first clamp regulator, coupled to the charge pump and the pull-up device, receives a first reference signal. The first clamp regulator, in response to the first reference signal, generates a first voltage from which the first voltage output level is derived. A second clamp regulator, coupled to the pull-up device, receives a second reference signal. In response to the second reference signal, the second clamp regulator generates a second voltage from which the second voltage output level is derived. A passgate multiplexer is coupled to the first and second clamp regulators. The passgate multiplexer receives at least one output voltage select signal. In response to the at least one output voltage select signal the passgate multiplexer selects either the first voltage output level or the second voltage output level.
摘要翻译： 用于在逻辑器件中提供可编程电压输出电平的电路包括用于以第一电压输出电平或第二电压输出电平驱动输出焊盘的上拉器件。 电荷泵产生泵浦电压。 耦合到电荷泵和上拉装置的第一钳位调节器接收第一参考信号。 第一钳位调节器响应于第一参考信号产生第一电压，从该第一电压导出第一电压输出电平。 耦合到上拉装置的第二钳位调节器接收第二参考信号。 响应于第二参考信号，第二钳位调节器产生从其导出第二电压输出电平的第二电压。 通道多路复用器耦合到第一和第二钳位调节器。 所述通道门多路复用器接收至少一个输出电压选择信号。 响应于至少一个输出电压选择信号，通道门复用器选择第一电压输出电平或第二电压输出电平。
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公开(公告)号：US20060137879A1
公开(公告)日：2006-06-29
申请号：US11025883
申请日：2004-12-28
申请人： Albert Chan
发明人： Albert Chan
CPC分类号： C09K8/52
摘要： A composition and method for removing a filter cake from a horizontal wellbore in a subterranean formation using a composition containing a inorganic or organic acidic material, a cationic fluorocarbon surfactant, an alkyl alcohol, water optionally containing ammonium chloride and at least one of an alkyl polyglycoside and a betaine surfactant to produce a stable foam used to remove filter cake from a horizontal wellbore.
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公开(公告)号：US20050014633A1
公开(公告)日：2005-01-20
申请号：US10888820
申请日：2004-07-09
申请人： Albert Chan , Liqin Qiu
发明人： Albert Chan , Liqin Qiu
CPC分类号： C07F15/008 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/0266 , B01J2531/80 , C07F9/65527 , C07F15/0053
摘要： The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R′ is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.
摘要翻译： 本发明提供下式的化合物其中R是任选取代的低级烷基，环烷基或芳基; R'是烷基或芳基; n为0或1或2的整数; 或其对映体; 或其对映体混合物。 式（I）化合物是桥连的C2对称联苯二膦类似物，因此可用作配体以产生可用于各种不对称反应的手性过渡金属催化剂。 根据本文公开的方法，本发明的化合物可以以高非对映异构体和光学纯度容易地获得。
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9.发明授权公开(公告)号：US06229336B1
公开(公告)日：2001-05-08
申请号：US09186917
申请日：1998-11-06
申请人： Bradley Felton , Albert Chan , Ju Shen , Cyrus Y. Tsui , Rafael C. Camarota
发明人： Bradley Felton , Albert Chan , Ju Shen , Cyrus Y. Tsui , Rafael C. Camarota
IPC分类号： H03K19173
CPC分类号： H03K17/163 , H03K19/17744 , H03K19/17792
摘要： A programmable integrated circuit device includes a plurality of output terminals, each output terminal for use in transmitting a respective output signal. Timing control circuitry is connected to the output terminals. The timing control circuitry is operable to delay the output signal on each output terminal and is further operable to control a slew rate of the output signal on each output terminal.
摘要翻译： 可编程集成电路装置包括多个输出端子，每个输出端子用于发送相应的输出信号。 定时控制电路连接到输出端子。 定时控制电路可操作以延迟每个输出端上的输出信号，并且还可操作以控制每个输出端上的输出信号的转换速率。
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公开(公告)号：US06191609B1
公开(公告)日：2001-02-20
申请号：US09433642
申请日：1999-11-03
申请人： Albert Chan , Ju Shen , Cyrus Y. Tsui , Allan T. Davidson
发明人： Albert Chan , Ju Shen , Cyrus Y. Tsui , Allan T. Davidson
IPC分类号： H03K19177
CPC分类号： H03K19/1774 , G06F1/10
摘要： A programmable logic device includes a global clock structure and a plurality of localized clock structures. Each localized clock structure distributes a respective localized clock signal to a corresponding portion of the programmable logic device. The global clock structure distributes a global clock signal to all portion of the programmable logic device.
摘要翻译： 可编程逻辑器件包括全局时钟结构和多个局部时钟结构。 每个局部时钟结构将相应的局部时钟信号分配给可编程逻辑器件的对应部分。 全局时钟结构将全局时钟信号分配给可编程逻辑器件的所有部分。
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