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    Implantable or insertable medical device resistant to microbial growth and biofilm formation
    6.
    发明授权
    Implantable or insertable medical device resistant to microbial growth and biofilm formation 有权
    可植入或可插入的医疗器械抗微生物生长和生物膜形成

    公开(公告)号：US09034346B2

    公开(公告)日：2015-05-19

    申请号：US13357033

    申请日：2012-01-24

    申请人： Kathleen M. Miller ,  Gregory T. Sydney ,  Kurt Geitz ,  Peter L. Dayton ,  Ronald A. Sahatjian

    发明人： Kathleen M. Miller ,  Gregory T. Sydney ,  Kurt Geitz ,  Peter L. Dayton ,  Ronald A. Sahatjian

    IPC分类号： A61L2/232 ,  A61L29/16 ,  A61L31/16

    CPC分类号： A61L2/232 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/21 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1372 ,  Y10T428/1379 ,  Y10T428/1386 ,  Y10T428/1393

    摘要： Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

    摘要翻译： 公开了可植入或可插入的医疗装置，其在装置的环境和环境中提供对微生物生长的抵抗力，并且抵抗微生物附着和在装置上的生物膜形成。 特别地，本发明公开了可植入或可插入的医疗装置，其包括至少一个生物相容性基质聚合物区域，用于提供对微生物生长的抗性的抗微生物剂和用于抑制微生物附着的微生物粘附/生物膜合成抑制剂以及合成和积累 生物膜在医疗器械的表面上。 还公开了在基本上防止任何所述生物活性剂优先分配到生物相容性基质聚合物的表面并基本上防止所述生物活性剂的化学修饰的条件下制造这种装置的方法。

    Bodily sample collection balloon catheter
    8.
    发明授权
    Bodily sample collection balloon catheter 失效
    身体样本采集球囊导管

    公开(公告)号：US5919145A

    公开(公告)日：1999-07-06

    申请号：US787303

    申请日：1997-01-24

    申请人： Ronald A. Sahatjian

    发明人： Ronald A. Sahatjian

    IPC分类号： A61B10/00 ,  A61B10/04 ,  A61M29/02

    CPC分类号： A61B10/04 ,  A61M2025/109 ,  A61M25/104

    摘要： Treating a patient by collecting a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a polymer on its outer surface capable of receiving a substantial amount of bodily sample. The catheter is positioned within the body and the sample is taken by exposing the polymer by placing it in proximity within a desired location so that the bodily sample is received by the polymer. The catheter is removed from the patient and the sample is collected outside the body.

    摘要翻译： 通过从患者体内的深处收集身体样品并将样品收集在身体外部以便于治疗患者来治疗患者。 以细长导管的形式提供采样探针，其具有保留在身体外侧的近端部分和可位于体内的远侧部分。 远侧部分在其外表面上包括能够接收大量身体样品的聚合物。 导管定位在体内，并且通过将聚合物放置在所需位置附近而使聚合物暴露而使样品被采集，使得身体样品被聚合物接收。 从患者身上取出导管，将样品收集在体外。

    Medical device balloons containing thermoplastic elastomers
    9.
    发明授权
    Medical device balloons containing thermoplastic elastomers 失效

    公开(公告)号：US5797877A

    公开(公告)日：1998-08-25

    申请号：US653117

    申请日：1996-05-24

    申请人： Bruce Hamilton ,  Ronald A. Sahatjian

    发明人： Bruce Hamilton ,  Ronald A. Sahatjian

    IPC分类号： A61F2/958 ,  A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  A61M29/00

    CPC分类号： A61M25/1029 ,  A61L29/049 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/1075 ,  A61M25/1038

    摘要： A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.

    Sample collection
    10.
    发明授权
    Sample collection 失效
    样品收集

    公开(公告)号：US5533516A

    公开(公告)日：1996-07-09

    申请号：US392101

    申请日：1995-02-22

    申请人： Ronald A. Sahatjian

    发明人： Ronald A. Sahatjian

    IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B10/04 ,  A61B17/00 ,  A61B17/22 ,  A61F2/958

    CPC分类号： A61B10/0275 ,  A61B10/04 ,  A61B17/320725 ,  A61B2017/00292 ,  A61B2017/22001 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2025/109 ,  A61M25/10

    摘要： Taking a bodily sample, e.g., a cell sample, from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a membrane with openings that communicate with space that communicates with a source of suction force. The catheter is positioned within the body. The sample is taken by exposing the membrane by placing it in proximity with a desired location so that the bodily sample is received by the membrane. The catheter is removed from the patient, the sample is collected outside the body, treated, disposed onto a device, such as a graft, stent, or catheter, and reintroduced into the body at a desired site.

    摘要翻译： 从患者体内的深处取出身体样品，例如细胞样品，并将样品收集在身体外部，以便于患者的治疗。 以细长导管的形式提供采样探针，其具有保留在身体外侧的近端部分和可位于体内的远侧部分。 远端部分包括具有开口的膜，所述开口与空气连通，其与吸力源连通。 导管位于体内。 通过将膜放置在所需位置附近，使膜暴露于样品，使得身体样品被膜接收。 将导管从患者身上取出，将样品收集在身体外部，进行处理，置于诸如移植物，支架或导管的装置上，并在期望的位置重新引入体内。