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1.发明申请Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries 审中-公开使用诱导多能细胞和其他细胞筛选化合物库公开(公告)号：US20110237535A1
公开(公告)日：2011-09-29
申请号：US13073233
申请日：2011-03-28
申请人： Alexander Yuzhakov , Eric Sandberg , Steven Shamah , Rick Wagner
发明人： Alexander Yuzhakov , Eric Sandberg , Steven Shamah , Rick Wagner
IPC分类号： A61K31/704 , C12Q1/02 , C12Q1/68 , A61K31/138 , A61K31/4412 , A61K31/135
CPC分类号： G01N33/5014 , G01N33/5058 , G01N33/5061 , G01N33/5088 , G01N2800/32
摘要： The invention provides methods for screening test compounds or toxins for effects on cells. The invention also provides methods for determining frequency, amplitude and kinetic profiles of cells.
摘要翻译： 本发明提供了筛选测试化合物或毒素对细胞效果的方法。 本发明还提供了确定细胞的频率，幅度和动力学特征的方法。
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公开(公告)号：US20100291575A1
公开(公告)日：2010-11-18
申请号：US12781513
申请日：2010-05-17
申请人： Steven Shamah , Lance G. Laing , Alexander Yuzhakov , Rick Wagner , Marla Abodeely , Bennett Rockney , Stephen C. Schulz , Zinkal Padalia , Michael Getman , Eric Sandberg
发明人： Steven Shamah , Lance G. Laing , Alexander Yuzhakov , Rick Wagner , Marla Abodeely , Bennett Rockney , Stephen C. Schulz , Zinkal Padalia , Michael Getman , Eric Sandberg
IPC分类号： C12Q1/68 , G01N33/567 , C12Q1/02
CPC分类号： G01N33/54373 , G01N21/7743 , G01N33/5044 , G01N33/5064 , G01N33/5073
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译： 本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。
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3.发明申请公开(公告)号：US20120058507A1
公开(公告)日：2012-03-08
申请号：US13281089
申请日：2011-10-25
申请人： Steven Shamah , Alexander Yuzhakov , Richard Wagner , Marla Abodeely , Bennett Rockney , Stephen C. Schulz , Zinkal Padalia , Michael Getman
发明人： Steven Shamah , Alexander Yuzhakov , Richard Wagner , Marla Abodeely , Bennett Rockney , Stephen C. Schulz , Zinkal Padalia , Michael Getman
CPC分类号： G01N33/5073 , G01N21/774 , G01N33/5005 , G01N33/5008 , G01N33/54373
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译： 本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。
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公开(公告)号：US20120107840A1
公开(公告)日：2012-05-03
申请号：US13291741
申请日：2011-11-08
IPC分类号： G01N21/84
CPC分类号： G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/5052 , G01N33/53 , G01N33/54373 , G01N33/574 , G01N33/6854 , G01N33/86 , G01N2500/00
摘要： The invention provides methods of detecting activation of an immune cell, methods for detecting blocking or enhancing properties of a test reagent or stimuli on activation of one or more immune cells or platelets, methods for selecting hybridomas producing antibodies to an antigen for quality of strength of binding to the antigen, methods for determining if a subject has had an immune response to an immunogen, methods of isolating neutralizing antibodies for an immunogen, methods of classifying a B cell lymphoma, and methods for selecting activated B-cells expressing an antibody to one or more antigens.
摘要翻译： 本发明提供了检测免疫细胞活化的方法，用于检测在一种或多种免疫细胞或血小板激活时检测试剂或刺激物质的阻断或增强的方法的方法，用于选择产生针对抗原的抗体的杂交瘤的方法， 与抗原结合的方法，用于确定受试者是否具有对免疫原的免疫应答的方法，分离免疫原的中和抗体的方法，B细胞淋巴瘤分类方法和选择表达抗体的活化的B细胞的方法 或更多的抗原。
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5.发明授权公开(公告)号：US09134307B2
公开(公告)日：2015-09-15
申请号：US12335433
申请日：2008-12-15
IPC分类号： C12Q1/04 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6872 , C12Q1/04 , G01N21/78 , G01N33/54373
摘要： The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
摘要翻译： 本发明提供用于鉴定离子通道调节剂的方法，而不使用过表达离子通道蛋白的重组细胞系或检测标记的使用。
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6.发明申请HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA 审中-公开肝细胞生长因子途径激活剂在细胞凋亡和中枢神经系统TRAUMA公开(公告)号：US20110230407A1
公开(公告)日：2011-09-22
申请号：US13118317
申请日：2011-05-27
申请人： Alexander Yuzhakov
发明人： Alexander Yuzhakov
IPC分类号： A61K38/22 , A61K31/415 , A61K48/00 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/42 , A61K31/4704 , A61P25/00
CPC分类号： A61K31/5377 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/4439 , A61K31/454 , A61K31/4704 , A61K38/1833
摘要： Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord injury, by administering a compound or pharmaceutical composition of the invention. Useful compounds include hepatocyte growth factor/scatter factor protein, fragments, fusion polypeptides and muteins thereof, and nucleic acid and expression vectors encoding such proteins. Other useful compounds include small molecule HGF/SF agonists and mimetics.
摘要翻译： 提供了通过施用本发明的化合物或药物组合物来治疗和预防包括多发性硬化的脱髓鞘疾病和包括脑外伤和脊髓损伤在内的中枢神经系统的创伤性损伤的方法。 有用的化合物包括肝细胞生长因子/分散因子蛋白，片段，融合多肽和突变蛋白，以及编码这种蛋白质的核酸和表达载体。 其他有用的化合物包括小分子HGF / SF激动剂和模拟物。
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7.发明申请Bacillus stearothermophilus tau, delta, and delta prime polymerase subunits and use thereof 审中-公开嗜热脂肪芽孢杆菌tau，δ和δ初始聚合酶亚基及其用途公开(公告)号：US20050112580A1
公开(公告)日：2005-05-26
申请号：US10671859
申请日：2003-09-26
申请人： Michael O'Donnell , Alexander Yuzhakov , Olga Yurieva , David Jeruzalmi , Irina Bruck , John Kuriyan
发明人： Michael O'Donnell , Alexander Yuzhakov , Olga Yurieva , David Jeruzalmi , Irina Bruck , John Kuriyan
CPC分类号： C12N9/1252 , C07H21/04 , C12Q1/689
摘要： The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
摘要翻译： 本发明涉及编码DNA聚合酶III型酶亚基的嗜热细菌的分离的DNA分子。 本发明还包括宿主细胞和包括本发明的异源DNA分子的表达系统，以及由这种DNA分子编码的分离的复制酶亚基。 还公开了从嗜热细菌生产重组热稳定DNA聚合酶III型酶或其亚单位的方法，该方法是通过使用本发明的至少一种异源DNA分子转化宿主细胞，在适于 DNA聚合酶III型酶或其亚基的表达，然后分离DNA聚合酶III型酶或其亚单位。
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8.发明申请Nucleic acid encoding Bacillus stearothermophilus delta prime polymerase subunit 审中-公开编码嗜热脂肪芽孢杆菌δ核酸聚合酶亚基的核酸公开(公告)号：US20050153299A1
公开(公告)日：2005-07-14
申请号：US10671106
申请日：2003-09-25
申请人： Michael O'Donnell , Alexander Yuzhakov , Olga Yurieva , David Jeruzalmi , Irina Bruck , John Kuriyan
发明人： Michael O'Donnell , Alexander Yuzhakov , Olga Yurieva , David Jeruzalmi , Irina Bruck , John Kuriyan
CPC分类号： C12N9/1252 , C07H21/04 , C12Q1/689
摘要： The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
摘要翻译： 本发明涉及编码DNA聚合酶III型酶亚基的嗜热细菌的分离的DNA分子。 本发明还包括宿主细胞和包括本发明的异源DNA分子的表达系统，以及由这种DNA分子编码的分离的复制酶亚基。 还公开了从嗜热细菌生产重组热稳定DNA聚合酶III型酶或其亚单位的方法，该方法是通过使用本发明的至少一种异源DNA分子转化宿主细胞，在适于 DNA聚合酶III型酶或其亚基的表达，然后分离DNA聚合酶III型酶或其亚单位。
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9.发明申请Nucleic acid encoding Bacillus stearothermophilus polc polymerase subunit 审中-公开编码嗜热脂肪芽孢杆菌polc聚合酶亚基的核酸公开(公告)号：US20050100920A1
公开(公告)日：2005-05-12
申请号：US10671412
申请日：2003-09-25
申请人： Michael O'Donnell , Alexander Yuzhakov , Olga Yurieva , David Jeruzalmi , Irina Bruck , John Kuriyan
发明人： Michael O'Donnell , Alexander Yuzhakov , Olga Yurieva , David Jeruzalmi , Irina Bruck , John Kuriyan
CPC分类号： C12N9/1252 , C07H21/04 , C12Q1/689
摘要： The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
摘要翻译： 本发明涉及编码DNA聚合酶III型酶亚基的嗜热细菌的分离的DNA分子。 本发明还包括宿主细胞和包括本发明的异源DNA分子的表达系统，以及由这种DNA分子编码的分离的复制酶亚基。 还公开了从嗜热细菌生产重组热稳定DNA聚合酶III型酶或其亚单位的方法，该方法是通过使用本发明的至少一种异源DNA分子转化宿主细胞，在适于 DNA聚合酶III型酶或其亚基的表达，然后分离DNA聚合酶III型酶或其亚单位。
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公开(公告)号：US20090017108A1
公开(公告)日：2009-01-15
申请号：US12216830
申请日：2008-07-11
申请人： Alexander Yuzhakov
发明人： Alexander Yuzhakov
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/7056 , A61K38/212 , A61K2300/00
摘要： In the present invention compositions and methods are described for treating patients with a hepatitis C viral infection typically using interferon-alpha and/or ribavirin which are incorporated into liposomes, wherein the liposomes typically contain at least one carbohydrate moiety on the surface, such as a mono-, di-, oligo-, or polysaccharide moiety or any combination thereof, for targeting to hepatocytes. Other liposome surface modifications are provided to enhance effectiveness of the compound(s) therein.
摘要翻译： 在本发明中，描述了用于治疗患有丙型肝炎病毒感染的患者的组合物和方法，通常使用掺入到脂质体中的干扰素-α和/或利巴韦林，其中脂质体通常在表面上含有至少一个碳水化合物部分，例如 单糖，二糖，寡糖或多糖部分或其任何组合，用于靶向肝细胞。 提供其它脂质体表面修饰以增强其中化合物的有效性。
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