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    Herpesvirus ribozymes and vectors
    1.
    发明申请
    Herpesvirus ribozymes and vectors 有权
    疱疹病毒核酶和载体

    公开(公告)号：US20060116340A1

    公开(公告)日：2006-06-01

    申请号：US10808042

    申请日：2004-03-24

    申请人： Alfred Lewin ,  David Bloom ,  Gregory Schultz ,  Sonal Tuli ,  Jia Liu

    发明人： Alfred Lewin ,  David Bloom ,  Gregory Schultz ,  Sonal Tuli ,  Jia Liu

    IPC分类号： A61K48/00 ,  C12N5/06 ,  C07H21/02

    CPC分类号： C07K14/005 ,  C12N2510/02 ,  C12N2710/16622

    摘要： Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.

    摘要翻译： 合成针对HSV复制（ICP4，UL20，UL30和UL54）关键组分的锤头核酶，并显示出在体外测定中有效切割编码这些成分的一部分的靶RNA。 建立了稳定表达这些核酶的几种克隆细胞系。 与未转染细胞相比，用抗HSV核酶稳定转染的细胞中HSV介导的斑块形成显着降低。

    Cosmetic composition and method
    2.
    发明授权
    Cosmetic composition and method 有权
    化妆品成分及方法

    公开(公告)号：US06713074B2

    公开(公告)日：2004-03-30

    申请号：US09896566

    申请日：2001-06-29

    申请人： David S. Lerner ,  Gregory Schultz

    发明人： David S. Lerner ,  Gregory Schultz

    IPC分类号： A61K700

    CPC分类号： A61Q19/00 ,  A61K8/492 ,  A61K8/63 ,  A61K8/97 ,  A61K31/404 ,  A61K2800/782 ,  A61Q19/08

    摘要： The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, the composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking.

    摘要翻译： 本发明的化妆品局部制剂旨在减少皮肤皱纹，细纹，改善肤色及其组合。 优选地，局部制剂含有基质金属蛋白酶抑制剂MMPI，并且有利地包括天然雌激素，例如真正的雌激素化合物，例如17-β雌二醇或雌激素样类固醇（例如在草药制剂中发现的各种植物雌激素 ），而不是合成雌激素。 本发明的其它形式的化妆品局部制剂包括合成雌激素和MMP抑制剂的组合。 示例性合成的雌激素包括但不限于乙炔雌二醇和柠檬酸氯霉素。 化妆品局部制剂安全有效地减少皱纹，改善肤色。 本发明的某些组合物可用于使对皮肤的光损伤最小化，而在其它实施方案中，根据本发明的组合物可用于预防或最小化由吸烟引起的对皮肤的不利影响。

    Absorbent substrate with a non-leaching antimicrobial activity and a controlled-release bioactive agent.
    3.
    发明申请
    Absorbent substrate with a non-leaching antimicrobial activity and a controlled-release bioactive agent. 审中-公开
    具有非浸出抗菌活性的吸收性底物和受控释放的生物活性剂。

    公开(公告)号：US20080206293A1

    公开(公告)日：2008-08-28

    申请号：US12036107

    申请日：2008-02-22

    申请人： William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Gregory Schultz ,  Gerald Olderman ,  Gregory Staab

    发明人： William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Gregory Schultz ,  Gerald Olderman ,  Gregory Staab

    IPC分类号： A61K9/00 ,  A61F13/00 ,  A61K31/65 ,  A61K38/18 ,  A01N25/08 ,  A01P1/00 ,  A61P31/04 ,  A61K38/02 ,  A01N25/00 ,  A61K31/165 ,  A61K31/14

    CPC分类号： A61L15/44 ,  A61L15/46

    摘要： This invention relates to antimicrobial wound dressings having a non-leaching antimicrobial activity, releasable antimicrobial and antiprotease agents, and a controlled-release bioactive agent such as doxycycline. The Wound dressing material is absorbent and acts as a substrate for antimicrobial and antiprotease agents as well as bioactive agents. More generally, this invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymeric molecules and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy. Utilization of non-leaching coatings having a plurality of anionic or cationic sites is used according to this invention to bind a plurality of oppositely charged biologically or chemically active compounds, and to release the bound oppositely charged biologically or chemically active compounds from said substrate over a period of time to achieve desired objectives as diverse as improved wound healing to reduction in body odor.

    摘要翻译： 本发明涉及具有非浸出抗微生物活性的抗微生物伤口敷料，可释放的抗微生物剂和抗蛋白酶试剂，以及控释释放生物活性剂如多西环素。 伤口敷料材料是吸收剂并用作抗微生物剂和抗蛋白酶剂以及生物活性剂的底物。 更一般来说，本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。 将涂层施加到诸如纱布式伤口敷料，粉末和其它底物的基底上。 在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。 在多长度聚合物分子上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效能的吸收剂或超吸收剂表面。 根据本发明使用具有多个阴离子或阳离子位点的非浸出涂层的使用以结合多个带相反电荷的生物或化学活性化合物，并通过一个或多个阴离子或化学活性化合物从所述底物上释放结合的带相反电荷的生物或化学活性化合物 一段时间以达到预期的目标，如改善伤口愈合以减少体臭。

    Cosmetic Composition and Method
    4.
    发明申请
    Cosmetic Composition and Method 审中-公开
    化妆品成分及方法

    公开(公告)号：US20060165617A1

    公开(公告)日：2006-07-27

    申请号：US11278461

    申请日：2006-04-03

    申请人： David Lerner ,  Gregory Schultz

    发明人： David Lerner ,  Gregory Schultz

    IPC分类号： A61K8/97 ,  A61K31/56 ,  A61K31/704

    CPC分类号： A61K8/42 ,  A61K8/492 ,  A61K8/4986 ,  A61K8/602 ,  A61K8/63 ,  A61K8/97 ,  A61K31/56 ,  A61K31/567 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/08

    摘要： A cosmetic topical formulation and method are directed toward diminishing skin wrinkling and fine lines and improving skin tone. It contains a matrix metalloproteinase inhibitor, MMPI, e.g. batimastat or marimastat, and a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid (such as various phytoestrogens found in herbal preparations). Exemplary phytoestrogens include triterpenoid glycosides. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, a composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking. The method of the invention involves administering the components such as in a dermal preparation.

    摘要翻译： 化妆品局部制剂和方法旨在减少皮肤皱纹和细纹并改善肤色。 它含有基质金属蛋白酶抑制剂，MMPI， 巴马司他或马拉马斯特，以及天然雌激素，例如真正的雌激素化合物，如17-β雌二醇，或雌激素样类固醇（如草药制剂中发现的各种植物雌激素）。 示例性植物雌激素包括三萜糖苷。 本发明的某些组合物可用于最小化对皮肤的光损伤，而在其它实施方案中，根据本发明的组合物可用于防止或最小化由吸烟引起的对皮肤的不利影响。 本发明的方法涉及给予诸如皮肤制剂中的组分。

    Method for minimizing or avoiding adverse effects of vesicants
    5.
    发明申请
    Method for minimizing or avoiding adverse effects of vesicants 审中-公开
    减少或避免发泡剂不良反应的方法

    公开(公告)号：US20080139512A1

    公开(公告)日：2008-06-12

    申请号：US11343024

    申请日：2006-01-30

    申请人： David S. Lerner ,  Gregory Schultz

    发明人： David S. Lerner ,  Gregory Schultz

    IPC分类号： A61K31/665 ,  A61K31/573 ,  A61K31/405 ,  A61K31/137 ,  A61K31/095

    CPC分类号： A61K31/095 ,  A61K31/137 ,  A61K31/405 ,  A61K31/573 ,  A61K31/665 ,  A61K2300/00

    摘要： The invention pertains to compositions and methods to treat the adverse effects of mustard chemicals and other toxic compounds, such as chemical warfare agents, exposure to which normally induces vesicating type response in mammals. In a rodent eye model at fixed concentrations of such a vesicant, compositions comprising a matrix metalloproteinase inhibitor, MMPI, a significant reduction in morbidity is achieved. with increased concentrations of the compositions of this invention, as compared with vehicle alone. Furthermore, compositions comprising the MMPI and in addition, an anti-inflammatory compound, in a vehicle appropriate to the type of tissue damage to be protected against from vesicant exposure, achieves both reduction in total tissue damage and inflammation, as compared with anti-inflammatory composition alone. Chemicals having more than one property, such as MMPI and AIA properties, are also disclosed.

    摘要翻译： 本发明涉及治疗芥子化学物质和其它有毒化合物（例如化学战剂）的不良反应的组合物和方法，其通常在哺乳动物中诱导发泡型反应。 在固定浓度的这种发泡剂的啮齿动物眼模型中，包含基质金属蛋白酶抑制剂MMPI的组合物达到显着降低发病率。 与本发明的组合物的浓度增加，与单独的载体相比。 此外，与抗炎剂相比，包含MMPI的组合物和除了抗炎化合物之外的组合物适合于防止发生泡沫暴露的组织损伤类型的赋形剂，与抗炎剂相比，减少了总组织损伤和炎症 单独组合 还公开了具有多于一种性质的化学品，例如MMPI和AIA性质。

    IP packet ready PBX expansion circuit for a conventional personal computer with expandable, distributed DSP architecture
    6.
    发明申请
    IP packet ready PBX expansion circuit for a conventional personal computer with expandable, distributed DSP architecture 失效
    用于具有可扩展分布式DSP架构的常规个人计算机的IP数据包就绪PBX扩展电路

    公开(公告)号：US20050030941A1

    公开(公告)日：2005-02-10

    申请号：US10931617

    申请日：2004-09-01

    申请人： Paul Lee ,  Charles Lasswell ,  Gregory Schultz

    发明人： Paul Lee ,  Charles Lasswell ,  Gregory Schultz

    IPC分类号： H04L12/28 ,  H04L12/56 ,  H04M3/42 ,  H04M7/00

    CPC分类号： H04M3/42314 ,  H04M7/006

    摘要： A personal computer includes a PBX control program and one or more switch cards located in expansion board slots. The one or more switch cards are coupled to one or more port expansion units (PEU), which are coupled to telecommunication lines out to the various extension phones at the customer premises. Each PEU contains its own digital signal processor (DSP) so that distributed digital signal processing may be implemented to avoid any bottlenecks. One master PEU is coupled to a switch card by a time division multiplexed (TDMA) bus as well as a packet switched control bus, and all the other PEUs, if any, are coupled to the master PEU by extensions of the TDMA and packet switched buses. The TDMA bus carries PBX real time conversations while the packet switched bus carries control information, voicemail outbound message data packets, and inbound voicemail data packets.

    摘要翻译： 个人计算机包括一个PBX控制程序和位于扩展板插槽中的一个或多个交换机卡。 一个或多个开关卡耦合到一个或多个端口扩展单元（PEU），该端口扩展单元（PEU）在电话线路处连接到客户驻地处的各种分机电话。 每个PEU都包含自己的数字信号处理器（DSP），从而可以实现分布式数字信号处理，以避免任何瓶颈。 一个主PEU通过时分多路复用（TDMA）总线以及分组交换控制总线耦合到交换机卡，并且所有其他PEU（如果有的话）通过TDMA和分组交换的扩展耦合到主PEU 巴士 TDMA总线承载PBX实时会话，而分组交换总线承载控制信息，语音邮件出站消息数据分组和入站语音邮件数据分组。

    Saw handle grip
    10.
    发明申请
    Saw handle grip 审中-公开
    锯手柄

    公开(公告)号：US20050138820A1

    公开(公告)日：2005-06-30

    申请号：US11004008

    申请日：2004-12-03

    申请人： Leslie Gist ,  Eric Helda ,  Steven Levine ,  Gregory Schultz

    发明人： Leslie Gist ,  Eric Helda ,  Steven Levine ,  Gregory Schultz

    IPC分类号： B23D51/01 ,  B25G1/00

    CPC分类号： B23D51/01

    摘要： A saw handle grip cover includes a molded shell configured to conform to an outer body shape of a saw handle. The molded shell is constructed of relatively stiff material. An outer layer, secured thereto to the molded shell, is constructed of a softer material than said molded shell. The molded shell covers at least a grippable portion of the saw handle, and the outer layer is delimited by a circumferential outer edge of the molded shell

    摘要翻译： 锯柄柄盖包括被配置成符合锯柄的外部本体形状的模制壳体。 模制外壳由较硬的材料构成。 固定到模制壳体上的外层由比所述模制壳体更软的材料构成。 模制壳体至少覆盖锯柄的可抓握部分，并且外层由模制壳体的周向外边缘限定