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34 条记录 (耗时 0.025 秒)

    USE OF FOXP2 AS A MARKER FOR ABNORMAL LYMPHOCYTES AND AS A TARGET FOR THERAPY OF DISORDERS ASSOCIATED WITH ABNORMAL LYMPHOCYTES
    1.
    发明申请
    USE OF FOXP2 AS A MARKER FOR ABNORMAL LYMPHOCYTES AND AS A TARGET FOR THERAPY OF DISORDERS ASSOCIATED WITH ABNORMAL LYMPHOCYTES 审中-公开
    使用FOXP2作为异常淋巴细胞的标记，作为与异常淋巴细胞相关的疾病治疗目标

    公开(公告)号：US20110300128A1

    公开(公告)日：2011-12-08

    申请号：US13139028

    申请日：2009-12-16

    申请人： Alison Banham ,  Andrew Campbell ,  Duncan Gascoyne ,  Linden Lyne

    发明人： Alison Banham ,  Andrew Campbell ,  Duncan Gascoyne ,  Linden Lyne

    IPC分类号： A61K39/395 ,  C12N5/16 ,  G01N33/574 ,  A61P7/00 ,  A61K31/713 ,  A61K38/02 ,  C07K16/18 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/566

    CPC分类号： G01N33/57426

    摘要： The present invention is directed to a method for detecting abnormal lymphocytes said method comprising detecting an amount or expression of the FOXP2 gene in lymphocytes in a sample, wherein an increased amount or expression of the FOXP2 gene in said lymphocytes indicates the presence of abnormal lymphocytes. Additionally, the invention concerns a method for detecting or assessing a condition associated with the presence of abnormal lymphocytes. The methods of the invention may also be useful for diagnosing myeloma or MGUS or for determining the prognosis for patients with lymphoma, myeloma or MGUS. The severity of bone disease or bone colonisation of tumours may also be able to be predicted. Further, treatment of conditions associated with the presence of abnormal lymphocytes using an agent which inhibits FOXP2 expression and/or FOXP2 activity is provided. An antibody which binds to the N-terminus of FOXP2 has also been developed.

    摘要翻译： 本发明涉及一种用于检测异常淋巴细胞的方法，所述方法包括检测样品中淋巴细胞中FOXP2基因的量或表达，其中所述淋巴细胞中FOXP2基因的增加量或表达指示异常淋巴细胞的存在。 另外，本发明涉及用于检测或评估与异常淋巴细胞存在相关的病症的方法。 本发明的方法还可用于诊断骨髓瘤或MGUS或用于确定淋巴瘤，骨髓瘤或MGUS患者的预后。 也可以预测肿瘤的骨病或骨定植的严重程度。 此外，提供了使用抑制FOXP2表达和/或FOXP2活性的药物治疗与异常淋巴细胞存在相关的病症。 还开发了结合FOXP2的N末端的抗体。

    MONITORING CURRENT LEVEL AND CURRENT INTO AND OUT OF THE ICC READER POWER CONTACTS TO DETECT A PARASITIC SHIM
    4.
    发明申请
    MONITORING CURRENT LEVEL AND CURRENT INTO AND OUT OF THE ICC READER POWER CONTACTS TO DETECT A PARASITIC SHIM 审中-公开
    监测电流和电流进入和离开ICC读取器电源联系人以检测一个PARASIIC SHIM

    公开(公告)号：US20110253788A1

    公开(公告)日：2011-10-20

    申请号：US13087562

    申请日：2011-04-15

    申请人： Andrew Campbell ,  Brian Docherty ,  James Churchman ,  Kevin Maidment ,  Nick McGarvey

    发明人： Andrew Campbell ,  Brian Docherty ,  James Churchman ,  Kevin Maidment ,  Nick McGarvey

    IPC分类号： G06K7/06

    CPC分类号： G06K7/0013 ,  G06K7/0008 ,  H05K1/0219 ,  H05K1/0275 ,  H05K2201/09263 ,  H05K2201/10204

    摘要： The present invention detects the current flowing through the contacts of the smart card reader due to the presence of a “shim”. Small value resistors are connected in series with either the Power connection or the Ground connection, or both. Values are typically 47 milliohms to 100 milliohms. The use of such small values ensures that little voltage is dropped across the resistors and that the card is therefore adequately powered. With no card present, the current through these resistors should be zero and therefore the voltage across the resistors will also be zero. Amplifier circuits are employed to monitor and amplify the voltage across the resistors and in the “PayPod” design the amplifier outputs are connected to analogue to digital inputs on the microprocessor. Where the microprocessor (or other processing electronics) used has no analogue to digital inputs, separate analogue to digital circuits may be used. The microprocessor may then monitor the current flowing into the power supply contacts of the card reader.

    摘要翻译： 本发明由于存在“垫片”而检测流过智能卡读卡器的触头的电流。 小值电阻器与电源连接或接地连接或两者连接。 值通常为47毫欧至100毫欧。 使用这样小的值确保电阻器上的电压几乎没有下降，因此卡片被充分供电。 没有存在卡，通过这些电阻的电流应为零，因此电阻两端的电压也将为零。 采用放大器电路来监视和放大电阻两端的电压，而在“PayPod”设计中，放大器输出端连接到微处理器上的模拟数字输入端。 在使用微处理器（或其他处理电子设备）没有模数转换器的情况下，可以使用单独的模数转换电路。 然后，微处理器可以监测流入读卡器的电源触点的电流。

    Multiple mode controlling signal processing apparatus
    6.
    发明授权
    Multiple mode controlling signal processing apparatus 失效
    多模控制信号处理装置

    公开(公告)号：US5867225A

    公开(公告)日：1999-02-02

    申请号：US738831

    申请日：1996-10-28

    申请人： Stephen Mark Keating ,  Andrew Campbell ,  Alan Turner

    发明人： Stephen Mark Keating ,  Andrew Campbell ,  Alan Turner

    IPC分类号： G06F17/10 ,  H04N5/202 ,  H04N5/208 ,  H04N5/44 ,  H04N7/01 ,  H04N11/20 ,  H04N5/46 ,  H04N9/64

    CPC分类号： H04N7/0135 ,  G06F17/10 ,  H04N11/20 ,  H04N5/208 ,  H04N7/0125 ,  H04N5/202 ,  H04N7/012

    摘要： Signal processing apparatus comprises a control read only memory storing:(i) two or more sets of signal processing parameter data to control signal processing operations of the apparatus; and(ii) configuration data specifying one of the sets of signal processing parameter data stored in the control read only memory;a control read/write memory capable of storing:(i) at least one set of signal processing parameter data; and(ii) configuration data capable of specifying a set of signal processing parameter data stored in the control read only memory or a set of signal processing parameter data stored in the control read/write memory;and control logic, responsive to an input selection signal specifying whether the configuration data in the control read only memory or the configuration data in the read/write memory should be selected for use, for controlling the signal processing apparatus to perform signal processing operations in accordance with the signal processing parameter data specified by the selected configuration data.

    摘要翻译： 信号处理装置包括控制只读存储器，其存储：（i）两组或多组信号处理参数数据，用于控制装置的信号处理操作; 和（ii）指定存储在控制只读存储器中的信号处理参数数据组之一的配置数据; 控制读/写存储器，其能够存储：（i）至少一组信号处理参数数据; 以及（ii）能够指定存储在控制只读存储器中的一组信号处理参数数据或存储在控制读/写存储器中的一组信号处理参数数据的配置数据; 以及控制逻辑，其响应于指定所述控制只读存储器中的配置数据或所述读/写存储器中的配置数据是否应被选择使用的输入选择信号，以控制所述信号处理设备执行信号处理操作 与所选配置数据指定的信号处理参数数据。

    Sensor device with mounting means
    7.
    发明授权
    Sensor device with mounting means 有权

    公开(公告)号：US10041532B2

    公开(公告)日：2018-08-07

    申请号：US14960524

    申请日：2015-12-07

    申请人： Andrew Campbell ,  Allan Thomson

    发明人： Andrew Campbell ,  Allan Thomson

    IPC分类号： F16C19/52 ,  B61F15/20 ,  B60B27/00 ,  G01D11/02 ,  G01D11/30 ,  G01K1/16 ,  B61L15/00 ,  G01D11/24 ,  G01H1/00 ,  G01H3/00

    摘要： A sensor device for monitoring a component of interest, including at least one sensor for measuring at least one parameter indicative of condition of the component of interest, signal processing device for processing the signals of the sensor, a housing for at least the signal processing device and a mounting feature for mounting the sensor device close to the component of interest. The mounting feature can include a bolt and bracket having a first portion including an opening for inserting the bolt in an insertion direction and a second portion with a surface parallel to the insertion direction configured to mount the housing.

    Assembly and Welding Method for Coupling a Rotor to the Shaft of a Pedal Assembly
    9.
    发明申请
    Assembly and Welding Method for Coupling a Rotor to the Shaft of a Pedal Assembly 审中-公开
    用于将转子耦合到踏板组件的轴的组装和焊接方法

    公开(公告)号：US20110314956A1

    公开(公告)日：2011-12-29

    申请号：US13162213

    申请日：2011-06-16

    申请人： Andrew Campbell ,  Willie Campbell

    发明人： Andrew Campbell ,  Willie Campbell

    IPC分类号： G05G1/44 ,  B32B37/16 ,  G05G1/50 ,  F16B11/00

    CPC分类号： G05G1/50 ,  Y10T74/20888 ,  Y10T403/477

    摘要： An assembly and method for coupling the rotor of a vehicle pedal assembly to the shaft of a vehicle pedal assembly. In one embodiment, the rotor includes a collar with an interior surface defining a plurality of slots and the shaft includes a distal neck which extends into the collar of the rotor. A weld horn is inserted into the collar and into contact with the neck of the shaft for melting a portion of the neck and causing the material of the molten neck to flow into the slots for securing the rotor to the shaft.

    摘要翻译： 一种用于将车辆踏板组件的转子联接到车辆踏板组件的轴的组件和方法。 在一个实施例中，转子包括具有限定多个狭槽的内表面的套环，并且该轴包括延伸到转子的套环中的远端颈部。 将焊接喇叭插入到轴环中并与轴的颈部接触，以熔化颈部的一部分，并使熔融颈部的材料流入狭槽以将转子固定到轴上。

    Accelerator Pedal for a Vehicle and Mounting Rack Therefor
    10.
    发明申请
    Accelerator Pedal for a Vehicle and Mounting Rack Therefor 有权
    用于车辆和安装架的加速踏板

    公开(公告)号：US20110162481A1

    公开(公告)日：2011-07-07

    申请号：US13049271

    申请日：2011-03-16

    申请人： Andrew Campbell

    发明人： Andrew Campbell

    IPC分类号： G05G1/30

    CPC分类号： G05G1/38 ,  B60K26/021 ,  G05G5/03

    摘要： A pedal assembly including a rack for mounting the pedal assembly to the wall of a vehicle. In one embodiment, the rack includes a plate with at least one clip bracket, a locating pin aperture, and a pair of mounting apertures. The plate is coupled to the pedal assembly in a relationship wherein the clip bracket receives a mounting clip formed on the pedal assembly, the locating pin aperture receives a locating pin formed on the pedal assembly, and the mounting apertures in the plate are aligned with respective mounting apertures defined on the pedal assembly and receive fasteners which secure the rack to the pedal.

    摘要翻译： 一种踏板组件，包括用于将踏板组件安装到车辆的墙壁上的齿条。 在一个实施例中，机架包括具有至少一个夹子支架，定位销孔和一对安装孔的板。 该板以一种关系联接到踏板组件，其中夹子支架接收形成在踏板组件上的安装夹，定位销孔容纳形成在踏板组件上的定位销，并且板中的安装孔与相应的 限定在踏板组件上的安装孔，并且接收将架固定到踏板上的紧固件。