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公开(公告)号：US06277597B1
公开(公告)日：2001-08-21
申请号：US09366623
申请日：1999-08-03
申请人： Alison F Chalker , David J Holmes , Karen A Ingraham , Chi Young So , John P Throup , Stephanie Van Horn , Richard L Warren
发明人： Alison F Chalker , David J Holmes , Karen A Ingraham , Chi Young So , John P Throup , Stephanie Van Horn , Richard L Warren
IPC分类号： C12N1509
CPC分类号： C12N9/1241 , A61K38/00 , C12Q1/689 , C12Q2600/158 , C12Y207/07003
摘要： The invention provides kdtB polypeptides and polynucleotides encoding kdtB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing kdtB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供kdtB多肽和编码kdtB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用kdtB多肽筛选抗菌化合物的方法。
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公开(公告)号：US06168797A
公开(公告)日：2001-01-02
申请号：US09376689
申请日：1999-08-18
申请人： Sanjoy Biswas , Martin K R Burnham , Jason C Fedon , David J Holmes , Karen A Ingraham , Howard Kallender , John T Lonsdale , Marie J Mazzulla , Karen M O'Dwyer , Leslie M Palmer , Chi Young So , Christopher M Traini , Glenn S Van Aller , Stephanie Van Horn , Magdalena Zalacain
发明人： Sanjoy Biswas , Martin K R Burnham , Jason C Fedon , David J Holmes , Karen A Ingraham , Howard Kallender , John T Lonsdale , Marie J Mazzulla , Karen M O'Dwyer , Leslie M Palmer , Chi Young So , Christopher M Traini , Glenn S Van Aller , Stephanie Van Horn , Magdalena Zalacain
IPC分类号： A61K3909
CPC分类号： C12N9/1029
摘要： The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了fabF多肽和编码fabF多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用fabF多肽筛选抗菌化合物的方法。
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公开(公告)号：US06204014B1
公开(公告)日：2001-03-20
申请号：US09191879
申请日：1998-11-13
申请人： Alison F Chalker , David J Holmes , Karen A Ingraham , Deborah D Jaworski , Anna L Lenox , Earl W May , Marie J Mazzulla , Jennifer Ray , Min Wang , Richard L Warren, Jr.
发明人： Alison F Chalker , David J Holmes , Karen A Ingraham , Deborah D Jaworski , Anna L Lenox , Earl W May , Marie J Mazzulla , Jennifer Ray , Min Wang , Richard L Warren, Jr.
IPC分类号： C12P2106
CPC分类号： C12N9/90 , A61K38/00 , C07K2319/00
摘要： The invention provides DnaB polypeptides and polynucleotides encoding DnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DnaB polypeptides to screen for anibacterial compounds.
摘要翻译： 本发明提供DnaB多肽和编码DnaB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用DnaB多肽来筛选细菌化合物的方法。
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公开(公告)号：US06326167B1
公开(公告)日：2001-12-04
申请号：US09298724
申请日：1999-04-23
申请人： Alison F Chalker , Sauli J Haataja , David W Holden , David J Holmes , Karen A Ingraham , Gee W Lau , Andrea Marra , Michael A Lonetto , Damien McDevitt , Jennifer Ray , Jun Yu
发明人： Alison F Chalker , Sauli J Haataja , David W Holden , David J Holmes , Karen A Ingraham , Gee W Lau , Andrea Marra , Michael A Lonetto , Damien McDevitt , Jennifer Ray , Jun Yu
IPC分类号： C07H2104
CPC分类号： C07K16/40
摘要： The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.
摘要翻译： 本发明提供tktA多肽和编码tktA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用tktA多肽和多核苷酸筛选抗菌化合物和检测肺炎链球菌的方法。
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公开(公告)号：US6162619A
公开(公告)日：2000-12-19
申请号：US81686
申请日：1998-05-20
申请人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
CPC分类号： C12N9/1205
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US07128920B2
公开(公告)日：2006-10-31
申请号：US10610295
申请日：2003-06-30
IPC分类号： A61K39/09
CPC分类号： C12N9/93 , C07K14/3156 , C12Q1/689
摘要： The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
摘要翻译： 本发明提供了metRS2多肽和编码metRS2多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用metRS2多肽和多核苷酸作为诊断试剂和在诊断测定中筛选生物体中的微生物感染和材料侵染的优选方法。
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公开(公告)号：US07304152B2
公开(公告)日：2007-12-04
申请号：US11424836
申请日：2006-06-16
IPC分类号： C07H21/04
CPC分类号： C12N9/93 , C07K14/3156 , C12Q1/689
摘要： The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
摘要翻译： 本发明提供了metRS2多肽和编码metRS2多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用metRS2多肽和多核苷酸作为诊断试剂和在诊断测定中筛选生物体中的微生物感染和材料感染的优选方法。
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公开(公告)号：US06274719B1
公开(公告)日：2001-08-14
申请号：US09066512
申请日：1998-04-24
申请人： Sanjoy Biswas , Alison Frances Chalker , David Holmes , Karen A Ingraham , Leslie Marie Palmer , Jennifer E Ray , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Alison Frances Chalker , David Holmes , Karen A Ingraham , Leslie Marie Palmer , Jennifer E Ray , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07H2104
CPC分类号： C12N9/80 , A61K38/00 , C07K14/3156 , Y10S530/82 , Y10S530/825
摘要： The invention provides gcp polypeptides and polynucleotides encoding gcp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gcp polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了gcp多肽和编码gcp多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用gcp多肽筛选抗菌化合物的方法。
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公开(公告)号：US06294652B1
公开(公告)日：2001-09-25
申请号：US09487370
申请日：2000-01-18
申请人： Sanjoy Biswas , James Yigong Ge , David John Holmes , Karen A Ingraham , John Throup , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , James Yigong Ge , David John Holmes , Karen A Ingraham , John Throup , Nicola Gail Wallis , Magdalena Zalacain
IPC分类号： C01K100
CPC分类号： C12N9/1223 , C07K14/3156 , Y10T436/105831
摘要： The invention provides Response regulator polypeptides and polynucleotides encoding Response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.
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公开(公告)号：US06225087B1
公开(公告)日：2001-05-01
申请号：US09139064
申请日：1998-08-25
申请人： Sanjoy Biswas , James Yigong Ge , David John Holmes , Karen A Ingraham , John Throup , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , James Yigong Ge , David John Holmes , Karen A Ingraham , John Throup , Nicola Gail Wallis , Magdalena Zalacain
IPC分类号： C12N1500
CPC分类号： C12N9/1223 , C07K14/3156 , Y10T436/105831
摘要： The invention provides Response regulator polypeptides and polynucleotides encoding Response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了响应调节剂多肽和编码响应调节多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用响应调节剂多肽筛选抗菌化合物的方法。
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