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公开(公告)号：US20080021217A1
公开(公告)日：2008-01-24
申请号：US11780735
申请日：2007-07-20
申请人： Allen Borchardt , Mehmet Kahraman , Travis Cook , Robert Davis , Elizabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins , Michael Sertic , Dana Siegel
发明人： Allen Borchardt , Mehmet Kahraman , Travis Cook , Robert Davis , Elizabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins , Michael Sertic , Dana Siegel
IPC分类号： A61K31/44 , A61K31/495 , A61K31/519 , C07D237/26 , C07D401/14 , C07D413/00 , C07D413/14 , C07D417/04 , C07D487/00
CPC分类号： A61K31/395 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
摘要翻译： 本发明涉及可用作Rho激酶抑制剂用于治疗或预防疾病的化合物和方法。
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公开(公告)号：US20080021026A1
公开(公告)日：2008-01-24
申请号：US11780834
申请日：2007-07-20
申请人： Mehmet Kahraman , Allen Borchardt , Travis Cook , Robert Davis , Elisabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins
发明人： Mehmet Kahraman , Allen Borchardt , Travis Cook , Robert Davis , Elisabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins
IPC分类号： A61K31/44 , A61K31/415 , A61K31/497 , A61K31/535
CPC分类号： A61K31/395 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
摘要翻译： 本发明涉及可用作Rho激酶抑制剂用于治疗或预防疾病的化合物和方法。
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3.发明申请Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders 审中-公开p38激酶的新型邻三苯基抑制剂和治疗炎症性疾病的方法公开(公告)号：US20060252807A1
公开(公告)日：2006-11-09
申请号：US11409451
申请日：2006-04-20
申请人： Daniel Severance , Elisabeth Gardiner , Stewart Noble , Boliang Lou , Allen Borchardt , Jeffrey Roppe , Mehmet Kahraman , Dana Siegel , Shawn Scranton
发明人： Daniel Severance , Elisabeth Gardiner , Stewart Noble , Boliang Lou , Allen Borchardt , Jeffrey Roppe , Mehmet Kahraman , Dana Siegel , Shawn Scranton
IPC分类号： C07D417/04 , A61K31/433 , A61K31/426
CPC分类号： C07D413/04 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/426 , A61K31/433 , C07D263/16 , C07D277/56 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases.
摘要翻译： 本发明涉及可用作p38激酶抑制剂的化合物和方法，用于治疗或预防和治疗疾病如炎症性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，血管生成性疾病，感染性疾病，神经变性疾病和病毒性疾病 。
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4.发明申请公开(公告)号：US20110237565A1
公开(公告)日：2011-09-29
申请号：US13044661
申请日：2011-03-10
申请人： Allen Borchardt , Robert Davis , Stewart A. Noble
发明人： Allen Borchardt , Robert Davis , Stewart A. Noble
IPC分类号： A61K31/397 , C07D487/04 , A61K31/496 , C07D413/14 , C07D471/04 , A61K31/4985 , A61P37/08 , A61P27/02 , A61P17/04 , A61P11/00
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及可用作H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。
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公开(公告)号：US20110237599A1
公开(公告)日：2011-09-29
申请号：US13044035
申请日：2011-03-09
申请人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Gamache , Mark Hellberg , Peter Klimko , John Yanni
发明人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Gamache , Mark Hellberg , Peter Klimko , John Yanni
IPC分类号： A61K31/496 , C07D487/04 , A61P35/00 , A61P27/02 , A61P27/12 , A61P11/06 , A61P11/00 , A61P37/08 , A61P17/04
CPC分类号： A61K31/381 , A61K31/519 , C07D495/14
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
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![Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease](/abs-image/US/2013/10/29/US08569300B2/abs.jpg.150x150.jpg)
6.发明授权Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease 有权用于治疗疾病的组胺受体的取代四唑[1,5-A]吡嗪抑制剂公开(公告)号：US08569300B2
公开(公告)日：2013-10-29
申请号：US13044661
申请日：2011-03-10
申请人： Allen Borchardt , Robert Davis , Stewart A. Noble
发明人： Allen Borchardt , Robert Davis , Stewart A. Noble
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04
摘要： The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及用于式IX的取代的四唑[1,5-a]吡嗪化合物及其药物组合物，其可用作H4R的抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病 。
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7.发明申请公开(公告)号：US20110257137A1
公开(公告)日：2011-10-20
申请号：US13044906
申请日：2011-03-10
申请人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Becker , Daniel Gamache , Stewart A. Noble , Mark Hellberg , Peter Klimko , Zhihai Qiu , Joseph Payne , John Yanni
发明人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Becker , Daniel Gamache , Stewart A. Noble , Mark Hellberg , Peter Klimko , Zhihai Qiu , Joseph Payne , John Yanni
IPC分类号： A61K31/56 , C07D498/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K31/5377 , A61K31/496 , A61P29/00 , A61P37/08 , A61P11/06 , A61P27/02 , A61P11/00 , A61P17/00 , A61P17/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。
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8.发明申请INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME 失效HEPATITIS C病毒RNA依赖RNA聚合酶的抑制剂及其组合物和治疗公开(公告)号：US20060189681A1
公开(公告)日：2006-08-24
申请号：US11382154
申请日：2006-05-08
申请人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock
发明人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock
IPC分类号： A61K31/366 , C07D309/30
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上 这里。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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9.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07473790B2
公开(公告)日：2009-01-06
申请号：US11382154
申请日：2006-05-08
IPC分类号： C07D309/30 , C07D305/00 , C07D309/00
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2如本文所定义。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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10.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07148226B2
公开(公告)日：2006-12-12
申请号：US10718337
申请日：2003-11-19
IPC分类号： A61K31/519
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上 这里。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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