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1.发明申请Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders 审中-公开p38激酶的新型邻三苯基抑制剂和治疗炎症性疾病的方法公开(公告)号：US20060252807A1
公开(公告)日：2006-11-09
申请号：US11409451
申请日：2006-04-20
申请人： Daniel Severance , Elisabeth Gardiner , Stewart Noble , Boliang Lou , Allen Borchardt , Jeffrey Roppe , Mehmet Kahraman , Dana Siegel , Shawn Scranton
发明人： Daniel Severance , Elisabeth Gardiner , Stewart Noble , Boliang Lou , Allen Borchardt , Jeffrey Roppe , Mehmet Kahraman , Dana Siegel , Shawn Scranton
IPC分类号： C07D417/04 , A61K31/433 , A61K31/426
CPC分类号： C07D413/04 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/426 , A61K31/433 , C07D263/16 , C07D277/56 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases.
摘要翻译： 本发明涉及可用作p38激酶抑制剂的化合物和方法，用于治疗或预防和治疗疾病如炎症性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，血管生成性疾病，感染性疾病，神经变性疾病和病毒性疾病 。
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公开(公告)号：US20080021026A1
公开(公告)日：2008-01-24
申请号：US11780834
申请日：2007-07-20
申请人： Mehmet Kahraman , Allen Borchardt , Travis Cook , Robert Davis , Elisabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins
发明人： Mehmet Kahraman , Allen Borchardt , Travis Cook , Robert Davis , Elisabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins
IPC分类号： A61K31/44 , A61K31/415 , A61K31/497 , A61K31/535
CPC分类号： A61K31/395 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
摘要翻译： 本发明涉及可用作Rho激酶抑制剂用于治疗或预防疾病的化合物和方法。
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公开(公告)号：US20080021217A1
公开(公告)日：2008-01-24
申请号：US11780735
申请日：2007-07-20
申请人： Allen Borchardt , Mehmet Kahraman , Travis Cook , Robert Davis , Elizabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins , Michael Sertic , Dana Siegel
发明人： Allen Borchardt , Mehmet Kahraman , Travis Cook , Robert Davis , Elizabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins , Michael Sertic , Dana Siegel
IPC分类号： A61K31/44 , A61K31/495 , A61K31/519 , C07D237/26 , C07D401/14 , C07D413/00 , C07D413/14 , C07D417/04 , C07D487/00
CPC分类号： A61K31/395 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
摘要翻译： 本发明涉及可用作Rho激酶抑制剂用于治疗或预防疾病的化合物和方法。
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公开(公告)号：US20060167012A1
公开(公告)日：2006-07-27
申请号：US11258463
申请日：2005-10-25
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
IPC分类号： A61K31/495 , A61K31/4439 , A61K31/44 , C07D403/02
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20060205736A1
公开(公告)日：2006-09-14
申请号：US11435082
申请日：2006-05-16
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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6.发明申请Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease 审中-公开多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病公开(公告)号：US20070027184A1
公开(公告)日：2007-02-01
申请号：US11496784
申请日：2006-07-27
申请人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
发明人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
IPC分类号： A61K31/47 , C07D215/12 , C07D319/14 , A61K31/36
CPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译： 本文公开的是本文所述的式VII的磺酰胺化合物。 公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地中海贫血，炎性病症，心血管疾病 以及使用本发明化合物的血管发生在发病机理中起作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。
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公开(公告)号：US20080027099A1
公开(公告)日：2008-01-31
申请号：US11774053
申请日：2007-07-06
申请人： Steven Govek , Andrew Shiau , Stewart Noble , David Thomas
发明人： Steven Govek , Andrew Shiau , Stewart Noble , David Thomas
IPC分类号： A61K31/4709 , A61P29/00 , C07D401/12
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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8.发明申请Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders 审中-公开芳基磺酰胺和磺酰化合物作为PPAR的调节剂和治疗代谢紊乱的方法公开(公告)号：US20050234046A1
公开(公告)日：2005-10-20
申请号：US11102356
申请日：2005-04-07
申请人： Cunxiang Zhao , James Malecha , Stewart Noble , Sergio Duron , Andrew Lindstrom , Andrew Shiau
发明人： Cunxiang Zhao , James Malecha , Stewart Noble , Sergio Duron , Andrew Lindstrom , Andrew Shiau
IPC分类号： A61K31/407 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/504 , A61K31/506 , A61K31/529 , A61K31/551 , C07D211/96 , C07D213/74 , C07D237/20 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/82 , C07D295/26 , C07D307/46 , C07D307/79 , C07D317/66 , C07D401/04 , C07D417/02 , C07D417/04 , C07D487/08 , C07D43/04
CPC分类号： C07D211/96 , C07D213/74 , C07D237/20 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/82 , C07D295/26 , C07D307/46 , C07D307/79 , C07D317/66 , C07D401/04 , C07D417/04 , C07D487/08
摘要： Aryl sulfonamide and sulfonyl compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的芳基磺酰胺和磺酰化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US09604242B2
公开(公告)日：2017-03-28
申请号：US12095695
申请日：2006-06-23
申请人： Joseph Hess , Amir Feriani , Luciano Cravero , Stewart Noble , Victor Ques
发明人： Joseph Hess , Amir Feriani , Luciano Cravero , Stewart Noble , Victor Ques
CPC分类号： B05B17/0638 , A61L9/01 , A61L9/127 , A61L9/145 , B05B17/0646 , B05B17/0669 , B05B17/0676 , B05B17/0684
摘要： A volatile liquid droplet dispenser for containing a liquid to be dispensed, with a first substrate having a space for containing the liquid, and having an outlet with at least one outlet nozzle, the first substrate further having the space adjacent to the liquid outlet, to receive the liquid such that the liquid may exit through at least one outlet nozzle of the outlet, a second substrate having a liquid inlet, and an actuating membrane arranged to actuate liquid in the space.The first substrate also has a fluidic channel interconnected to the space and arranged to laterally connect the liquid inlet to the space, thereby conveying the liquid to the space by way of lateral capillary action. The outlet is eccentric to the liquid inlet and in a vertical plane that is substantially the same or lower than the plane of the liquid inlet, depending on the liquid used.
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10.发明申请公开(公告)号：US20060258683A1
公开(公告)日：2006-11-16
申请号：US10551930
申请日：2004-04-07
申请人： Kevin Liu , James Malecha , Stewart Noble , Paul Wash
发明人： Kevin Liu , James Malecha , Stewart Noble , Paul Wash
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D213/74 , C07D239/42 , C07D295/26 , C07D307/68
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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