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    Apparatus for retaining magnetic particles within a flow-through cell
    1.
    发明申请
    Apparatus for retaining magnetic particles within a flow-through cell 失效
    用于将磁性颗粒保持在流通池内的装置

    公开(公告)号：US20050208464A1

    公开(公告)日：2005-09-22

    申请号：US10502556

    申请日：2003-01-22

    申请人： Amar Rida ,  Olivier Elsenhans ,  Martin Gijs ,  Goran Savatic

    发明人： Amar Rida ,  Olivier Elsenhans ,  Martin Gijs ,  Goran Savatic

    IPC分类号： G01N33/53 ,  B03C1/035 ,  B03C1/28 ,  G01N33/553 ,  C12Q1/00 ,  C12M1/34

    CPC分类号： B03C1/035 ,  B03C1/288

    摘要： An apparatus for retaining magnetic particles within a segment of a flow-through cell during flow of a fluid through the cell comprises (a) optionally, an electrical current source; (b) an electromagnet having a winding connected to the current source and an air gap between at least one pair of poles each of which has a corrugated outer surface and (c) a flow-through cell which is configured and dimensioned to receive an amount of magnetic particles to be retained within the flow-through cell and to allow flow of a liquid through the flow-through cell. The liquid carries molecules or particles to be captured by means of the magnetic particles. A portion of the flow-through cell is inserted in air gap.

    摘要翻译： 一种用于在流体通过电池的流动期间将磁性颗粒保持在流通池的段内的装置包括（a）可选地，电流源; （b）具有连接到电流源的绕组的电磁体和在至少一对磁极之间的空气间隙，每个磁极具有波纹状的外表面，以及（c）流通电池，其配置和尺寸设置为接收一定量 的磁性颗粒保留在流通池内并允许液体流过流通池。 液体携带通过磁性颗粒捕获的分子或颗粒。 流通池的一部分插入气隙中。

    Apparatus for retaining magnetic particles within a flow-through cell
    2.
    发明授权
    Apparatus for retaining magnetic particles within a flow-through cell 失效
    用于将磁性颗粒保持在流通池内的装置

    公开(公告)号：US07601265B2

    公开(公告)日：2009-10-13

    申请号：US10502556

    申请日：2003-01-22

    申请人： Amar Rida ,  Olivier Elsenhans ,  Martin Gijs ,  Goran Savatic

    发明人： Amar Rida ,  Olivier Elsenhans ,  Martin Gijs ,  Goran Savatic

    IPC分类号： C02F1/48

    CPC分类号： B03C1/035 ,  B03C1/288

    摘要： An apparatus for retaining magnetic particles within a segment of a flow-through cell during flow of a fluid through the cell comprises (a) optionally, an electrical current source; (b) an electromagnet having a winding connected to the current source and an air gap between at least one pair of poles each of which has a corrugated outer surface and (c) a flow-through cell which is configured and dimensioned to receive an amount of magnetic particles to be retained within the flow-through cell and to allow flow of a liquid through the flow-through cell. The liquid carries molecules or particles to be captured by means of the magnetic particles. A portion of the flow-through cell is inserted in air gap.

    摘要翻译： 一种用于在流体通过电池的流动期间将磁性颗粒保持在流通池的段内的装置包括（a）可选地，电流源; （b）具有连接到电流源的绕组的电磁体和在至少一对磁极之间的空气间隙，每个磁极具有波纹状的外表面，以及（c）流通电池，其配置和尺寸设置为接收一定量 的磁性颗粒保留在流通池内并允许液体流过流通池。 液体携带通过磁性颗粒捕获的分子或颗粒。 流通池的一部分插入气隙中。

    Magnetic bead manipulation and transport device
    3.
    发明申请
    Magnetic bead manipulation and transport device 有权
    磁珠操纵和运输装置

    公开(公告)号：US20050284817A1

    公开(公告)日：2005-12-29

    申请号：US11214571

    申请日：2005-08-30

    申请人： Victor Fernandez ,  Amar Rida ,  Martin Gijs

    发明人： Victor Fernandez ,  Amar Rida ,  Martin Gijs

    IPC分类号： B01F13/00 ,  B01F13/08 ,  B01L3/00 ,  B03C1/035 ,  B03C1/28 ,  C02F1/48 ,  G01N35/00

    CPC分类号： B03C1/035 ,  B01F13/0059 ,  B01F13/0818 ,  B01F2215/0037 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/043 ,  B03C1/288 ,  G01N27/745 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/2575

    摘要： A device for transporting magnetic or magnetisable microbeads (25) in a capillary chamber (14) comprises a permanent magnet (10) or an electromagnet (11) for subjecting the capillary chamber to a substantially uniform magnetic field, to apply a permanent magnetic moment to the microbeads (25). At least one planar coil (22) and preferably an array of overlapping coils are located adjacent to the capillary chamber (14) for applying a complementary magnetic field on the microbeads parallel or antiparallel to said substantially uniform magnetic field, to drive the microbeads. An arrangement is provided for switching the current applied to the coil(s) (22) to invert the field produced thereby, to selectively apply an attractive or repulsive driving force on the microbeads (25). The device is usable to transport microbeads for performing chemical and biochemical reactions or assay, as is done for instance in clinical chemistry assays for medical diagnostic purposes.

    摘要翻译： 用于在毛细管室（14）中传送磁性或可磁化微珠（25）的装置包括永磁体（10）或电磁体（11），用于对毛细管腔进行基本均匀的磁场，以将永久磁矩施加到 微珠（25）。 至少一个平面线圈（22）并且优选地是重叠线圈阵列位于毛细管室（14）附近，用于在平行或反平行于所述基本上均匀的磁场的微珠上施加互补磁场，以驱动微珠。 提供一种用于切换施加到线圈（22）的电流以反转由此产生的场的布置，以选择性地在微珠（25）上施加有吸引力或排斥力的驱动力。 该装置可用于运输微珠进行化学和生物化学反应或测定，如在用于医学诊断目的的临床化学测定中所进行的那样。

    Magnetic bead manipulation and transport device
    4.
    发明授权
    Magnetic bead manipulation and transport device 有权
    磁珠操纵和运输装置

    公开(公告)号：US07309439B2

    公开(公告)日：2007-12-18

    申请号：US11214571

    申请日：2005-08-30

    申请人： Victor Fernandez ,  Amar Rida ,  Martin Gijs

    发明人： Victor Fernandez ,  Amar Rida ,  Martin Gijs

    IPC分类号： B01D35/06 ,  G01N33/553

    CPC分类号： B03C1/035 ,  B01F13/0059 ,  B01F13/0818 ,  B01F2215/0037 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/043 ,  B03C1/288 ,  G01N27/745 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/2575

    摘要： A device for transporting magnetic or magnetizable microbeads (25) in a capillary chamber (14) comprises a permanent magnet (10) or an electromagnet (11) for subjecting the capillary chamber to a substantially uniform magnetic field, to apply a permanent magnetic moment to the microbeads (25). At least one planar coil (22) and preferably an array of overlapping coils are located adjacent to the capillary chamber (14) for applying a complementary magnetic field on the microbeads parallel or antiparallel to said substantially uniform magnetic field, to drive the microbeads. An arrangement is provided for switching the current applied to the coil(s) (22) to invert the field produced thereby, to selectively apply an attractive or repulsive driving force on the microbeads (25). The device is usable to transport microbeads for performing chemical and biochemical reactions or assay, as is done for instance in clinical chemistry assays for medical diagnostic purposes.

    摘要翻译： 用于在毛细管室（14）中传送磁性或可磁化微珠（25）的装置包括永磁体（10）或电磁体（11），用于对毛细管腔进行基本均匀的磁场，以将永久磁矩施加到 微珠（25）。 至少一个平面线圈（22）并且优选地是重叠线圈阵列位于毛细管室（14）附近，用于在平行或反平行于所述基本上均匀的磁场的微珠上施加互补磁场，以驱动微珠。 提供一种用于切换施加到线圈（22）的电流以反转由此产生的场的布置，以选择性地在微珠（25）上施加有吸引力或排斥力的驱动力。 该装置可用于运输微珠进行化学和生物化学反应或测定，如在用于医学诊断目的的临床化学测定中所进行的那样。

    Magnetic Bead Retention Apparatus and Method
    7.
    发明申请
    Magnetic Bead Retention Apparatus and Method 审中-公开
    磁珠保留装置及方法

    公开(公告)号：US20100252507A1

    公开(公告)日：2010-10-07

    申请号：US12160942

    申请日：2006-01-26

    申请人： Frederic Lacharme ,  Martin Gijs

    发明人： Frederic Lacharme ,  Martin Gijs

    IPC分类号： B03C1/00 ,  B03C1/30

    CPC分类号： B03C1/288 ,  B03C2201/26

    摘要： An apparatus for retaining magnetic particles in self-assembled magnetic particle structures in a liquid flow, comprises a micro-channel (5) and magnets (1,2) for generating a substantially static magnetic field across the micro-channel (5) such that magnetic particles (12) suspended in a liquid in the micro-channel (5) form magnetic particle structures (15). The micro-channel (5) has along its length transverse large sections (8) alternating with narrow sections (9). The large sections (8) are periodically distributed along and on either side of the narrow sections (9) so that in use magnetic particle structures (15) form across the large sections (8) of the micro-channel (5), the magnetic particle structures being retained by engagement of end parts (18) of the magnetic particle structures in the large sections (8) of the cell or channel (5). The apparatus is useful in particular in life science, chemistry and microfiltration applications by flowing through the micro-channel (5) a fluid carrying molecules or particles to be captured, filtered or activated by the magnetic structures (15).

    摘要翻译： 用于将液体流中的自组装磁性颗粒结构中的磁性颗粒保持的装置包括用于在微通道（5）上产生基本上静态的磁场的微通道（5）和磁体（1,2），使得 悬浮在微通道（5）中的液体中的磁性颗粒（12）形成磁性颗粒结构（15）。 微通道（5）沿着其长度具有与窄部分（9）交替的横向大截面（8）。 大部分（8）沿着狭窄部分（9）的两侧周期地分布，使得在使用中，磁性颗粒结构（15）横跨微通道（5）的大部分（8）形成，磁性 颗粒结构通过在电池或通道（5）的大部分（8）中的磁性颗粒结构的端部（18）的接合而保持。 该装置特别在生命科学，化学和微量过滤应用中有用，通过流过微通道（5）流体携带由磁结构（15）捕获，过滤或活化的分子或颗粒。

    Method of manufacturing discrete electronic components
    8.
    发明授权
    Method of manufacturing discrete electronic components 失效
    制造离散电子元件的方法

    公开(公告)号：US06844804B2

    公开(公告)日：2005-01-18

    申请号：US10697440

    申请日：2003-10-31

    申请人： Martin Gijs

    发明人： Martin Gijs

    IPC分类号： H01F17/00 ,  H01F27/28 ,  H01F27/29 ,  H01F41/02 ,  H01F5/00

    CPC分类号： H01F41/02 ,  H01F17/0006 ,  H01F27/2804 ,  H01F27/292 ,  Y10T29/41 ,  Y10T29/49016 ,  Y10T29/49018 ,  Y10T29/4902 ,  Y10T29/49071

    摘要： The manufacturing method for components of the inductive type, in particular inductance coils, transformers or antennae, consists in making by micro-machining simultaneously on a first substrate made of magnetic material a plurality of first parts (1) connected to each other by connecting elements (2) or a connecting support, inserting on the arms (8a, 8b, 8c) of these first parts (1) a printed multi-layered plate (4, 5) having openings for the arms and metal windings ending in at least two contact pads (7a, 7b), in placing and securing a second substrate made of magnetic material on the first substrate and the plate, said second substrate having undergone micro-machining to obtain second parts (13) complementary to the first parts. These second parts are connected to each other by connecting elements or a connecting support. Then, the components are separated and, in a particular implementation, the contact pads arranged on tongues (16, 18) of said plate are folded against a base (9) of the core or of the magnetic circuit to from a surface mounting device.

    摘要翻译： 电感型的部件，特别是电感线圈，变压器或天线的部件的制造方法，在于通过在由磁性材料制成的第一基板上同时进行微加工而形成多个通过连接元件彼此连接的第一部分（1） （2）或连接支撑件，在这些第一部分（1）的臂（8a，8b，8c）上插入具有用于臂和金属绕组的开口的印刷多层板（4,5），其结束于至少两个 接触焊盘（7a，7b），在第一基板和板上放置并固定由磁性材料制成的第二基板，所述第二基板经过微加工以获得与第一部分互补的第二部分（13）。 这些第二部分通过连接元件或连接支撑件相互连接。 然后，组件被分离，并且在特定实施方式中，布置在所述板的舌部（16,18）上的接触垫相对于芯部或磁路的基座（9）折叠到表面安装装置。

    Method of manufacturing discrete electronic components
    9.
    发明授权
    Method of manufacturing discrete electronic components 有权
    制造离散电子元件的方法

    公开(公告)号：US06704994B1

    公开(公告)日：2004-03-16

    申请号：US09889739

    申请日：2001-07-20

    申请人： Martin Gijs

    发明人： Martin Gijs

    IPC分类号： H01P1100

    CPC分类号： H01F41/02 ,  H01F17/0006 ,  H01F27/2804 ,  H01F27/292 ,  Y10T29/41 ,  Y10T29/49016 ,  Y10T29/49018 ,  Y10T29/4902 ,  Y10T29/49071

    摘要： The manufacturing method for components of the inductive type, in particular inductance coils, transformers or antennae, consists in making by micro-machining simultaneously on a first substrate made of magnetic material a plurality of first parts (1) connected to each other by connecting elements (2) or a connecting support, inserting on the arms (8a, 8b, 8c) of these first parts (1) a printed multi-layered plate (4, 5) having openings for the arms and metal windings ending in at least two contact pads (7a, 7b), in placing and securing a second substrate made of magnetic material on the first substrate and the plate, said second substrate having undergone micro-machining to obtain second parts (13) complementary to the first parts. These second parts are connected to each other by connecting elements or a connecting support. Then, the components are separated and, in a particular implementation, the contact pads arranged on tongues (16, 18) of said plate are folded against a base (9) of the core or of the magnetic circuit to form a surface mounting device (SMD).

    摘要翻译： 电感型的部件，特别是电感线圈，变压器或天线的部件的制造方法，在于通过在由磁性材料制成的第一基板上同时进行微加工而形成多个通过连接元件彼此连接的第一部分（1） （2）或连接支撑件，在这些第一部分（1）的臂（8a，8b，8c）上插入具有用于臂和金属绕组的开口的印刷多层板（4,5），其结束于至少两个 接触焊盘（7a，7b），在第一基板和板上放置并固定由磁性材料制成的第二基板，所述第二基板经过微加工以获得与第一部分互补的第二部分（13）。 这些第二部分通过连接元件或连接支撑件相互连接。 然后，组件被分离，并且在具体实现中，布置在所述板的舌部（16,18）上的接触垫被折叠抵靠芯或磁路的基座（9），以形成表面安装装置 SMD）。