公开(公告)号：US20070270927A1

公开(公告)日：2007-11-22

申请号：US11750597

申请日：2007-05-18

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0565

Abstract: An implantable electrode comprising a substrate supporting microscopic surface structures such as columnar titanium nitride and further having nanoscopic surface structures on titanium nitride deposited on the exposed surface of the microscopic columnar structures is described. This is done through physical vapor deposition (PVD) and is based upon a relatively abrupt change in the surface mobility of the depositing material with a consequential variation in nucleation site density and surface mobility. At low mobility, there are increased nucleation sites and the condensation features are more numerous and finer. As mobility of the deposited species increases, the nucleation sites in the condensate film become fewer with coarser features. Consequently, the change from a relatively coarse microscopic surface structure to a relatively fine nanoscopic surface structure is accomplished by abruptly changing the total gas pressure in the processing chamber within a relatively short period of time of about ten seconds, or less.

Abstract translation: 描述了一种可植入电极，其包括支撑诸如柱状氮化钛的微观表面结构的基底，并且还在纳米级表面结构上沉积在微观柱状结构的暴露表面上的氮化钛上。 这是通过物理气相沉积（PVD）完成的，并且基于沉积材料的表面迁移率的相对突然的变化，并导致成核位点密度和表面迁移率的相应变化。 在低流动性下，增加了核化点，缩合特征更加多样化。 随着沉积物质的迁移率增加，冷凝膜中的成核位置随着较粗糙的特征变得更少。 因此，从相当粗糙的微观表面结构到相对精细的纳米表面结构的变化是通过在大约十秒或更短的相对短的时间段内突然改变处理室中的总气体压力来实现的。

公开(公告)号：US20140034484A1

公开(公告)日：2014-02-06

申请号：US13563282

申请日：2012-07-31

Applicant: Andrew E. Fisk ,  Vasyliy I. Maslov ,  Alexey A. Goncharov

Inventor： Andrew E. Fisk ,  Vasyliy I. Maslov ,  Alexey A. Goncharov

IPC: C23C14/24

CPC classification number: C23C14/325 ,  C23C14/564 ,  H01J37/32055 ,  H01J37/32422 ,  H01J37/3266 ,  H01J37/32871

Abstract: A method and apparatus for depositing a metal onto a substrate using a cathodic arc plasma source as a source of metal ions. A plasma deposition apparatus has a vacuum chamber; and a conduit within the vacuum chamber having an input end and an output end. A substrate is within the vacuum chamber, positioned to receive a plasma at the output end of the conduit. A cathodic arc plasma source within the vacuum chamber is positioned to inject a composition comprising a mixture of a plasma and electrons into the input end of the conduit toward the output end of the conduit. A magnetic field generator establishes a magnetic field within the conduit a plurality of electrodes located within the magnetic field and an electric field generator establishes an electric field within the conduit. The apparatus reduces or eliminates liquid metal droplets emitted from such a plasma source.

Abstract translation: 一种使用阴极电弧等离子体源作为金属离子源将金属沉积到衬底上的方法和装置。 等离子体沉积设备具有真空室; 并且真空室内的导管具有输入端和输出端。 基板位于真空室内，定位成在导管的输出端处接收等离子体。 定位在真空室内的阴极电弧等离子体源，以将包含等离子体和电子的混合物的组合物注入导管的输入端，以朝向导管的输出端。 磁场发生器在导管内建立位于磁场内的多个电极的磁场，并且电场发生器在导管内建立电场。 该装置减少或消除从这种等离子体源发射的液体金属液滴。

公开(公告)号：US20080299309A1

公开(公告)日：2008-12-04

申请号：US11754601

申请日：2007-05-29

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: C23C18/31

CPC classification number: C23C14/0036 ,  A61L31/082 ,  A61N1/05 ,  C23C14/352 ,  H01J37/3405 ,  H01J37/342

Abstract: A method of producing a coating for a medical device having high surface area and low porosity. The coating is formed by a PVD process in which a primary metallic component is deposited in the presence of a secondary reactive component in a high energy environment such that surface diffusion and intermixing can occur prior to the solidification of the condensate. The resulting coating consists of a zone 2 microstructure having a [1,1,1] crystal orientation, which provides a surface having well-defined pyramidal-shaped structures formed thereon.

Abstract translation: 一种生产具有高表面积和低孔隙率的医疗器械用涂层的方法。 涂层是通过PVD工艺形成的，其中在高能环境中在第二反应性组分的存在下沉积第一金属组分，使得表面扩散和混合可以在冷凝物凝固之前发生。 所得到的涂层由具有[1,1,1]晶体取向的区域2微结构组成，其提供具有形成在其上的明确限定的锥体结构的表面。

公开(公告)号：US20080299289A1

公开(公告)日：2008-12-04

申请号：US11868808

申请日：2007-10-08

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: B05D3/00 ,  A61N1/04

CPC classification number: C23C14/0036 ,  A61N1/05 ,  C23C14/0641 ,  C23C14/541

Abstract: A surface geometry for an implantable medical electrode that optimizes the electrical characteristics of the electrode and enables an efficient transfer of signals from the electrode to surrounding bodily tissue. The coating is optimized to increase the double layer capacitance and to lower the after-potential polarization for signals having a pulse width in a pre-determined range by keeping the amplitude of the surface geometry with a desired range.

Abstract translation: 用于可植入医疗电极的表面几何形状，其优化电极的电特性并且能够有效地将信号从电极传递到周围的身体组织。 优化涂层以通过将表面几何形状的幅度保持在期望的范围来增加双层电容并且降低具有预定范围的脉冲宽度的信号的后电位极化。

公开(公告)号：US09039963B2

公开(公告)日：2015-05-26

申请号：US13650877

申请日：2012-10-12

Applicant: Andrew E. Fisk ,  Anatolii Demchyshyn ,  Mykola Kuzmenko ,  Sergei Firstov ,  Leonid Kulak

Inventor： Andrew E. Fisk ,  Anatolii Demchyshyn ,  Mykola Kuzmenko ,  Sergei Firstov ,  Leonid Kulak

IPC: C22C14/00 ,  B22D25/06 ,  A61L31/12 ,  B22D7/00 ,  B22D21/00 ,  A61L31/02

CPC classification number: A61L31/124 ,  A61L31/022 ,  B22D7/005 ,  B22D21/005 ,  B22D25/06 ,  C22C14/00

Abstract: A titanium based, ceramic reinforced alloy ingot for use in producing medical implants. An ingot is formed from an alloy having comprising from about 5 to about 35 wt. % niobium, from about 0.5 to about 3.5 wt. % silicon, and from about 61.5 to about 94.5 wt. % of titanium. The alloy has a hexagonal crystal lattice α phase of from about 20 vol % to about 70 vol %, and a cubic body centered β crystal lattice phase of from about 30 vol. % to about 80 vol. %. The ingot has an ultimate tensile strength of about 940 MPa or more, and a Young's modulus of about 150 GPa or less. A molten substantially uniform admixture of a niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into an ingot. The ingot may then be formed into a medical implant and optionally annealed.

Abstract translation: 用于生产医疗植入物的钛基陶瓷增强合金锭。 锭由合金形成，该合金包含约5至约35重量％ ％铌，约0.5-约3.5wt。 ％硅，和约61.5至约94.5wt。 ％的钛。 该合金具有约20体积％至约70体积％的六方晶系晶格α相和以体积为中心的立方体。 晶格相约为30体积％。 ％至约80体积％ ％。 该锭的极限拉伸强度为约940MPa以上，杨氏模量为约150GPa以下。 形成熔融的大体均匀的铌，硅和钛合金的混合物，铸成一种形状并冷却成锭。 然后可以将锭形成医疗植入物并任选地退火。

公开(公告)号：US20120093707A1

公开(公告)日：2012-04-19

申请号：US13087440

申请日：2011-04-15

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: C01B21/076 ,  C01B21/06

CPC classification number: C23C14/0036 ,  A61N1/05 ,  C23C14/0641 ,  C23C14/541

Abstract: A surface geometry for an implantable medical electrode that optimizes the electrical characteristics of the electrode and enables an efficient transfer of signals from the electrode to surrounding bodily tissue. The coating is optimized to increase the double layer capacitance and to lower the after-potential polarization for signals having a pulse width in a pre-determined range by keeping the amplitude of the surface geometry with a desired range.

Abstract translation: 用于可植入医疗电极的表面几何形状，其优化电极的电特性并且能够有效地将信号从电极传递到周围的身体组织。 优化涂层以通过将表面几何形状的幅度保持在期望的范围来增加双层电容并且降低具有预定范围的脉冲宽度的信号的后电位极化。

公开(公告)号：US07812691B1

公开(公告)日：2010-10-12

申请号：US12267932

申请日：2008-11-10

Applicant: Andrew E. Fisk ,  Richard X. Fu ,  Christine A. Frysz

Inventor： Andrew E. Fisk ,  Richard X. Fu ,  Christine A. Frysz

IPC: H03H7/00

CPC classification number: H03H1/0007

Abstract: A feedthrough filter capacitor assembly is described. The feedthrough filter capacitor assembly comprises an outer ferrule hermetically sealed to an insulator of a dielectric material seated within the ferrule. The insulative material is also hermetically sealed to at least one lead wire. Instead of being made of platinum or platinum/iridium, the lead wire comprises a core of a non-noble metal supporting a functionally graded coating. The metal core has an inner layer of the same the non-noble metal of the core and an outer layer of a noble metal. A gradient transition zone exists between the non-noble metal and the outer noble metal. Consequently, lead wires having all the beneficial attributes of platinum and platinum/iridium wire can be built into hermetic feedthroughs, but at a significantly reduced cost. In a preferred form, a filter capacitor is mounted on the insulator and electrically connected to the lead wires and to the ferrule to prevent unwanted EMI signals from traveling along the wires and entering the interior of the medical device.

Abstract translation: 描述了馈通滤波电容器组件。 馈通滤波电容器组件包括密封到位于套圈内的介电材料的绝缘体的外套圈。 绝缘材料也与至少一根导线密封。 引线包括不支持铂或铂/铱的非贵金属的芯，而不支撑功能梯度的涂层。 金属芯具有与芯的非贵金属相同的内层和贵金属的外层。 在非贵金属和外部贵金属之间存在梯度过渡区。 因此，具有铂和铂/铱丝的所有有益属性的导线可以被构建在气密馈通中，但是显着降低成本。 在优选形式中，滤波电容器安装在绝缘体上并电连接到引线和套圈，以防止不必要的EMI信号沿着导线行进并进入医疗装置的内部。

公开(公告)号：US08948881B2

公开(公告)日：2015-02-03

申请号：US11750597

申请日：2007-05-18

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0565

Abstract: An implantable electrode comprising a substrate supporting microscopic surface structures such as columnar titanium nitride and further having nanoscopic surface structures on titanium nitride deposited on the exposed surface of the microscopic columnar structures is described. This is done through physical vapor deposition (PVD) and is based upon a relatively abrupt change in the surface mobility of the depositing material with a consequential variation in nucleation site density and surface mobility. At low mobility, there are increased nucleation sites and the condensation features are more numerous and finer. As mobility of the deposited species increases, the nucleation sites in the condensate film become fewer with coarser features. Consequently, the change from a relatively coarse microscopic surface structure to a relatively fine nanoscopic surface structure is accomplished by abruptly changing the total gas pressure in the processing chamber within a relatively short period of time of about ten seconds, or less.

Abstract translation: 描述了一种可植入电极，其包括支撑诸如柱状氮化钛的微观表面结构的基底，并且还在纳米级表面结构上沉积在微观柱状结构的暴露表面上的氮化钛上。 这是通过物理气相沉积（PVD）完成的，并且基于沉积材料的表面迁移率的相对突然的变化，并导致成核位点密度和表面迁移率的相应变化。 在低流动性下，增加了核化点，缩合特征更加多样化。 随着沉积物质的迁移率增加，冷凝膜中的成核位置随着较粗糙的特征变得更少。 因此，从相当粗糙的微观表面结构到相对精细的纳米表面结构的变化是通过在大约十秒或更短的相对短的时间段内突然改变处理室中的总气体压力来实现的。

公开(公告)号：US20140357973A1

公开(公告)日：2014-12-04

申请号：US13905851

申请日：2013-05-30

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: A61B5/04 ,  B23K26/36 ,  A61N1/05

Abstract: A biocompatible, implantable electrode for electrically active medical devices. The implantable medical electrode has a surface geometry which optimizes the electrical performance of the electrode, while mitigating the undesirable effects associated with prior art porous surfaces. The electrode has an optimized surface topography for improved electrical performance. Such a electrode is suitable for devices which may be permanently implanted in the human body as stimulation electrodes, such as pacemakers, or as sensors of medical conditions. Such is achieved by the application of ultrafast high energy pulses to the surface of a solid, monolithic electrode material for the purpose of increasing the surface area and thereby decreasing its after-potential polarization.

Abstract translation: 一种用于电活动医疗设备的生物相容性可植入电极。 可植入医疗电极具有优化电极的电性能的表面几何形状，同时减轻与现有技术多孔表面相关的不期望的影响。 电极具有优化的表面形貌，以改善电气性能。 这样的电极适用于作为刺激电极（例如起搏器）或作为医疗条件的传感器而永久地植入人体内的装置。 这是通过将超快速高能脉冲应用于固体单块电极材料的表面来实现的，目的是增加表面积，从而降低其后电位极化。

公开(公告)号：US20120094024A1

公开(公告)日：2012-04-19

申请号：US13087435

申请日：2011-04-15

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: B05D5/00 ,  B05D3/00

CPC classification number: C23C14/0036 ,  A61N1/05 ,  C23C14/0641 ,  C23C14/541

Abstract: A surface geometry for an implantable medical electrode that optimizes the electrical characteristics of the electrode and enables an efficient transfer of signals from the electrode to surrounding bodily tissue. The coating is optimized to increase the double layer capacitance and to lower the after-potential polarization for signals having a pulse width in a pre-determined range by keeping the amplitude of the surface geometry with a desired range.