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公开(公告)号：US20100160246A1
公开(公告)日：2010-06-24
申请号：US12089797
申请日：2007-10-10
IPC分类号： A61K31/704 , A61P35/00 , A61K31/4745
CPC分类号： A61K9/0085 , A61K9/16 , A61K9/1635 , A61K31/14 , A61K31/4745 , A61K31/704 , A61K31/734 , C08B37/0006
摘要： There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumour, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumours are also provided.
摘要翻译： 提供了新的使用的微球，其包含水不溶性的水溶胀性聚合物，其在pH7下被阴离子充电，并且与可聚合物静电相关的聚合物与阳离子电荷的化学治疗剂在制造用于使用的组合物中 在治疗脑肿瘤中，其中在治疗中将组合物引入脑中，并且化学治疗剂从微球释放，其中当在37℃的水中平衡时，微球包含至少40重量％的水 基于聚合物加水的重量。 还提供了包含微球的组合物和治疗脑肿瘤的方法。
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公开(公告)号：US08691791B2
公开(公告)日：2014-04-08
申请号：US12089797
申请日：2007-10-10
IPC分类号： A61K9/16 , A61K31/734 , C08B37/04 , C08B37/00
CPC分类号： A61K9/0085 , A61K9/16 , A61K9/1635 , A61K31/14 , A61K31/4745 , A61K31/704 , A61K31/734 , C08B37/0006
摘要： There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumor, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumors are also provided.
摘要翻译： 提供了新的使用的微球，其包含水不溶性的水溶胀性聚合物，其在pH7下被阴离子充电，并且与可聚合物静电相关的聚合物与阳离子电荷的化学治疗剂在制造用于使用的组合物中 在治疗脑肿瘤中，其中在治疗中将组合物引入脑中，并且化学治疗剂从微球释放，其中当在37℃的水中平衡时，微球包含至少40重量％的水 基于聚合物加水的重量。 还提供了包含微球的组合物和治疗脑肿瘤的方法。
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公开(公告)号：US20120276151A1
公开(公告)日：2012-11-01
申请号：US13282953
申请日：2011-10-27
申请人： Andrew Lennard Lewis , Peter William Stratford , Maria Victoria Gonzalez. Fajardo , Yiqing Tang
发明人： Andrew Lennard Lewis , Peter William Stratford , Maria Victoria Gonzalez. Fajardo , Yiqing Tang
IPC分类号： A61K9/14 , A61P35/00 , A61K31/4745 , A61P35/04 , B82Y5/00
CPC分类号： A61K31/4745 , A61K9/1635 , A61L24/0015 , A61L24/06 , A61L2300/416 , A61L2300/434 , A61L2300/622 , A61L2430/36 , C08L29/04
摘要： An embolic composition comprises microspheres formed of water-insoluble water-swellable anionic polymer having swollen diameter more than 100 μm and a cationic camptothecin compound, preferably irinotecan. The microspheres are preferably formed of crosslinked polyvinylalcohol, preferably of ethylenically unsaturated polyvinylalcohol macromer, crosslinked with anionic ethylenically unsaturated anionic comonomer. The compositions are used to treat hypervascular tumours for instance colorectal metastases of the liver.
摘要翻译： 栓塞组合物包含由具有大于100μm的溶胀直径的水不溶性水溶胀性阴离子聚合物和阳离子喜树碱化合物，优选伊立替康形成的微球。 微球优选由交联的聚乙烯醇，优选烯属不饱和聚乙烯醇大分子单体形成，与阴离子烯属不饱和阴离子共聚单体交联。 组合物用于治疗高血管肿瘤，例如肝脏的结肠直肠转移。
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公开(公告)号：US20110151013A1
公开(公告)日：2011-06-23
申请号：US12991321
申请日：2009-05-14
IPC分类号： A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00
CPC分类号： A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译： 本发明提供包含囊泡并包封在囊泡内的组合物，其包含小于1000个核苷酸的核酸，其中囊泡包含具有亲水和疏水嵌段的两亲嵌段共聚物。 还提供了形成囊泡的方法和将核酸，特别是将iRNA递送到细胞中的方法。
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5.发明授权Anionic-cationic polyion complexes comprising zwitterionic monomer component 有权包含两性离子单体组分的阴离子阳离子聚阳离子络合物公开(公告)号：US06524569B1
公开(公告)日：2003-02-25
申请号：US09831753
申请日：2001-05-14
IPC分类号： A61K3174
CPC分类号： C08K9/12 , C08L57/04 , C08L57/12 , C08L2666/04
摘要： A polyion complex (PIC) is formed of an anionic soluble polymer formed from ethylenically unsaturated monomers including at least one anionic or monomer and a cationic soluble polymer formed from ethylenically unsaturated monomer including at least one cationic monomer, in which the monomers used to form at least one of the polymers comprise a zwitterionic monomer and in which the monomers used to form at least one of the polymers include non-ionic monomer, preferably C1-24 alkyl(meth)acrylate, in which the overall ratio of anionic groups to cationic groups in the PIC is in the range 1.5:1 to 1:1.5, and in which the polymers are combined in ratios to provide a PIC in which there are units derived from zwitterionic monomer in an amount in the range 1 to 70 mole % based on total monomer derived units in the PIC and there are units derived from non-ionic monomer in an amount in the range 0 to 60 mole % based on total monomer derived units in the PIC. The PIC is preferably swollen in water and is a flowable gel. The zwitterionic monomer is preferably 2-(methacyloyloxyethyl)-2′-(trimethylammoniumethyl)phosphate inner salt.
摘要翻译： 聚阴离子络合物（PIC）由阴离子可溶性聚合物形成，其由包含至少一种阴离子或单体的烯属不饱和单体和由包含至少一种阳离子单体的烯属不饱和单体形成的阳离子可溶性聚合物形成，其中用于在 至少一种聚合物包含两性离子单体，其中用于形成至少一种聚合物的单体包括非离子单体，优选C 1-4烷基（甲基）丙烯酸酯，其中阴离子基团与阳离子基团的总比例 在PIC中的范围为1.5:1至1:1.5，其中聚合物的比例组合以提供PIC，其中存在衍生自两性离子单体的单元，其量为1至70摩尔％，基于 PIC中的单体衍生单元总数，并且源自非离子单体的单元的量为基于PIC中单体衍生单元的0至60摩尔％。 PIC优选在水中溶胀并且是可流动的凝胶。 两性离子单体优选为2-（甲基氰基乙氧基乙基）-2' - （三甲基铵乙基）磷酸酯内盐。
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公开(公告)号：US08455003B2
公开(公告)日：2013-06-04
申请号：US13452337
申请日：2012-04-20
申请人： Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
发明人： Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
CPC分类号： A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要： A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译： 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒，并在其中吸收蒽环类。 适合地，聚合物是基于聚（乙烯醇）的聚合物，并且药物是多柔比星。
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公开(公告)号：US08221793B2
公开(公告)日：2012-07-17
申请号：US12210573
申请日：2008-09-15
申请人： Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
发明人： Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
CPC分类号： A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要： A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译： 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒，并在其中吸收蒽环类。 适合地，聚合物是基于聚（乙烯醇）的聚合物，并且药物是多柔比星。
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8.发明申请TREATMENT OF ACUTE MYOCARDIAL INFARCTION (AMI) USING ENCAPSULATED CELLS ENCODING AND SECRETING GLP-1 PEPTIDES OR ANALOGS THEREOF 审中-公开使用封闭细胞治疗急性心肌梗死（AMI），编码和分泌GLP-1肽或其模拟物公开(公告)号：US20110236431A1
公开(公告)日：2011-09-29
申请号：US13061404
申请日：2009-09-11
CPC分类号： C12N5/0663 , A61K9/5036 , A61K38/185 , A61K38/1866 , A61K38/195 , A61K38/204 , A61K38/2053 , A61K38/26 , A61K2035/126 , A61L27/227 , A61L27/3834 , A61L27/54 , A61L2300/25 , A61L2300/258 , A61L2300/414 , A61L2300/62 , A61L2300/64 , A61L2400/06 , C12N2510/02 , C12N2510/04 , A61K2300/00
摘要： The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, for the treatment of acute myocardial infarction (AMI or Ml), wherein the cells, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the treatment of acute myocardial infarction (AMI or Ml).
摘要翻译： 本申请涉及使用细胞，例如细胞。 间充质干细胞或间充质基质细胞或任何其它合适的细胞编码和分泌GLP-1，其片段或变体或包含GLP-1或其片段或变体的融合肽，用于治疗急性心肌梗塞（AMI 或M1），其中编码和分泌GLP-1，其片段或变体或包含GLP-1或其片段或变体的融合肽的细胞被包封在（球形）微胶囊中以防止免疫反应 要治疗的患者系统。 本申请还涉及这些（球形）微胶囊或含有这些细胞或（球形）微胶囊的药物组合物用于治疗急性心肌梗塞（AMI或M1）的用途。
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公开(公告)号：US09254258B2
公开(公告)日：2016-02-09
申请号：US12991321
申请日：2009-05-14
IPC分类号： A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00 , A61K9/127 , A61K48/00 , C12N15/11
CPC分类号： A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译： 本发明提供包含囊泡并包封在囊泡内的组合物，其包含小于1000个核苷酸的核酸，其中囊泡包含具有亲水和疏水嵌段的两亲性嵌段共聚物。 还提供了形成囊泡的方法和将核酸，特别是将iRNA递送到细胞中的方法。
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公开(公告)号：US20110293672A1
公开(公告)日：2011-12-01
申请号：US13132259
申请日：2009-11-25
IPC分类号： A61K9/14 , A61K31/136 , A61P35/00 , A61K31/436 , C07D491/22 , A61P1/18 , A61K31/704 , A61K31/4745
CPC分类号： A61K9/0019 , A61K9/1635 , A61K9/1652 , A61K31/00 , A61K31/337 , A61K31/436 , A61K31/4745 , A61K31/704
摘要： There is provided a composition comprising microspheres which comprise a water-insoluble, water-swellable polymer and associated with the polymer, in releasable form, a chemotherapeutic agent, for use in the treatment of a pancreatic tumour or cyst, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water, wherein the polymer is anionically charged at pH7 and the chemotherapeutic agent is cationically charged and electrostatically associated with the polymer. Also provided are methods of treating pancreatic tumours or cysts using this composition.
摘要翻译： 提供包含微球的组合物，其包含水不溶性的水溶胀性聚合物，并且与可释放形式的聚合物缔合，用于治疗胰腺肿瘤或囊肿的化学治疗剂，其中当平衡时所述微球体 在37℃的水中，包含基于聚合物加水重量的至少40wt％的水，其中聚合物在pH7下被阴离子充电，并且化学治疗剂被阳离子充电并与聚合物静电相关。 还提供了使用该组合物治疗胰腺肿瘤或囊肿的方法。
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