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公开(公告)号：US20120322795A1
公开(公告)日：2012-12-20
申请号：US13325564
申请日：2011-12-14
申请人： Angela BERRY , Zhidong CHEN , Stephane DE LOMBAERT , Michel Jose EMMANUEL , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Hidenori TAKAHASHI
发明人： Angela BERRY , Zhidong CHEN , Stephane DE LOMBAERT , Michel Jose EMMANUEL , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Hidenori TAKAHASHI
IPC分类号： A61K31/506 , C07D405/14 , C07D417/14 , C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/519 , C07D239/42 , A61K31/505 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D401/12 , A61K31/501 , A61K31/4709 , A61K31/427 , A61K31/541 , A61K31/444 , C07D403/12 , C07D513/04 , A61P9/00 , A61P9/10 , A61P29/00 , A61P37/08 , A61P11/00 , A61P13/12 , A61P35/00 , C07D405/10
CPC分类号： C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中A，B，C，R 1a，R 1b，R 2，R 3，R 4a和R 4b如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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2.发明申请公开(公告)号：US20110312932A1
公开(公告)日：2011-12-22
申请号：US13217480
申请日：2011-08-25
申请人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
发明人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC分类号： A61K31/422 , A61K31/428 , A61K31/42 , A61P25/04 , A61K31/427 , A61K31/433 , A61P29/00 , A61K31/4196 , A61K31/454
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20110071127A1
公开(公告)日：2011-03-24
申请号：US12956322
申请日：2010-11-30
申请人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher Francis PALMER , Nigel BLUMIRE
发明人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher Francis PALMER , Nigel BLUMIRE
IPC分类号： A61K31/5377 , C07D261/14 , A61K31/42 , C07D213/70 , A61K31/4402 , C07C321/28 , A61K31/216 , C07D277/36 , A61K31/426 , C07D413/12 , A61K31/4439 , C07D309/08 , A61K31/351 , C07D417/14 , C07D413/14 , A61P29/00 , A61P1/00 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20100081644A1
公开(公告)日：2010-04-01
申请号：US12564132
申请日：2009-09-22
申请人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
发明人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC分类号： A61K31/4196 , C07D413/12 , A61K31/422 , C07D417/12 , A61K31/41 , A61K31/454 , C07D249/14
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20110130431A1
公开(公告)日：2011-06-02
申请号：US13022866
申请日：2011-02-08
申请人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Renee M. ZINDELL , Nigel BLUMIRE , Chandana CHOWDHURY , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Christopher Francis PALMER , Malcolm TAYLOR
发明人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Renee M. ZINDELL , Nigel BLUMIRE , Chandana CHOWDHURY , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Christopher Francis PALMER , Malcolm TAYLOR
IPC分类号： A61K31/42 , C07D261/14 , C07D277/46 , C07D231/40 , C07D213/75 , C07C233/07 , C07D277/82 , C07D409/04 , C07D217/22 , A61K31/426 , A61K31/415 , A61K31/44 , A61K31/167 , A61K31/428 , A61K31/472 , A61P29/00
CPC分类号： C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20080039464A1
公开(公告)日：2008-02-14
申请号：US11781336
申请日：2007-07-23
申请人： Angela BERRY , Pier CIRILLO , Eugene HICKEY , Doris RIETHER , David Thomson , Monika ERMANN , James JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher PALMER , Nigel BLUMIRE
发明人： Angela BERRY , Pier CIRILLO , Eugene HICKEY , Doris RIETHER , David Thomson , Monika ERMANN , James JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher PALMER , Nigel BLUMIRE
IPC分类号： A61K31/5377 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/426 , A61P29/00 , C07D215/38 , C07D249/14 , C07D277/38 , C07D417/12 , C07D413/14 , C07D413/12 , C07D285/135 , C07D261/14 , C07D231/38 , A61P37/00 , A61P25/04 , A61K31/433 , A61K31/4439 , A61K31/47
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20130203729A1
公开(公告)日：2013-08-08
申请号：US13570432
申请日：2012-08-09
申请人： Todd BOSANAC , Angela BERRY , John David GINN , Tamara Denise HOPKINS , Sabine SCHLYER , Fariba SOLEYMANZADEH , John WESTBROOK , Maolin YU , Zhonghua ZHANG
发明人： Todd BOSANAC , Angela BERRY , John David GINN , Tamara Denise HOPKINS , Sabine SCHLYER , Fariba SOLEYMANZADEH , John WESTBROOK , Maolin YU , Zhonghua ZHANG
IPC分类号： C07D417/14 , C07D417/04 , C07D417/12
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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8.发明申请公开(公告)号：US20120010184A1
公开(公告)日：2012-01-12
申请号：US13238054
申请日：2011-09-21
申请人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
发明人： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC分类号： A61K31/422 , A61K31/433 , A61K31/428 , A61K31/426 , A61K31/42 , A61K31/4196 , C07D401/12 , C07D285/135 , C07D417/12 , C07D413/12 , C07D249/14 , C07D261/14 , C07D403/12 , A61P29/00 , A61K31/454
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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