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    Rab7 GTPase inhibitors and related methods of treatment
    1.
    发明授权
    Rab7 GTPase inhibitors and related methods of treatment 有权
    Rab7 GTPase抑制剂及相关治疗方法

    公开(公告)号：US08765803B1

    公开(公告)日：2014-07-01

    申请号：US13404921

    申请日：2012-02-24

    申请人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aubé ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

    发明人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aubé ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

    IPC分类号： A01N43/10 ,  A01N43/16

    CPC分类号： C07D495/04 ,  A61K31/381 ,  A61K45/06

    摘要： This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.

    摘要翻译： 本发明涉及化合物及其作为Rab7 GTPase的抑制剂或活化剂的用途，用于治疗或预防Rab 7 GTP酶相关疾病如神经病变，癌症，骨骼和脂质储存代谢疾病的发生。 本发明也适用于Rab7灭活或其蛋白质 - 蛋白质相互作用被调节以促进病原体的细胞内存活的感染性疾病。 所描述的化合物作为核苷酸结合的竞争性抑制剂，因此也可用作靶向其他小GTP酶的支架。 一方面，本发明的治疗方法用于治疗或预防遗传性感觉神经病发作，例如Charcot-Marie-Tooth 2B型疾病。 还提供了相关的药物组合物，测定和药物筛选。

    Rab7 GTPase Inhibitors and Related Methods of Treatment
    2.
    发明申请
    Rab7 GTPase Inhibitors and Related Methods of Treatment 有权
    Rab7 GTPase抑制剂及相关治疗方法

    公开(公告)号：US20140248268A1

    公开(公告)日：2014-09-04

    申请号：US14278468

    申请日：2014-05-15

    申请人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aube ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

    发明人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aube ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

    IPC分类号： C07D495/04 ,  A61K45/06 ,  A61K31/381

    CPC分类号： C07D495/04 ,  A61K31/381 ,  A61K45/06

    摘要： This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.

    摘要翻译： 本发明涉及化合物及其作为Rab7 GTPase的抑制剂或活化剂的用途，用于治疗或预防Rab 7 GTP酶相关疾病如神经病变，癌症，骨骼和脂质储存代谢疾病的发生。 本发明也适用于Rab7灭活或其蛋白质 - 蛋白质相互作用被调节以促进病原体的细胞内存活的感染性疾病。 所描述的化合物作为核苷酸结合的竞争性抑制剂，因此也可用作靶向其他小GTP酶的支架。 一方面，本发明的治疗方法用于治疗或预防遗传性感觉神经病发作，例如Charcot-Marie-Tooth 2B型疾病。 还提供了相关的药物组合物，测定和药物筛选。

    Decorative architectural element and method for making
    5.
    发明申请
    Decorative architectural element and method for making 审中-公开
    装饰建筑元素和制作方法

    公开(公告)号：US20110225917A1

    公开(公告)日：2011-09-22

    申请号：US12661360

    申请日：2010-03-16

    申请人： Jennifer Golden ,  Stephen J. Sexton

    发明人： Jennifer Golden ,  Stephen J. Sexton

    IPC分类号： E06B3/30 ,  B29C51/10 ,  B29C51/14 ,  E06B3/78

    CPC分类号： E06B3/7001 ,  B29C51/10 ,  B29C51/14 ,  B29C2795/002 ,  B29K2023/083 ,  B29L2031/724

    摘要： A method for making a decorative architectural element is disclosed, which includes the steps of designing a vacuum form mold forming a three dimensional decorative shape for the architectural element, cut a moldable plastic sheet in a size and shape to fit over the vacuum form mold, designing a color graphic, print the color graphic onto a vinyl wrap which corresponds in size and shape to fit over the vacuum form mold covered with the plastic sheet, vacuum forming the plastic sheet over the vacuum form mold and the vinyl wrap over the plastic sheet. The plastic sheet takes the shape of the vacuum form mold and the vinyl wrap adheres to the molded plastic sheet. The molded plastic sheet and the attached molded vinyl wrap are then removed from the vacuum mold. One arrangement includes the step of affixing the molded plastic sheet with the attached molded vinyl wrap to the architectural element. The molded vinyl wrap faces away from the architectural element, so that the color graphic printed on the vinyl wrap is visible. A decorative architectural element includes a basic architectural element, a molded plastic sheet fitting over the basic architectural element giving the architectural element a decorative shape, and a molded vinyl wrap molded over the molded plastic and facing away from the basic architectural element. The molded vinyl wrap is printed with a color graphic.

    摘要翻译： 公开了一种制造装饰性建筑构件的方法，其包括以下步骤：设计形成用于建筑构件的三维装饰形状的真空成型模具，将尺寸和形状的可模制塑料片材切割成适合于真空成型模具， 设计彩色图形，将颜色图形打印到乙烯基包装上，其尺寸和形状对应于适合覆盖在塑料片上的真空成型模具上，将真空成型模具上的塑料薄片和塑料薄片上的乙烯基薄膜 。 塑料薄片采用真空成型模具的形状，乙烯基薄膜粘附在模塑塑料薄片上。 然后将模制的塑料片和附着的模制的乙烯基包裹物从真空模具中取出。 一种布置包括将模制的塑料片与附着的模制的乙烯基缠绕固定到建筑元件的步骤。 模制的乙烯基覆盖物远离建筑元件，使得印刷在乙烯基缠绕上的彩色图形是可见的。 装饰性建筑元件包括基本的建筑元件，在基本建筑元件上装配的模制塑料片，其使得建筑元件具有装饰性形状，以及模制在模制塑料上并且远离基本建筑元件的乙烯基覆盖物。 模制的乙烯基包装印有彩色图形。