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公开(公告)号：US5135857A
公开(公告)日：1992-08-04
申请号：US729512
申请日：1991-07-12
申请人： Angelo Borghi , Giancarlo Lancini , Piero Antonini
发明人： Angelo Borghi , Giancarlo Lancini , Piero Antonini
CPC分类号： C12R1/365 , C07K9/008 , C12R1/51 , Y10S435/872 , Y10S435/886
摘要： The object of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candidus NRRL 3218.
摘要翻译： 本发明的目的是脱氨基甲基替卡立定衍生物，它可以通过利用诺卡氏菌（Nocardia orientalis）NRRL 2450或链霉菌NRRL 3218的培养物进行微生物转化获得良好的产率。
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2.发明授权Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex 失效选择性提高抗生素A / 16686复合物单一主要成分比例的方法
公开(公告)号：US5925550A
公开(公告)日：1999-07-20
申请号：US993729
申请日：1997-12-18
申请人： Giancarlo Lancini , Angelo Borghi , Piero Antonini
发明人： Giancarlo Lancini , Angelo Borghi , Piero Antonini
CPC分类号： C12P1/06
摘要： The present invention relates to a method for selectively enhancing the production of factors A.sub.2 and/or A.sub.3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A/16686 producing culture during fermentation.
摘要翻译： 本发明涉及一种用于选择性增强抗生素A / 16686的因子A2和/或A3生产以分离这些单一组分或富集上述组分的一种或两种中的复合物的方法，其包括加入适当的前体 在发酵期间产生A / 16686培养物的所需抗生素因子。
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公开(公告)号：US5064811A
公开(公告)日：1991-11-12
申请号：US655252
申请日：1991-02-13
申请人： Angelo Borghi , Giancarlo Lancini , Piero Antonini
发明人： Angelo Borghi , Giancarlo Lancini , Piero Antonini
IPC分类号： A23K20/195 , A61K38/00 , A61P31/04 , A61P43/00 , C07K9/00 , C12P21/02 , C12P21/04 , C12R1/365 , C12R1/51
摘要： The oject of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candiodus NRRL 3218.
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公开(公告)号：US5085990A
公开(公告)日：1992-02-04
申请号：US701355
申请日：1991-05-10
IPC分类号： C12P19/62 , A23K20/195 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7042 , A61K38/00 , A61P31/04 , C07H15/203 , C07H17/00 , C07K9/00 , C12N1/20 , C12P21/04 , C12R1/045
CPC分类号： C07K9/008 , A23K20/195 , A61K38/00 , Y10S435/827
摘要： The present invention relates to new teicoplanin-like antibiotics differing from the parent compound in the length of the acyl group.The compounds of the invention are obtained according to a microbiological process and possess an antimicrobiol activity mainly against gram positive bacteria.
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公开(公告)号：US4042683A
公开(公告)日：1977-08-16
申请号：US601559
申请日：1975-08-04
IPC分类号： C12P17/18 , A61K31/395 , A61P31/04 , C07D498/08 , C12P1/06 , C12R1/365 , A61K35/00
CPC分类号： C07D498/08 , Y10S435/872 , Y10S435/886
摘要： This invention is directed to rifamycin compounds which are produced by fermentation of Nocardia mediterranea ATCC 31064, ATCC 31065 or ATCC 31066 in an aqueous nutrient medium under aerobic conditions. These rifamycins are referred to as rifamycin P, rifamycin Q, rifamycin R and rifamycin U.
摘要翻译： 本发明涉及通过在需氧条件下在含水营养培养基中发酵诺卡氏菌ATCC 31064，ATCC 31065或ATCC 31066产生的利福霉素化合物。 这些利福霉素被称为利福霉素P，利福霉素Q，利福霉素R和利福霉素U.
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6.发明授权
公开(公告)号：US4263404A
公开(公告)日：1981-04-21
申请号：US745932
申请日：1976-11-29
IPC分类号： C12P17/18 , A61K31/395 , A61P31/04 , C07D498/08 , C12P1/06 , C12R1/365 , C07D491/06 , A61K35/74 , C12N1/20
CPC分类号： C07D498/08 , Y10S435/872 , Y10S435/886
摘要： Novel rifamycin compounds, designated P, Q, R and U, produced by the fermentation of mutant strains of Streptomyces mediterranei.
摘要翻译： 通过发酵Streptomyces mediterranei的突变株产生的新的利福霉素化合物，称为P，Q，R和U。
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公开(公告)号：US3987053A
公开(公告)日：1976-10-19
申请号：US582556
申请日：1975-05-29
申请人： Bruno Cavalleri , Giancarlo Lancini
发明人： Bruno Cavalleri , Giancarlo Lancini
IPC分类号： C07D417/04 , C07D233/91
CPC分类号： C07D417/04
摘要： 2-Nitroimidazole derivatives of the general formula ##SPC1##Wherein R is a lower alkyl group and Y is a member of the group consisting of --CH.sub.2 OH, --CHO, CH.sub.3 CO--, vinyl, formylvinyl, styryl, substituted iminomethyl, 2-benzimidazolyl and 5-amino-1,3,4-thiadiazol-2-yl. The term "lower alkyl" designates aliphatic groups of from 1 to 4 carbon atoms; the term "substituted iminomethyl" designates nitrogen-containing functional derivatives of the aldehydic group. The compounds have antimicrobial activity.
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公开(公告)号：US4276382A
公开(公告)日：1981-06-30
申请号：US718727
申请日：1976-08-30
CPC分类号： C12P1/04
摘要： The antibiotic gardimycin and process for producing said antibiotic by fermentation of strains belonging to the genus Actinoplanes.
摘要翻译： 抗生素gardimycin和通过发酵属于Actinplanes属的菌株产生所述抗生素的方法。
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公开(公告)号：US4022884A
公开(公告)日：1977-05-10
申请号：US596702
申请日：1975-07-17
CPC分类号： A61K35/74 , C07G11/00 , Y10S435/827
摘要： The antibiotic gardimycin and process for producing said antibiotic by fermentation of strains belonging to the genus Actinoplanes.
摘要翻译： 抗生素gardimycin和通过发酵属于Actinplanes属的菌株产生所述抗生素的方法。
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公开(公告)号：US4041168A
公开(公告)日：1977-08-09
申请号：US644382
申请日：1975-12-29
IPC分类号： C07D235/10 , A61K31/415 , A61K31/4164 , A61P33/02 , C07D233/88 , C07D233/91
CPC分类号： C07C255/00 , C07D233/88 , C07D233/91
摘要： The compound 5-[(1-hydroxy-1-methyl)ethyl]-1-methyl-2-nitroimidazole is valuable in combatting Trichomonas vaginalis infections in mammals.
摘要翻译： 化合物5 - [（1-羟基-1-甲基）乙基] -1-甲基-2-硝基咪唑对于与哺乳动物阴道毛滴虫感染有关。
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