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    Detection of hypoxia
    4.
    发明授权
    Detection of hypoxia 失效
    检测缺氧

    公开(公告)号：US5843404A

    公开(公告)日：1998-12-01

    申请号：US598752

    申请日：1996-02-08

    申请人： Cameron J. Koch ,  Edith M. Lord

    发明人： Cameron J. Koch ,  Edith M. Lord

    IPC分类号： G01N33/53 ,  A61B5/055 ,  A61K49/00 ,  A61K51/00 ,  C07D233/66 ,  C07D233/91 ,  C07K14/00 ,  C07K14/415 ,  C07K14/76 ,  C07K16/00 ,  C07K16/16 ,  C07K16/18 ,  C07K16/44 ,  G01N33/577 ,  G01T1/161 ,  A61K51/10 ,  A61K31/415 ,  A61K101/02 ,  G01N33/531

    CPC分类号： C07K16/44 ,  A61K49/001 ,  C07D233/91

    摘要： Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

    摘要翻译： 公开了包含新型硝基芳族化合物和载体蛋白质的新型硝基芳族化合物和免疫原性缀合物。 本发明还提供对所要求保护的硝基芳族化合物，化合物的蛋白质缀合物，化合物的还原副产物以及化合物和哺乳动物缺氧细胞组织蛋白质之间形成的加合物高度特异性的单克隆抗体。 本发明还涉及使用免疫组织化学技术，非侵入性核医学方法或核磁共振来检测组织缺氧的方法。 还提供了可用于实践所要求保护的发明的方法的诊断试剂盒。

    Method for making a polarographic oxygen sensor
    6.
    发明授权
    Method for making a polarographic oxygen sensor 失效
    制造极谱氧传感器的方法

    公开(公告)号：US5223123A

    公开(公告)日：1993-06-29

    申请号：US696199

    申请日：1991-05-06

    申请人： Cameron J. Koch

    发明人： Cameron J. Koch

    IPC分类号： G01N27/49

    CPC分类号： G01N27/404

    摘要： The cathode sub-assembly of a polarographic sensor comprises an elongate housing with a longitudinal opening therethrough and with noble metal wires extending completely through the opening, the wires held symmetrically in the longitudinal opening by an extensive plug of glass which is solidified in situ in sealing contact with the wires and with the wall of the longitudinal opening. A suitable tubular anode is provided through which the cathode sub-assembly protrudes, and a flexible membrane of an inert material, which is permeable to gas and impermeable to water vapor and other than gaseous dissolved solutes, is secured in sealed relationship over the anode and the cathode, with a film of electrolyte bathing the anode and the cathode and contained by the membrane.

    摘要翻译： 极谱传感器的阴极子组件包括具有穿过其中的纵向开口的细长壳体，并且贵金属电线完全延伸穿过开口，电线通过广泛的玻璃塞对称地保持在纵向开口中，该玻璃塞在密封中原位固化 与电线和纵向开口的壁接触。 提供了合适的管状阳极，阴极子组件通过该阳极子组件突出，并且惰性材料的柔性膜可透气并且不透水蒸气和不是气态溶解的溶质，并且在阳极上以密封的关系固定， 阴极，用电解液浸泡阳极和阴极并由膜包围。

    Methods For Differential Detection Of Hypoxic Tissue From A Tissue Sample Of A Mammalian Subject
    7.
    发明申请
    Methods For Differential Detection Of Hypoxic Tissue From A Tissue Sample Of A Mammalian Subject 审中-公开
    用于差异检测哺乳动物组织样本中缺氧组织的方法

    公开(公告)号：US20090117607A1

    公开(公告)日：2009-05-07

    申请号：US12262253

    申请日：2008-10-31

    申请人： Cameron J. Koch

    发明人： Cameron J. Koch

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/5091 ,  G01N33/5008

    摘要： Methods are provided for detecting levels of low oxygen in a tissue of a mammalian subject by administering non-polar halogen compounds to the mammalian subject. Detection may be accomplished using imaging methods involving fluorescence immunohistochemical imaging of the halogen compound.

    摘要翻译： 提供了通过向哺乳动物受试者施用非极性卤素化合物来检测哺乳动物受试者的组织中低氧水平的方法。 可以使用涉及卤素化合物的荧光免疫组织化学成像的成像方法来实现检测。

    Methods for diagnosis and treatment of tumors in humans
    8.
    发明授权
    Methods for diagnosis and treatment of tumors in humans 有权
    人体肿瘤诊断和治疗方法

    公开(公告)号：US06300136B1

    公开(公告)日：2001-10-09

    申请号：US09146401

    申请日：1998-09-03

    申请人： Cameron J. Koch ,  Sydney M. Evans

    发明人： Cameron J. Koch ,  Sydney M. Evans

    IPC分类号： G01N3348

    CPC分类号： G01N33/6815 ,  G01N33/574 ,  G01N2800/52 ,  Y10S436/813 ,  Y10T436/18 ,  Y10T436/182

    摘要： The invention relates to the discovery that the concentration of free cysteine in mammalian tumor tissue is elevated compared with the concentration of free cysteine in non-tumor tissue of the same origin. Elevated levels of free cysteine is, in turn, correlated with resistance of tumors to antitumor therapy such as chemotherapy and radiation therapy. Therefore, the invention further relates to methods of detecting the presence of tumors in mammalian tissues, assessing the resistance of tumors to antitumor therapies as it relates to free cysteine concentration, and to the identification of compounds which affect free cysteine concentration in mammalian tissues.

    摘要翻译： 本发明涉及与相同来源的非肿瘤组织中游离半胱氨酸的浓度相比，哺乳动物肿瘤组织中游离半胱氨酸浓度升高的发现。 游离半胱氨酸水平升高又与肿瘤对抗肿瘤治疗（如化学疗法和放射治疗）的抵抗力相关。 因此，本发明还涉及检测哺乳动物组织中肿瘤存在的方法，评估肿瘤对抗肿瘤疗法的抗性，因为它涉及游离半胱氨酸浓度，以及鉴定影响哺乳动物组织中游离半胱氨酸浓度的化合物。

    Polarographic oxygen sensor
    10.
    发明授权
    Polarographic oxygen sensor 失效
    极谱氧传感器

    公开(公告)号：US5030336A

    公开(公告)日：1991-07-09

    申请号：US403832

    申请日：1989-09-05

    申请人： Cameron J. Koch

    发明人： Cameron J. Koch

    IPC分类号： G01N27/49

    CPC分类号： G01N27/404

    摘要： The cathode sub-assembly of a polarographic sensor comprises an elongate housing with a longitudinal opening therethrough and with noble metal wires extending completely through the opening, the wires held symmetrically in the longitudinal opening by an extensive plug of glass which is solidified in situ in sealing contact with the wires and with the wall of the longitudinal opening. A suitable tubular anode is provided through which the cathode sub-assembly protrudes, and a flexible membrane of an inert material, which is permeable to gas and impermeable to water vapor and other than gaseous dissolved solutes, is secured in sealed relationship over the anode and the cathode, with a film of electrolyte bathing the anode and the cathode and contained by the membrane.

    摘要翻译： 极谱传感器的阴极子组件包括具有穿过其中的纵向开口的细长壳体，并且贵金属电线完全延伸穿过开口，电线通过广泛的玻璃塞对称地保持在纵向开口中，该玻璃塞在密封中原位固化 与电线和纵向开口的壁接触。 提供了合适的管状阳极，阴极子组件通过该阳极子组件突出，并且惰性材料的柔性膜可透气并且不透水蒸气和不是气态溶解的溶质，并且在阳极上以密封的关系固定， 阴极，用电解液浸泡阳极和阴极并由膜包围。