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公开(公告)号：US06960337B2
公开(公告)日：2005-11-01
申请号：US10298851
申请日：2002-11-15
IPC分类号： A61K31/56 , A61K31/568 , A61K38/24 , A61K9/12 , A61F2/02
CPC分类号： A61K31/56 , A61K31/568 , A61K38/24 , Y10S514/841 , Y10S514/843 , Y10S514/874 , A61K2300/00
摘要： An improvement in a method of treating benign gynecological disorders is described. In the method, treatment of a benign gynecological disorder with a composition comprised of a gonadotropin releasing hormone (GnRH) compound and an estrogenic compound, and optionally, an androgenic compound, is extended to premenopausal women who are not receiving an exogenously supplied progestin on a regular or periodic basis. Treatment in accord with the invention does not increase significantly the risk of endometrial hyperplasia. The method is also suitable for contraception.
摘要翻译： 描述了治疗良性妇科疾病的方法的改进。 在该方法中，将由促性腺激素释放激素（GnRH）化合物和雌激素化合物组成的组合物以及任选的雄激素化合物治疗的良性妇科疾病的治疗延伸至绝经后妇女，其不接受外源供应的孕激素 定期或定期的基础。 符合本发明的治疗不会显着增加子宫内膜增生的风险。 该方法也适用于避孕。
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公开(公告)号：US07029657B2
公开(公告)日：2006-04-18
申请号：US10295337
申请日：2002-11-15
CPC分类号： A61K31/56 , A61K31/715 , A61K31/724 , Y10S514/841 , Y10S514/843 , Y10S514/874 , A61K2300/00
摘要： The present invention relates to an improvement in a method of contraception, in treatment of benign gynecological disorders, and in hormone replacement. The improved method includes administering intranasally an estrogenic compound and an androgenic compound, and in some embodiments an optional progestin compound, in a once-daily bolus formulation comprised of the two or three steroids complexed with a cyclodextrin. An intranasal delivery system for administration of the formulation is also described.
摘要翻译： 本发明涉及在避孕方法，治疗良性妇科疾病和激素替代方面的改进。 改进的方法包括在由环糊精络合的两种或三种类固醇组成的每日一次的丸剂制剂中鼻内施用雌激素化合物和雄激素化合物，并且在一些实施方案中为任选的孕激素化合物。 还描述了用于给药该制剂的鼻内递送系统。
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公开(公告)号：US06958142B2
公开(公告)日：2005-10-25
申请号：US10298378
申请日：2002-11-15
IPC分类号： A61K9/00 , A61K31/565 , A61K31/724 , A61K38/24 , A61K47/40 , A61K9/12 , A61K31/56 , A61F2/02
CPC分类号： A61K47/40 , A61K9/0043 , A61K31/565 , A61K31/724 , A61K38/24 , G06F19/00 , Y10S514/874 , A61K2300/00
摘要： A nasal spray formulation for use in female contraception or in the treatment of benign gynecological disorders is described. The nasal preparation is comprised of a GnRH compound and an estrogenic compound in the form of a water-soluble complex with a water-soluble cyclodextrin. The preparation effectively suppresses ovarian estrogen and progesterone production, and prevents signs and symptoms of estrogen deficiency, without a significant increase in the risk of endometrial hyperplasia.
摘要翻译： 描述了用于女性避孕或治疗良性妇科疾病的鼻喷雾制剂。 鼻制剂由与水溶性环糊精的水溶性络合物形式的GnRH化合物和雌激素化合物组成。 该制剂有效抑制卵巢雌激素和孕激素的产生，并防止雌激素缺乏的体征和症状，而不会显着增加子宫内膜增生的风险。
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4.发明授权公开(公告)号：US06225298B1
公开(公告)日：2001-05-01
申请号：US08878690
申请日：1997-06-18
IPC分类号： A61K3156
CPC分类号： A61K31/565 , A61K31/57 , A61K31/58 , Y10S514/843 , A61K2300/00
摘要： Compositions and methods for use in preventing conception or treating benign gynecological disorders, wherein an effective amount of an antiprogestational agent [e.g., progesterone (progestin, progestogen, gestagen) antagonist or progesterone synthesis inhibitor] administered over a first period of time is combined with an effective amount of a progestogen for a second period of time. The antiprogestational agent is selected from single agents or mixtures thereof. The progestogen is selected from single agents or mixtures of natural or synthetic progestogens. The formulations are effective as contraceptive agents and for treatment of benign gynecological disorders including uterine fibroids, premenstrual syndrome, dysfunctional uterine bleeding, polycystic ovarian syndrome and endometriosis.
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公开(公告)号：US07273896B2
公开(公告)日：2007-09-25
申请号：US10412710
申请日：2003-04-10
IPC分类号： C08F2/46
摘要： This invention relates generally to compositions and systems for forming biomaterials containing a transient colorant for visualizing tissue or surgical materials coated with such biomaterials, to methods of using such compositions as bioadhesives, for tissue augmentation, in the prevention of surgical adhesions, for coating surfaces of synthetic implants, as drug delivery matrices, for ophthalmic applications, and in other applications.
摘要翻译： 本发明一般涉及用于形成生物材料的组合物和系统，所述组合物和系统包含用于可视化涂覆有这种生物材料的组织或手术材料的临时着色剂，使用这些组合物作为生物粘合剂，用于组织增强，防止手术粘连， 合成植入物，作为药物递送基质，用于眼科应用和其它应用。
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公开(公告)号：US4250139A
公开(公告)日：1981-02-10
申请号：US8652
申请日：1979-02-01
申请人： Edward E. Luck , John R. Daniels
发明人： Edward E. Luck , John R. Daniels
CPC分类号： A61L2/0011 , A61L2/12
摘要： Method for decontaminating proteinaceous host materials from microorganisms, while retaining chemical, physical and physiological properties of said host proteinaceous materials, said method comprising substantially dehydrating said host proteinaceous material, preferably by lyophilization, and subjecting said host material to a lethal dosage of microwave energy while said host material is maintained in substantially ambient conditions.
摘要翻译： 在保留所述宿主蛋白质材料的化学，物理和生理特性的同时，从微生物中净化蛋白质主体材料的方法，所述方法优选通过冻干干燥基本脱水所述宿主蛋白质材料，并使所述宿主材料经受致死剂量的微波能量，同时 所述主体材料保持在基本环境条件下。
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公开(公告)号：US4708718A
公开(公告)日：1987-11-24
申请号：US751605
申请日：1985-07-02
申请人： John R. Daniels
发明人： John R. Daniels
CPC分类号： A61L24/102 , C07K14/78 , A61F2310/00365 , A61K38/00 , Y10S128/08
摘要： A method of treating a solid tumor, including the steps of localizing the tumor and the arterial vessel that supplies it, and injecting into the vessel, a vaso-occlusive collagen material adapted to produce occlusion of vessels having lumen diameters between about 10 and 150 microns. The injected material is effective to produce occlusion of the secondary and tertiary vessels supplying the tumor, distal to the collateral blood vessels which may also supply the tumor. The region of the occluded tumor is heated under conditions that produce tissue necrosis selectively in the occluded tumor tissue.
摘要翻译： 一种治疗实体瘤的方法，包括定位肿瘤和给予肿瘤的动脉血管的步骤，以及向容器注射一种血管闭塞性胶原材料，其适于产生管腔直径在约10至150微米之间的血管闭塞 。 注射的材料有效地产生供给肿瘤的二级和三级血管的闭塞，远端也可能提供肿瘤的侧支血管。 闭塞肿瘤的区域在封闭的肿瘤组织中选择性地产生组织坏死的条件下加热。
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公开(公告)号：US4140537A
公开(公告)日：1979-02-20
申请号：US744536
申请日：1976-11-24
申请人： Edward E. Luck , John R. Daniels
发明人： Edward E. Luck , John R. Daniels
IPC分类号： A61F2/00 , A61K9/00 , A61L15/32 , A61L17/08 , A61L26/00 , A61L27/24 , A61L29/00 , B01D71/74 , C07K14/78 , C08L89/06 , D01D5/40 , D01F4/00
CPC分类号： A61K9/0024 , A61L15/325 , A61L17/08 , A61L26/0033 , A61L27/24 , B01D71/74 , C08L89/06 , D01D5/40 , D01F4/00 , A61F2310/00365
摘要： The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and are especially suitable for biologic implantation or application.
摘要翻译： 通过去除被描述为端肽的某些末端肽链修饰天然存在的胶原蛋白。 如此衍生的经修饰的胶原被描述为去糖肽胶原。 天然胶原蛋白是免疫原性的，而阿片肽胶原蛋白是非免疫原性的或具有可忽略的低水平的免疫原性。
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9.发明授权Method of using a radiolucent organ displacement device for radiation therapy 失效使用射线可穿透器官置换装置进行放射治疗的方法
公开(公告)号：US5653758A
公开(公告)日：1997-08-05
申请号：US469479
申请日：1995-06-06
申请人： John R. Daniels , Terry R. Knapp
发明人： John R. Daniels , Terry R. Knapp
CPC分类号： A61L27/50 , A61B90/00 , A61L27/18 , A61B2017/00902 , A61B2090/0815
摘要： A temporarily implantable organ displacement implant is comprised of a bladder with a one-way valve for being filled with a fluid for displacement of a healthy organ from a tissue site desired to be irradiated by radiation therapy. This organ displacement implant is substantially radiolucent which thereby facilitates its placement and minimizes its interference with the radiation therapy.
摘要翻译： 临时可植入器官置换植入物包括具有单向阀的囊，用于填充用于将健康器官从期望被辐射治疗照射的组织部位移位的流体。 该器官置换植入物基本上是可透射的，由此有利于其放置并使其与放射治疗的干扰最小化。
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公开(公告)号：US4813934A
公开(公告)日：1989-03-21
申请号：US83624
申请日：1987-08-07
申请人： Erick T. Engelson , John R. Daniels
发明人： Erick T. Engelson , John R. Daniels
CPC分类号： A61M25/0075 , A61M25/0125
摘要： A catheter device for accessing an internal body site along a small-diameter vessel path containing branch points in which the path may follow either the larger of smaller-diameter branch vessels. The device includes a catheter having a distal-end inflatable ballon and a distal-end aperture. A guide wire in the device is designed to block the aperture at one or more axial wire positions, allowing the balloon to be inflated by fluid infusion into the catheter. In a catheter placement operation, the catheter is advanced along the vessel path toward the selected target site. When the leading end of the catheter encounters a branch point at which the path follows the larger-diameter vessel, the guide wire is moved to a position which blocks the catheter aperture, and fluid is infused into the catheter to inflate the balloon. The catheter is then carried by hydrodynamic flow into the larger-diameter vessel. When the catheter end encounters a branch point at which the path follows the smaller diameter of the two branch vessels, the catheter is deflated and the guide wire manipulated to orient the wire for movement into the smaller vessel.
摘要翻译： 一种用于沿着包含分支点的小直径血管路径进入内部身体部位的导管装置，其中所述路径可以跟随较大直径的分支血管。 该装置包括具有远端充气气囊和远端孔的导管。 设备中的引导线被设计成在一个或多个轴向线位置处阻挡孔，允许气囊通过流体输注到导管中而膨胀。 在导管放置操作中，导管沿着血管路径前进到所选择的目标部位。 当导管的前端遇到路径跟随较大直径血管的分支点时，导线移动到阻挡导管孔的位置，并且流体注入导管以使气囊膨胀。 然后通过流体动力流将导管携带到较大直径的容器中。 当导管端部遇到分支点时，其中路径遵循两个分支血管的较小直径，导管被放气并且导丝被操纵以使丝线定向以移动到较小的血管中。
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