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    REFRESHING BEVERAGE
    2.
    发明申请
    REFRESHING BEVERAGE 审中-公开
    刷新饮料

    公开(公告)号：US20130287871A1

    公开(公告)日：2013-10-31

    申请号：US13978535

    申请日：2011-12-20

    申请人： Johannes Coy

    发明人： Johannes Coy

    IPC分类号： A23L2/52 ,  A61K31/7016 ,  A61K36/736 ,  A61K36/752 ,  A61K36/73 ,  A61K31/191

    CPC分类号： A23L2/52 ,  A23L2/60 ,  A23L2/68 ,  A61K31/191 ,  A61K31/7016 ,  A61K36/73 ,  A61K36/736 ,  A61K36/752

    摘要： The invention relates to a novel sweet-tasting refreshing beverage, which is free of phosphoric acid and instead contains at least 0.3% by weight/volume of gluconic acid, which is low in minerals, specifically contains less than 250 mg/liter of minerals, which is low in sugar, specifically contains at most 2.5% by weight/volume of sugar, wherein these sugars comprise at least 10% weight/weight galactose and in addition a proportion of isomaltulose and/or tagatose, and which has a glycemic index of at most 35 (GI

    摘要翻译： 本发明涉及一种新颖的甜味清新饮料，其不含磷酸，而是含有至少0.3重量％/体积的葡萄糖酸，其矿物质含量低，特别地含有少于250毫克/升的矿物质， 其糖含量低，特别地含有至多2.5％（重量）/糖的糖，其中这些糖包含至少10％重量/重量的半乳糖，另外还含有一定比例的异麦芽酮糖和/或塔格糖，其具有血糖指数 最多35（GI <35）。

    Marker molecules associated with lung tumors
    3.
    发明授权
    Marker molecules associated with lung tumors 有权
    与肺肿瘤相关的标记分子

    公开(公告)号：US07883896B2

    公开(公告)日：2011-02-08

    申请号：US12050002

    申请日：2008-03-17

    申请人： Johannes Coy ,  Rainer Hipfel ,  Birgit Wasser

    发明人： Johannes Coy ,  Rainer Hipfel ,  Birgit Wasser

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts of the gene disclosed herein, that are associated with tumors of the respiratory tract. Furthermore the present invention provides a method for early diagnosis, prognosis and monitoring of the disease course and for therapy and vaccination of cell proliferative disorders such as e.g. lung tumors.

    摘要翻译： 本发明涉及与肺癌相关的核酸和多肽。 本发明更具体地涉及核酸和转录的多肽，其表达与肺癌相关显着改变。 本发明涉及与本文所公开的基因的一系列差异拼接的转录本，其与呼吸道的肿瘤相关。 此外，本发明提供了一种用于早期诊断，预后和监测疾病进程以及用于治疗和接种细胞增殖性疾病的方法，所述方法包括： 肺肿瘤。

    COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF PROLIFERATIVE ABNORMALITIES ASSOCIATED WITH OVEREXPRESSION OF HUMAN TRANSKETOLASE LIKE-1 GENE
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF PROLIFERATIVE ABNORMALITIES ASSOCIATED WITH OVEREXPRESSION OF HUMAN TRANSKETOLASE LIKE-1 GENE 有权
    检测和治疗与人类转铁蛋白LIKE-1基因过表达相关的增殖异常的组合物和方法

    公开(公告)号：US20100136577A1

    公开(公告)日：2010-06-03

    申请号：US12615592

    申请日：2009-11-10

    申请人： Johannes Coy

    发明人： Johannes Coy

    IPC分类号： G01N33/573 ,  C12Q1/48

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： Methods for in vitro diagnosis of carcinoma are disclosed. In one aspect the invention relates to methods such as detecting the level of transketolase like-1 polypeptide, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.

    摘要翻译： 公开了体外诊断癌症的方法。 一方面，本发明涉及诸如检测转酮醇酶样-1多肽的水平的方法，其基于检测生物样品中人转酮酶样-1基因的过表达，特别可用于检测肿瘤及其前体阶段。 在另一方面，本发明涉及治疗与人类转酮酶样-1基因的过度表达相关的病症的方法。 治疗方法可以包括基因治疗方法以及抑制或降低转酮酶样-1多肽的活性的方法。

    Compositons and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene
    5.
    发明申请
    Compositons and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene 有权
    用于检测和治疗与人类转酮酶样-1基因过表达相关的增殖异常的复合物和方法

    公开(公告)号：US20050158726A1

    公开(公告)日：2005-07-21

    申请号：US10511813

    申请日：2003-04-12

    申请人： Johannes Coy

    发明人： Johannes Coy

    IPC分类号： G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N21/78 ,  G01N33/566 ,  G01N33/58 ,  C07K16/40 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： The present invention relates to methods for treatment and diagnosis of disorders associated with abnormally proliferating cells. In one aspect the invention relates to methods, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.

    摘要翻译： 本发明涉及用于治疗和诊断与异常增殖细胞相关的疾病的方法。 一方面，本发明涉及一种方法，其特别可用于基于检测生物样品中人转酮酶样-1基因的过表达来检测肿瘤及其前体阶段。 在另一方面，本发明涉及治疗与人类转酮酶样-1基因的过度表达相关的病症的方法。 治疗方法可以包括基因治疗方法以及抑制或降低转酮酶样-1多肽的活性的方法。

    Method for checking and controlling the mammalian lactic acid fermentation process / aerobic glucose fermentation metabolic pathway in mammalian organism
    6.
    发明授权
    Method for checking and controlling the mammalian lactic acid fermentation process / aerobic glucose fermentation metabolic pathway in mammalian organism 有权
    检测和控制哺乳动物生物体内哺乳动物乳酸发酵过程/需氧葡萄糖发酵代谢途径的方法

    公开(公告)号：US07754437B2

    公开(公告)日：2010-07-13

    申请号：US11571205

    申请日：2006-03-03

    申请人： Johannes Coy

    发明人： Johannes Coy

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/54 ,  C12Q1/48 ,  G01N1/30

    摘要： The method for qualitative and quantitative detecting of the extend of use and the correct process flow of the mammalian aerobic glucose fermentation metabolic pathway (mam-aGF) in a mammalian individual is characterized in that the enzyme TKTL1 is used as indicator and target molecule and that the structural and/or functional parameter of said TKTL1 in a biological sample of said individual (patient) are taken as indication for the qualitative and quantitative run of the mam-aGF in the cells and/or tissue of said individual (patient). In combination with the use of inhibitors and activators of that mam-aGF the method is further suitable for checking and controlling the mam-aGF in an individual (patient).

    摘要翻译： 在哺乳动物个体中定性和定量检测哺乳动物需氧葡萄糖发酵代谢途径（mam-aGF）的使用范围和正确工艺流程的方法的特征在于，使用TKTL1作为指示剂和靶分子， 将所述个体（患者）的生物样品中的所述TKTL1的结构和/或功能参数作为所述个体（患者）的细胞和/或组织中的mam-aGF的定性和定量运行的指示。 结合使用该mam-aGF的抑制剂和激活剂，该方法还适用于检查和控制个体（患者）中的mam-aGF。

    Marker molecules associated with lung tumors
    7.
    发明授权
    Marker molecules associated with lung tumors 有权
    与肺肿瘤相关的标记分子

    公开(公告)号：US07355025B2

    公开(公告)日：2008-04-08

    申请号：US10515477

    申请日：2003-05-16

    申请人： Johannes Coy ,  Rainer Hipfel ,  Birgit Wasser

    发明人： Johannes Coy ,  Rainer Hipfel ,  Birgit Wasser

    IPC分类号： C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts of the gene disclosed herein, that are associated with tumors of the respiratory tract. Furthermore the present invention provides a method for early diagnosis, prognosis and monitoring of the disease course and for therapy and vaccination of cell proliferative disorders such as e.g. lung tumors.

    摘要翻译： 本发明涉及与肺癌相关的核酸和多肽。 本发明更具体地涉及核酸和转录的多肽，其表达与肺癌相关显着改变。 本发明涉及与本文所公开的基因的一系列差异拼接的转录本，其与呼吸道的肿瘤相关。 此外，本发明提供了一种用于早期诊断，预后和监测疾病进程以及用于治疗和接种细胞增殖性疾病的方法，所述方法包括： 肺肿瘤。

    Compounds and methods for detection of carcinomas and their precursor lesions
    8.
    发明申请
    Compounds and methods for detection of carcinomas and their precursor lesions 审中-公开
    用于检测癌及其前体病变的化合物和方法

    公开(公告)号：US20060121485A1

    公开(公告)日：2006-06-08

    申请号：US10539233

    申请日：2003-12-16

    申请人： Johannes Coy

    发明人： Johannes Coy

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/573 ,  A61K38/1709 ,  C12N9/22 ,  C12Q1/34 ,  G01N33/57484 ,  G01N2333/922

    摘要： The present invention relates to compounds and methods for detection and treatment of carcinomas and their precursor lesions. The invention provides DNase nucleic acids and polypeptides useful for the detection and treatment of carcinomas and their precursor lesions. The invention is more specifically related to a method for detection of carcinomas and their precursor lesions comprising the detection of the level and/or the subcellular localization of one or more DNase molecules in biological samples. Furthermore the present invention provides methods for early diagnosis, prognosis and monitoring of the disease course of carcinomas and their precursor lesions as well as for the treatment of said lesions.

    摘要翻译： 本发明涉及用于检测和治疗癌及其前体病变的化合物和方法。 本发明提供了可用于检测和治疗癌症及其前体病变的DNA酶核酸和多肽。 本发明更具体地涉及用于检测癌及其前体病变的方法，其包括检测生物样品中一种或多种DNA酶分子的水平和/或亚细胞定位。 此外，本发明提供了用于早期诊断，预后和监测癌及其前体病变的疾病过程以及用于治疗所述病变的方法。

    Refreshing beverage
    10.
    发明授权
    Refreshing beverage 有权

    公开(公告)号：US10143221B2

    公开(公告)日：2018-12-04

    申请号：US13978535

    申请日：2011-12-20

    申请人： Johannes Coy

    发明人： Johannes Coy

    IPC分类号： A23L2/52 ,  A23L2/60 ,  A23L2/68 ,  A61K31/191 ,  A61K31/7016 ,  A61K36/73 ,  A61K36/736 ,  A61K36/752

    摘要： The invention relates to a novel sweet-tasting refreshing beverage, which is free of phosphoric acid and instead contains at least 0.3% by weight/volume of gluconic acid, which is low in minerals, specifically contains less than 250 mg/liter of minerals, which is low in sugar, specifically contains at most 2.5% by weight/volume of sugar, wherein these sugars comprise at least 10% weight/weight galactose and in addition a proportion of isomaltulose and/or tagatose, and which has a glycemic index of at most 35 (GI