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1.发明授权公开(公告)号：US08364254B2
公开(公告)日：2013-01-29
申请号：US12361174
申请日：2009-01-28
申请人： Arnaud Jacquin , Elvir Causevic
发明人： Arnaud Jacquin , Elvir Causevic
IPC分类号： A61B5/00
CPC分类号： A61B5/0476 , A61B5/0484 , A61B5/16 , A61B5/4076 , A61B5/7203 , A61B5/7207 , A61B5/726 , A61B5/7264 , G06F19/00
摘要： A method and apparatus for providing objective assessment of the brain state of a subject using a field portable device. The method includes placing an electrode set coupled to a handheld base unit on the subject's head, acquiring electrical brain signals from the subject through the electrode set, processing the acquired electrical brain signals using a feature extraction algorithm, classifying the extracted features into brain states, computing brain abnormality indices reflecting the probability of correct classification of brain state, and graphically displaying the classification result and the abnormality indices on the handheld base unit.
摘要翻译： 一种使用现场便携式设备提供对象的脑状态的客观评估的方法和装置。 该方法包括将耦合到手持基座单元的电极组放置在对象的头部上，通过电极组获取来自对象的电脑信号，使用特征提取算法处理所获取的电脑信号，将所提取的特征分类为脑状态， 计算反映大脑状态正确分类概率的脑异常指标，并在手持式基站上图形显示分类结果和异常指数。
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2.发明申请公开(公告)号：US20100191139A1
公开(公告)日：2010-07-29
申请号：US12361174
申请日：2009-01-28
申请人： Arnaud Jacquin , Elvir Causevic
发明人： Arnaud Jacquin , Elvir Causevic
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/0484 , A61B5/16 , A61B5/4076 , A61B5/7203 , A61B5/7207 , A61B5/726 , A61B5/7264 , G06F19/00
摘要： A method and apparatus for providing objective assessment of the brain state of a subject using a field portable device. The method includes placing an electrode set coupled to a handheld base unit on the subject's head, acquiring electrical brain signals from the subject through the electrode set, processing the acquired electrical brain signals using a feature extraction algorithm, classifying the extracted features into brain states, computing brain abnormality indices reflecting the probability of correct classification of brain state, and graphically displaying the classification result and the abnormality indices on the handheld base unit.
摘要翻译： 一种使用现场便携式设备提供对象的脑状态的客观评估的方法和装置。 该方法包括将耦合到手持基座单元的电极组放置在对象的头部上，通过电极组获取来自对象的电脑信号，使用特征提取算法处理所获取的电脑信号，将所提取的特征分类为脑状态， 计算反映大脑状态正确分类概率的脑异常指标，并在手持式基站上图形显示分类结果和异常指数。
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公开(公告)号：US20180165605A1
公开(公告)日：2018-06-14
申请号：US15837652
申请日：2017-12-11
申请人： Matthew Beers , Elvir Causevic
发明人： Matthew Beers , Elvir Causevic
CPC分类号： G06N20/00 , G06K9/00442 , G06K9/6227 , G06K9/626 , G06K9/6262 , G06K9/6277 , G06N3/0454 , G06N3/086 , G06N5/043
摘要： A machine-learning based artificial intelligence device for finding an estimate of patent quality, such as patent lifetime or term is disclosed. Such a device may receive a first set of patent data and generate a list of binary classifiers. A candidate set of binary classifiers may be selected and using a heuristic search, for example an artificial neural network (ANN), a genetic algorithm, a final set of binary classifiers is found by maximizing iteratively a yield according to a cost function, such an area under a curve (AUC) of a receiver operating characteristic (ROC). The device may then receive patent information for a target patent and report an estimate of patent quality according to the final set of binary classifiers.
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4.发明授权Fast wavelet estimation of weak bio-signals using novel algorithms for generating multiple additional data frames 有权使用用于生成多个附加数据帧的新算法对弱生物信号进行快速小波估计公开(公告)号：US07333619B2
公开(公告)日：2008-02-19
申请号：US11420862
申请日：2006-05-30
CPC分类号： G06K9/00516 , A61B5/04845 , A61B5/121 , A61B5/7203 , A61B5/726 , G10L21/0208 , G10L25/27 , H03G3/007
摘要： A method and apparatus for de-noising weak bio-signals having a relatively low signal to noise ratio utilizes an iterative process of wavelet de-noising a data set comprised of a new set of frames of wavelet coefficients partially generated through a cyclic shift algorithm. The method preferably operates on a data set having 2N frames, and the iteration is performed N−1 times. The resultant wavelet coefficients are then linearly averaged and an inverse discrete wavelet transform is performed to arrive at the de-noised original signal. The method is preferably carried out in a digital processor.
摘要翻译： 用于消除具有相对低的信噪比的弱生物信号的方法和装置利用小波去噪的迭代过程，该数据集包括通过循环移位算法部分产生的新的一组小波系数。 该方法优选地对具有2个N帧的数据集进行操作，并且迭代被执行N-1次。 然后对所得到的小波系数进行线性平均，并执行逆离散小波变换以得到去噪的原始信号。 该方法优选在数字处理器中进行。
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公开(公告)号：US20070167857A1
公开(公告)日：2007-07-19
申请号：US10587461
申请日：2005-01-28
申请人： Elvir Causevic
发明人： Elvir Causevic
CPC分类号： A61B5/125 , A61B5/0048 , A61B5/04842 , A61B5/04845 , A61B5/742
摘要： A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.
摘要翻译： 一种用于利用编码信号传输和接收的益处来增强适于唤起和测量例如听觉诱发电位（AEP）和听觉脑干响应（ABR）的生物反应信号的医学测试装置（100）的性能的方法和装置， 信号特别。 诸如点击的听觉刺激以预定编码序列呈现给人类患者的耳朵，导致在人类患者中产生听觉反应和生物电响应信号。 获取并观察来自患者的这些响应信号，并且根据将听觉刺激呈现给患者耳朵的预定编码序列进行处理，以便提取期望的听觉诱发电位信号或ABR信号。
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公开(公告)号：US20070167691A1
公开(公告)日：2007-07-19
申请号：US10587476
申请日：2005-01-28
申请人： Elvir Causevic
发明人： Elvir Causevic
CPC分类号： A61B5/14546 , A61B5/0002 , A61B5/04 , A61B5/04845 , A61B5/0836 , A61B5/7275 , A61B5/7445
摘要： A medical screening device (100) configured to measure and monitor combinations of blood chemistry, breath gasses, and bioelectrical signals such as evoked auditory signals and EEG signals associated with human auditory testing to facilitate detection of abnormal medical conditions or disorders in human patients by providing a cumulative index representative of at least one detected medical disorder in the human patient.
摘要翻译： 一种医疗筛选装置（100），其被配置为测量和监测血液化学，呼吸气体和生物电信号的组合，例如与人类听觉测试相关的诱发听觉信号和脑电信号，以便于通过提供人类病人的异常医学状况或障碍来检测 代表人类患者中至少一种检测到的医学病症的累积指数。
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公开(公告)号：US08734361B2
公开(公告)日：2014-05-27
申请号：US13180339
申请日：2011-07-11
申请人： Elvir Causevic
发明人： Elvir Causevic
CPC分类号： A61B5/125 , A61B5/0048 , A61B5/04842 , A61B5/04845 , A61B5/742
摘要： A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.
摘要翻译： 一种用于利用编码信号传输和接收的益处来增强适于唤起和测量例如听觉诱发电位（AEP）和听觉脑干响应（ABR）的生物反应信号的医学测试装置（100）的性能的方法和装置， 信号特别。 诸如点击的听觉刺激以预定编码序列呈现给人类患者的耳朵，导致在人类患者中产生听觉反应和生物电响应信号。 获取并观察来自患者的这些响应信号，并且根据将听觉刺激呈现给患者耳朵的预定编码序列进行处理，以便提取期望的听觉诱发电位信号或ABR信号。
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8.发明授权公开(公告)号：US07904144B2
公开(公告)日：2011-03-08
申请号：US11195001
申请日：2005-08-02
申请人： Elvir Causevic , Arthur H. Combs
发明人： Elvir Causevic , Arthur H. Combs
IPC分类号： A61B5/00
CPC分类号： A61B5/048 , A61B5/0484 , A61B5/411 , A61B5/7203 , A61B5/7257 , A61B5/726 , A61B5/7264
摘要： A method and apparatus for performing rapid brain assessment may provide emergency triage to head trauma patients by analyzing a combination of spontaneous and evoked brain potentials. The spontaneous and evoked potentials are analyzed, and the results classified, to present a real-time assessment of a patient's brain, diagnosing any potential abnormalities therein.
摘要翻译： 用于进行快速脑评估的方法和装置可以通过分析自发和诱发脑电位的组合来向头部创伤患者提供紧急分类。 分析自发和诱发电位，并将结果归类，以呈现患者大脑的实时评估，诊断其中的任何潜在异常。
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公开(公告)号：US20100185115A1
公开(公告)日：2010-07-22
申请号：US12710603
申请日：2010-02-23
IPC分类号： A61B5/0484
CPC分类号： A61B5/0482 , A61B5/0484 , A61B5/04845 , A61B5/04847 , A61B5/6815 , A61B5/6838
摘要： Apparatus (10) for evoking and recording bio-potentials from a human subject and methods of use are described. The apparatus (10) includes a flexible member (18) with a layer of conductive material (12) disposed thereon for contacting a skin surface on the human subject. The dimensions and shape of the flexible member (18) are adapted for conforming contact between the conductive material (12) and the skin surface. A stimulus delivery element (28) is coupled to the flexible member (18) for delivering a sensory stimulus to the subject to evoke bio-potentials, which are detected and received through the layer of conductive material (12).
摘要翻译： 描述了用于从人类受试者唤起和记录生物潜力的装置（10）和使用方法。 该设备（10）包括柔性构件（18），其上设置有用于接触人体对象皮肤表面的导电材料层（12）。 柔性构件（18）的尺寸和形状适于使导电材料（12）与皮肤表面之间的接触一致。 刺激递送元件（28）耦合到柔性构件（18），用于将感觉刺激传递给受试者，以引起通过导电材料层（12）检测和接收的生物电位。
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公开(公告)号：US20090018427A1
公开(公告)日：2009-01-15
申请号：US12067525
申请日：2006-09-22
IPC分类号： A61B5/04
CPC分类号： A61B5/04845 , A61B5/0478 , A61B5/6803 , A61B5/6814 , A61B2562/164
摘要： A disposable electrode array 100, 200 including a flexible member 106, 206 in which a plurality of electrodes 102, 202 are disposed, having a shape adapted to contact the forehead skin surface on a human patient. A pair of ear loops 104, 204 coupled to the disposable electrode array 100, 200 secure the disposable electrode array 100, 200 about the patient's ears, with the flexible member 106, 206 disposed across the patient's bow, retaining the electrodes 102, 202 against the skin surface. Additional electrodes 102, 202 are disposed in proximity to the ear loops 104, 204 and are configured to contact the skin surface behind the patient's ears. An auditory stimulus delivery element 116, 216 is coupled with each of the ear loops 104, 204, and positioned to seat in proximity to the patient's ear canal for the delivery of auditory stimulus. Electrical conductors associated with the electrodes 102, 202 and the stimulus delivery elements 116, 216 are routed within the flexible member 106, 206 to a common external connection point 118, 218 for connection to an external system. The disposable electrode array 100, 200 may be configured for both evoking and measuring evoked bio-potentials in the human subject, or for measuring bio-potentials evoked using a separate stimulus delivery system.
摘要翻译： 包括柔性构件106,206的一次性电极阵列100,200，其中设置有多个电极102,202，其具有适于接触人类患者的前额皮肤表面的形状。 耦合到一次性电极阵列100,200的一对耳环104,204将患者耳朵周围的一次性电极阵列100,200固定在一起，使柔性构件106,206跨过病人的弓状物设置，保持电极102,202抵抗 皮肤表面。 附加电极102,202设置在耳环104,204附近，并被配置为接触患者耳朵后面的皮肤表面。 听觉刺激传递元件116,216与耳环104,204中的每一个耦合，并被定位成靠近患者的耳道以便传送听觉刺激。 与电极102,202和刺激递送元件116,216相关联的电导体在柔性构件106,206内被路由到共同的外部连接点118,218以连接到外部系统。 一次性电极阵列100,200可以被配置用于唤醒和测量人类受试者中的诱发生物电位，或者用于测量使用单独的刺激递送系统诱发的生物电位。
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