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公开(公告)号：US20060088829A1
公开(公告)日：2006-04-27
申请号：US10504120
申请日：2003-02-05
申请人： Arthur Brace , Agnes Eliares , Kimberly Ferguson , Cynthia Seidel-Dugan , Felipa Mapa , Donald Ruhrmund , Jianfeng Wu
发明人： Arthur Brace , Agnes Eliares , Kimberly Ferguson , Cynthia Seidel-Dugan , Felipa Mapa , Donald Ruhrmund , Jianfeng Wu
CPC分类号： G01N33/74 , G01N33/5041 , G01N2333/62 , G01N2333/72 , G01N2500/00
摘要： Human MINR genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of MINR, comprising screening for agents that modulate the activity of MINR are provided.
摘要翻译： 人MINR基因被鉴定为INR信号传导的调节因子，因此是与缺陷型INR信号传导相关的病症的治疗靶点。 提供了识别MINR调节剂的方法，包括筛选调节MINR活性的试剂。
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2.发明申请公开(公告)号：US20100183583A1
公开(公告)日：2010-07-22
申请号：US11993191
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68 , A01K67/00 , C12N5/02
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
摘要翻译： 人GALK1基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶点。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节GALK1活性的试剂。
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3.发明授权公开(公告)号：US08679763B2
公开(公告)日：2014-03-25
申请号：US11908114
申请日：2006-03-10
申请人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
发明人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
IPC分类号： G01N33/53 , G01N33/58 , G01N33/15 , G01N33/487 , G01N33/577
CPC分类号： G01N33/5041
摘要： Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要翻译： 人EEF2K基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶标。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节EEF2K活性的试剂。
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4.发明申请COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2 审中-公开SERPINE2调节胶原和丝氨酸肌酸激酶表达的组合物和方法公开(公告)号：US20100183620A1
公开(公告)日：2010-07-22
申请号：US12626534
申请日：2009-11-25
申请人： KAUMUDI BHAWE , Elizabeth Bosch , Kathleen Boyle , Arthur Brace , Anuk Das , Francis Farrell , Pitchumani Sivakumar , Jeffrey Finer , Kristen Pierce , Kathleen M. Sullivan , Brian Wong
发明人： KAUMUDI BHAWE , Elizabeth Bosch , Kathleen Boyle , Arthur Brace , Anuk Das , Francis Farrell , Pitchumani Sivakumar , Jeffrey Finer , Kristen Pierce , Kathleen M. Sullivan , Brian Wong
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , A61K38/16 , A61P21/00 , C12Q1/68
CPC分类号： C07K14/811 , A61K38/57 , C07K16/38 , C07K2317/76
摘要： The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 本发明包括使用SERPINE2和SERPINE2拮抗剂增加或减少肺成纤维细胞中胶原1A1表达和/或α-平滑肌肌动蛋白表达的方法和组合物。 本发明还包括用于增加或减少肌成纤维细胞形成的方法和组合物。 本发明进一步提供了治疗肺部疾病如特发性肺纤维化和慢性阻塞性肺疾病的方法和组合物。
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5.发明申请公开(公告)号：US20100122354A1
公开(公告)日：2010-05-13
申请号：US11993122
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
摘要翻译： 人CDC6基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶点。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节CDC6活性的试剂。
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6.发明申请公开(公告)号：US20110135629A1
公开(公告)日：2011-06-09
申请号：US11993130
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , A61K31/7088 , A61P35/00 , C12Q1/68 , C12N5/00 , C12Q1/48 , G01N33/53
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
摘要翻译： 人类MPTENAKT基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷性PTEN / AKT功能相关的病症的治疗靶点。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节MPTENAKT活性的试剂。
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7.发明申请公开(公告)号：US20080193438A1
公开(公告)日：2008-08-14
申请号：US11908114
申请日：2006-03-10
申请人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
发明人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
IPC分类号： A61K39/395 , G01N33/53 , A61P35/00 , C12N5/00
CPC分类号： G01N33/5041
摘要： Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要翻译： 人EEF2K基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶标。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节EEF2K活性的试剂。
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