摘要:
Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
摘要:
Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
摘要:
Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
摘要:
Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要:
Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要:
The present invention relates to novel 3-(cyclohexano-heteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.
摘要:
Systems and methods for producing a carbonaceous paste are provided. The systems and methods may include a paste control system that obtains an image of the carbonaceous paste and determines whether operational parameters associated with paste production require adjustment. One or more operational variables may be adjusted based on the obtained images to facilitate production of the carbonaceous paste.
摘要:
A radial saw blade is formed of a flat disc having peripheral edge including circular peripheral portions and recessed stepped peripheral portions. The peripheral edge includes spaced apart, radially inwardly extending notches. Each notch has a flat, plate-like insert brazed to an L-shaped seat in the notch facing the direction of rotation. Each insert has cutting edges formed on side edges of the inserts which extend axially from both sides of the disc and on a crown edge extending radially from the peripheral edge of the disc. The side and crown edges each have beveled surfaces extending away from the direction of rotation to define a relief angle. A first set of the notches are positioned about the circular peripheral portion of the peripheral edge. The inserts in the first set of notches make the primary cut in both linear and non-linear passes. A second set of notches are circumferentially spaced along the recessed peripheral portions, or stepped portions, of the blade and are located at different radial distances from the center of the disc. The side cutting edges of the inserts in the second set of notches radially overlap the side cutting edges of radially adjacent cutting inserts in the second set of notches. The inserts in the second set of notches plane the raw cut edges cut by the first set of inserts on straight cuts. The inserts in the second set of notches also cut in the axial direction relative to the disc for curved and diagonal cutting to prevent the blade from binding in the kerf by providing axial relief.
摘要:
The present invention relates to certain 3-(4,5,6,7-tetrahydroindol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular Src kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.