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公开(公告)号：US20050113435A1
公开(公告)日：2005-05-26
申请号：US10959799
申请日：2004-10-06
申请人： Arthur Hancock , Eugene Bush , Marlon Cowart , Peer Jacobson , Terry Opgenorth , Youssef Bennani
发明人： Arthur Hancock , Eugene Bush , Marlon Cowart , Peer Jacobson , Terry Opgenorth , Youssef Bennani
IPC分类号： A61K31/00 , A61K31/165 , A61K31/353 , A61K31/382 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P3/00 , A61P3/10 , A61K31/366
CPC分类号： A61K31/40 , A61K31/00 , A61K31/165 , A61K31/353 , A61K31/382 , A61K31/397 , A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： The invention relates to a method of treating a diabetic condition by administering a therapeutically effective amount of a histamine-3 receptor antagonist, including benzofuran and benzopyran derivatives of formula (I), aminoalkoxybiphenylcarboxamide compounds of formula (III), and aminoetherbiphenyl compounds of formula (IV) as described herein.
摘要翻译： 本发明涉及通过施用治疗有效量的组胺-3受体拮抗剂（包括式（I）的苯并呋喃和苯并吡喃衍生物），式（III）的氨基烷氧基联苯甲酰胺化合物和式（III）的氨基醚联苯化合物 IV）。
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2.发明申请Novel amines as histamine-3 receptor ligands and their therapeutic applications 有权新型胺作为组胺-3受体配体及其治疗应用公开(公告)号：US20050192277A1
公开(公告)日：2005-09-01
申请号：US11102415
申请日：2005-04-08
IPC分类号： C07D307/79 , C07D307/81 , C07D333/54 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/04 , C07D491/08 , C07D491/10 , C07D521/00 , A61K31/5377 , A61K31/4025 , A61K31/416 , A61K31/4245 , C07D413/14 , C07D45/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D307/79 , C07D307/81 , C07D333/54 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/04 , C07D491/08 , C07D491/10
摘要： Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.
摘要翻译： 式（I）化合物或其药学上可接受的盐或前药，其可用于调节哺乳动物中的组胺-3受体，并且其可用于治疗组胺-3受体配体改善的病症。
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公开(公告)号：US20050227953A1
公开(公告)日：2005-10-13
申请号：US11096382
申请日：2005-04-01
申请人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
发明人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
CPC分类号： C07J71/00
摘要： Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
摘要翻译： 氮杂环绕组胺胺受体配体，包含这些化合物的药物组合物和使用这些化合物和组合物的方法在本文中描述。
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公开(公告)号：US20080021081A1
公开(公告)日：2008-01-24
申请号：US11766987
申请日：2007-06-22
申请人： Huaqing Liu , Lawrence Black , Youssef Bennani , Marlon Cowart
发明人： Huaqing Liu , Lawrence Black , Youssef Bennani , Marlon Cowart
IPC分类号： A61K31/40 , A61K31/415 , A61K31/4164 , A61P25/00 , A61P25/08 , A61P35/00 , A61P37/00 , C07D207/06 , C07D239/00 , C07D401/02
CPC分类号： C07D207/06 , C07D401/10 , C07D403/10 , C07D417/10 , C07D495/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US20050245495A1
公开(公告)日：2005-11-03
申请号：US10819849
申请日：2004-04-07
申请人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
发明人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
CPC分类号： C07J71/0042
摘要： Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
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公开(公告)号：US20080113982A1
公开(公告)日：2008-05-15
申请号：US12014566
申请日：2008-01-15
申请人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
发明人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
IPC分类号： A61K31/5377 , A61K31/403 , A61K31/427 , A61P3/08 , A61P25/28 , A61P9/00
CPC分类号： C07J71/00
摘要： Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
摘要翻译： 氮杂环绕组胺胺受体配体，包含这些化合物的药物组合物和使用这些化合物和组合物的方法在本文中描述。
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公开(公告)号：US20060194798A1
公开(公告)日：2006-08-31
申请号：US11418699
申请日：2006-05-05
申请人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Padam Sharma , Youssef Bennani , Michael Curtis
发明人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Padam Sharma , Youssef Bennani , Michael Curtis
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/4709 , A61K31/427 , C07D417/02 , C07D403/02
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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8.发明申请Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof 失效表现出CRTH2受体拮抗作用的吲哚乙酸及其应用公开(公告)号：US20060100425A1
公开(公告)日：2006-05-11
申请号：US11230917
申请日：2005-09-21
IPC分类号： C07D417/04 , C07D413/04 , C07D403/04
CPC分类号： C07D413/14 , C07D209/46 , C07D403/04 , C07D405/14 , C07D417/04 , C07D417/14
摘要： The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
摘要翻译： 本发明涉及作为CRTH2受体拮抗剂的吲哚乙酸化合物。 本发明还涉及这些化合物用于抑制前列腺素D 2和其代谢物或某些血栓烷代谢物与CRTH2受体的结合以及治疗对这种抑制作用的病症的结合的用途。
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公开(公告)号：US20060003990A1
公开(公告)日：2006-01-05
申请号：US11170266
申请日：2005-06-29
申请人： Youssef Bennani , Bayard Huck , Michael Robarge , David Bom , Norbert Varga , Lawrence Tumey
发明人： Youssef Bennani , Bayard Huck , Michael Robarge , David Bom , Norbert Varga , Lawrence Tumey
IPC分类号： A61K31/55 , C07D487/02
CPC分类号： C07D495/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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10.发明授权公开(公告)号：US08163732B2
公开(公告)日：2012-04-24
申请号：US12434154
申请日：2009-05-01
IPC分类号： A61K31/55 , C07D471/12
CPC分类号： C07D471/16 , C07D471/22 , C07D487/16
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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