Single analyte molecule detection by fibre fluorescence probe
    3.
    发明授权
    Single analyte molecule detection by fibre fluorescence probe 失效
    通过纤维荧光探针检测单分析物

    公开(公告)号:US07657133B2

    公开(公告)日:2010-02-02

    申请号:US11573800

    申请日:2005-08-18

    IPC分类号: G02B6/00

    摘要: An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.

    摘要翻译: 用于单一分析物分子检测的装置包括:用于产生激发光的光源(20); 分色镜(22),设置在由所述光源产生的激发光的第一路径上,其中所述反射镜将激发光引导到光纤对准器(30)中; 由光纤对准器耦合到光源的光学传感器,所述光学换能器包括由具有第一介电折射率的介电材料制成的光波导(40); 设置为接收荧光反射辐射的光子检测器(70),其中当提供具有低于第一指数的第二介电指数的测试溶液并且包括一个或多个靶分子时,激发光由波导传输并离开波导尖端 放置在测试溶液中以激发一个或多个靶分子; 随后,波导将沿着第二路径的反射辐射传输到检测传输的反射辐射的光子检测器。

    Storage device for a liquid medium
    6.
    发明授权
    Storage device for a liquid medium 失效
    液体介质储存装置

    公开(公告)号:US06923223B2

    公开(公告)日:2005-08-02

    申请号:US10626408

    申请日:2003-07-24

    IPC分类号: F15B1/10 B67C3/02

    摘要: A storage device for a liquid medium has a housing having an interior provided with at least one partitioning element dividing the interior into a first chamber for receiving the liquid medium and into a second chamber filled at least partially with a gas under pressure. The gas keeps the liquid medium in the first chamber under pressure. The at least one partitioning element is formed at least partially of an expandable bellows fastened pressure-tightly to a lid of the housing.

    摘要翻译: 用于液体介质的存储装置具有壳体,其具有设置有至少一个分隔件的内部,该至少一个分隔件将内部分成用于接收液体介质的第一室,并且至少部分地填充有压力气体的第二室。 气体在第一室内保持液体介质的压力。 所述至少一个分隔元件至少部分地由紧固地连接到壳体的盖的可膨胀波纹管形成。

    RAPID COMPETITIVE LEARNING TECHNIQUES FOR NEURAL NETWORKS

    公开(公告)号:US20180174054A1

    公开(公告)日:2018-06-21

    申请号:US15385378

    申请日:2016-12-20

    IPC分类号: G06N3/08 G06N3/04

    CPC分类号: G06N3/088 G06N3/006 G06N3/049

    摘要: Various systems and methods for implementing unsupervised or reinforcement learning operations for a neuron weight used in a neural network are described. In an example, the learning operations include processing a spike train input at a neuron of a spiking neural network, applying a synaptic weight, and observing spike events occurring before and after the neuron processing based on respective spike traces. A synaptic weight update process operates to generate a new value of the synaptic weight based upon the spike traces, configuration values, and a reference weight value. A reference weight update process also operates to generate a new value of the reference value for significant changes to the synaptic weight. Reinforcement may be provided in some examples to implement changes to the reference weight in reduced time. In some examples, the techniques may be implemented in a neuromorphic hardware implementation of the spiking neural network.

    Method of forming an inverted T shaped channel structure for an inverted T channel field effect transistor device
    8.
    发明授权
    Method of forming an inverted T shaped channel structure for an inverted T channel field effect transistor device 有权
    形成用于反向T沟道场效应晶体管器件的反相T形沟道结构的方法

    公开(公告)号:US08552501B2

    公开(公告)日:2013-10-08

    申请号:US13447369

    申请日:2012-04-16

    摘要: A method of forming an inverted T shaped channel structure having a vertical channel portion and a horizontal channel portion for an Inverted T channel Field Effect Transistor ITFET device comprises semiconductor substrate, a first layer of a first semiconductor material over the semiconductor substrate and a second layer of a second semiconductor material over the first layer. The first and the second semiconductor materials are selected such that the first semiconductor material has a rate of removal which is less than a rate of removal of the second semiconductor material.

    摘要翻译: 形成具有用于反向T沟道场效应晶体管ITFET器件的垂直沟道部分和水平沟道部分的反向T形沟道结构的方法包括半导体衬底,半导体衬底上的第一半导体材料的第一层和第二层 在第一层上的第二半导体材料。 选择第一和第二半导体材料,使得第一半导体材料具有小于除去第二半导体材料的速率的去除速率。

    Single Analyte Molecule Detection by Fibre Fluorescemce Probe
    9.
    发明申请
    Single Analyte Molecule Detection by Fibre Fluorescemce Probe 失效
    纤维荧光探针单分析物分子检测

    公开(公告)号:US20080089635A1

    公开(公告)日:2008-04-17

    申请号:US11573800

    申请日:2005-08-18

    IPC分类号: G02B6/04 G01N21/64

    摘要: An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.

    摘要翻译: 用于单一分析物分子检测的装置包括:用于产生激发光的光源(20); 分色镜(22),设置在由所述光源产生的激发光的第一路径上,其中所述反射镜将激发光引导到光纤对准器(30)中; 由光纤对准器耦合到光源的光学传感器,所述光学换能器包括由具有第一介电折射率的介电材料制成的光波导(40); 设置为接收荧光反射辐射的光子检测器(70),其中当提供具有低于第一指数的第二介电指数的测试溶液并且包括一个或多个靶分子时,激发光由波导传输并离开波导尖端 放置在测试溶液中以激发一个或多个靶分子; 随后,波导将沿着第二路径的反射辐射传输到检测传输的反射辐射的光子检测器。