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公开(公告)号：US08609715B2
公开(公告)日：2013-12-17
申请号：US13484822
申请日：2012-05-31
申请人： Atsushi Konishi , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
发明人： Atsushi Konishi , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
IPC分类号： A61K31/381 , C07D333/20
CPC分类号： A61K31/4535 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/426 , A61K31/4525 , C07C53/18 , C07D277/20 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/06 , C07F9/3808 , C07F9/65515
摘要： Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
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公开(公告)号：US20120283222A1
公开(公告)日：2012-11-08
申请号：US13484822
申请日：2012-05-31
申请人： Atsushi KONISHI , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
发明人： Atsushi KONISHI , Munetaka Tokumasu , Tamotsu Suzuki , Takahiro Koshiba , Koji Ohsumi , Osamu Ikehara , Yuko Kodama
IPC分类号： A61K31/341 , C07D405/06 , A61K31/4025 , C07D333/38 , A61K31/381 , C07D277/56 , A61K31/426 , A61K31/4525 , C07F9/655 , A61K31/665 , C07D409/06 , A61K31/4535 , C07F9/6553 , A61K31/67 , A61P3/10 , A61P3/08 , A61P3/04 , A61P3/06 , A61P3/00 , C07D307/68
CPC分类号： A61K31/4535 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/426 , A61K31/4525 , C07C53/18 , C07D277/20 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/06 , C07F9/3808 , C07F9/65515
摘要： Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
摘要翻译： 由式（I）表示的化合物：其中每个符号如说明书中所定义，及其药学上可接受的盐可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。
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公开(公告)号：US20130338132A1
公开(公告)日：2013-12-19
申请号：US13517805
申请日：2012-06-14
申请人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
发明人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
IPC分类号： A61K31/381 , C07D409/06 , A61K31/4025 , A61K31/4535 , C07D409/12 , A61P3/00 , A61K31/397 , A61K31/4725 , A61K31/396 , A61K31/41 , A61P3/10 , A61P3/06 , C07D333/38 , A61K31/4436
CPC分类号： A61K31/381 , A61K31/19 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4436 , A61K31/4535 , A61K31/4725 , A61K38/05 , C07D319/12 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12
摘要： Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
摘要翻译： 由下式（I）表示的化合物可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。
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公开(公告)号：US09024044B2
公开(公告)日：2015-05-05
申请号：US13517805
申请日：2012-06-14
申请人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
发明人： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
IPC分类号： C07D319/12
CPC分类号： A61K31/381 , A61K31/19 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4436 , A61K31/4535 , A61K31/4725 , A61K38/05 , C07D319/12 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12
摘要： Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
摘要翻译： 由下式（I）表示的化合物可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。
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公开(公告)号：US08309561B2
公开(公告)日：2012-11-13
申请号：US11963144
申请日：2007-12-21
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70 , C07D239/95
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译： 特定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号：US20050222141A1
公开(公告)日：2005-10-06
申请号：US11018226
申请日：2004-12-22
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D239/70 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/02 , C07D417/02 , C07D471/04 , C07D487/04 , C07D43/02
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译： 具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号：US20080108634A1
公开(公告)日：2008-05-08
申请号：US11963144
申请日：2007-12-21
申请人： Kazuyuki SAGI , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki SAGI , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61P29/00
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译： 具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号：US07345049B2
公开(公告)日：2008-03-18
申请号：US11018226
申请日：2004-12-22
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70 , C07D239/95
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译： 具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号：US07683077B2
公开(公告)日：2010-03-23
申请号：US10557353
申请日：2004-05-19
申请人： Shingo Makino , Naoyuki Fukuchi , Sayaka Asari , Masaki Hashimoto , Tetsuo Yano , Youji Yamada , Munetaka Tokumasu , Masataka Shoji , Itsuya Tanabe , Shinichi Fujita , Hideki Matsumoto
发明人： Shingo Makino , Naoyuki Fukuchi , Sayaka Asari , Masaki Hashimoto , Tetsuo Yano , Youji Yamada , Munetaka Tokumasu , Masataka Shoji , Itsuya Tanabe , Shinichi Fujita , Hideki Matsumoto
IPC分类号： A61K31/445 , C07D211/08 , C07D211/22 , C07D211/20
CPC分类号： C07D211/70
摘要： The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7.
摘要翻译： 本发明提供由下式表示的哌啶衍生物或其类似物，其用于治疗或预防与5-HT7相关的各种疾病的药剂。
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10.发明授权Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same 失效二氢二氧氮杂衍生物和含有它们的药物组合物公开(公告)号：US07320973B2
公开(公告)日：2008-01-22
申请号：US10724179
申请日：2003-12-01
申请人： Katsutoshi Sakata , Takashi Tsuji , Munetaka Tokumasu , Kazuyoshi Takahashi , Shigeo Hirasawa , Junko Ezaki
发明人： Katsutoshi Sakata , Takashi Tsuji , Munetaka Tokumasu , Kazuyoshi Takahashi , Shigeo Hirasawa , Junko Ezaki
IPC分类号： A61P1/00 , A61K31/553 , C07D267/18 , C07D413/00
CPC分类号： C07D267/20
摘要： The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts
摘要翻译： 本发明提供由下式[1]表示的二氢二氧氮杂衍生物，其类似物和含有它们的药物组合物。 这些化合物具有改善胃肠道功能性疾病的极好作用
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