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公开(公告)号：US20220074831A1
公开(公告)日：2022-03-10
申请号：US17424396
申请日：2020-01-23
发明人： Qihua Xu , Kristin Weidemaier , Jon E. Salomon , Alexander G. Lastovich , Eric A. Fallows , Sean Connell , Joshua Herr , Meghan Wolfgang , Michael A. Brasch , Richard L. Moore , David S. Sebba , Cristian Clavijo , Shirley Ng , Richard Abbott , Alexander Adam Papp , Henry Li-Wei Fu , Caitlin Marie Austin , Sean Patrick Dowling , Owen Lewis Joyce , Michael L. Kiplinger , William Kevin Carpenter
摘要： Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.
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2.发明申请公开(公告)号：US20180136204A1
公开(公告)日：2018-05-17
申请号：US15822879
申请日：2017-11-27
发明人： Kristin Weidemaier , Robert L. Campbell , Erin Gooch Carruthers , Adam Craig Curry , Kevin G. Dolan , Andrea Liebmann-Vinson , Wendy Dale Woodley , Melody M.H. Kuroda , Ammon David Lentz , Dwight Livingston , Michael Justin Lizzi , Artis R. Lockhart , Ernie Ritchey , Eric A. Fallows , Donald E. Gorelick , Jack Kessler , Spencer Lovette , Jeffrey S. Ojala , Mark A. Talmer , Miroslaw Bartkowiak , Scott N. Danhof , Gregory S. Kramer , Thomas D. Haubert , Michael L. Marshall , James A. Prescott , Randy J. Somerville , M. Scott Ulrich , David S. Sebba
IPC分类号： G01N33/543 , B01L3/02 , B01L3/00 , B03C1/01 , B03C1/28 , C12M1/24 , C12M1/00 , C12M1/26 , C12M1/34 , G01N33/569 , G01N35/00
CPC分类号： G01N33/54333 , B01L3/0217 , B01L3/502 , B01L3/50825 , B01L2200/026 , B01L2200/0605 , B01L2200/10 , B03C1/01 , B03C1/288 , B03C2201/26 , C12M23/08 , C12M23/22 , C12M23/38 , C12M33/04 , C12M41/14 , C12M41/36 , G01N33/56911 , G01N35/0098
摘要： Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
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公开(公告)号：US10962533B2
公开(公告)日：2021-03-30
申请号：US15822879
申请日：2017-11-27
发明人： Kristin Weidemaier , Erin Gooch Carruthers , Adam C. Curry , Melody M. H. Kuroda , Ammon David Lentz , Michael Justin Lizzi , Eric A. Fallows , Donald E. Gorelick , Jack Kessler , Spencer Lovette , Jeffrey S. Ojala , Mark A. Talmer
IPC分类号： G01N33/553 , G01N33/543 , C12M1/34 , G01N35/00 , B03C1/01 , B03C1/28 , G01N33/569 , C12M1/00 , C12M1/26 , C12M1/24 , B01L3/02 , B01L3/00
摘要： Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
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公开(公告)号：US20180059118A1
公开(公告)日：2018-03-01
申请号：US15712972
申请日：2017-09-22
发明人： Kristin Weidemaier , Christian Sandmann , William Shannon Dillmore , James L. Schram , W. William Stewart , Robert E. Pearson , Helen Hsieh , Steven Keith , Rajendra R. Bhat , Andrea Liebmann-Vinson , Adam Craig Curry , Alexander G. Lastovich
IPC分类号： G01N33/58 , G01N21/65 , G01N33/543
CPC分类号： G01N33/587 , G01N21/658 , G01N33/54333
摘要： Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.
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公开(公告)号：US20170252706A1
公开(公告)日：2017-09-07
申请号：US15447859
申请日：2017-03-02
发明人： Qihua Xu , Kristin Weidemaier , Christopher Basciano , Sivaramakrishnan Balasubramanian , Patrick Downie
CPC分类号： B01D71/50 , A61M1/16 , A61M1/34 , A61M2205/3331 , B01D29/0004 , B01D63/02 , B01D63/08 , B01D69/06 , G01N33/491
摘要： A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
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公开(公告)号：US11344851B2
公开(公告)日：2022-05-31
申请号：US16658350
申请日：2019-10-21
发明人： Qihua Xu , Kristin Weidemaier , Christopher Basciano , Sivaramakrishnan Balasubramanian , Patrick Downie
摘要： A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
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公开(公告)号：US11016095B2
公开(公告)日：2021-05-25
申请号：US15712972
申请日：2017-09-22
发明人： Kristin Weidemaier , Christian Sandmann , William Shannon Dillmore , James L. Schram , W. William Stewart , Robert E. Pearson , Helen Hsieh , Steven Keith , Rajendra R. Bhat , Andrea Liebmann-Vinson , Adam Craig Curry , Alexander G. Lastovich
IPC分类号： G01N33/58 , G01N21/65 , G01N33/543
摘要： Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.
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公开(公告)号：US09874555B2
公开(公告)日：2018-01-23
申请号：US14391340
申请日：2013-03-15
发明人： Kristin Weidemaier , Robert L. Campbell , Erin Gooch Carruthers , Adam C. Curry , Kevin G. Dolan , Andrea Liebmann-Vinson , Wendy Dale Woodley , Melody M. H. Kuroda , Eric A. Fallows , Miroslaw Bartkowiak , Scott N. Danhof , Gregory S. Kramer , Thomas D. Haubert , Michael L. Marshall , James A. Prescott , Randy J. Somerville , M. Scott Ulrich , David S. Sebba
IPC分类号： C12M1/34 , G01N33/543 , G01N33/569 , C12M1/00 , C12M1/26 , C12M1/24 , G01N35/00 , B03C1/01 , B03C1/28 , B01L3/02 , B01L3/00
CPC分类号： G01N33/54333 , B01L3/0217 , B01L3/502 , B01L3/50825 , B01L2200/026 , B01L2200/0605 , B01L2200/10 , B03C1/01 , B03C1/288 , B03C2201/26 , C12M23/08 , C12M23/22 , C12M23/38 , C12M33/04 , C12M41/14 , C12M41/36 , G01N33/56911 , G01N35/0098
摘要： Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
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公开(公告)号：US11305241B2
公开(公告)日：2022-04-19
申请号：US16658350
申请日：2019-10-21
发明人： Qihua Xu , Kristin Weidemaier , Christopher Basciano , Sivaramakrishnan Balasubramanian , Patrick Downie
摘要： A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
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公开(公告)号：US20210378567A1
公开(公告)日：2021-12-09
申请号：US17340788
申请日：2021-06-07
摘要： A blood separation device that allows high quality plasma to be generated using a single power source. The device includes a housing with an inlet port adapted to receive the blood sample, a first chamber having a first chamber flow channel in fluid communication with the inlet port, a second chamber having a second chamber flow channel, a separation member disposed between the first chamber and the second chamber. In some embodiments, the blood separation device detects or tests for the presence of a substance, such as an antigen or an antibody.
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