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公开(公告)号：US12259356B2
公开(公告)日：2025-03-25
申请号：US17544591
申请日：2021-12-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kenneth Oh , Carl Marlowe , Stephen L. Swihart , Evan Thrush , Michael Griffin
IPC: G01N27/447 , G01N21/64 , G01N33/58 , G01N33/68
Abstract: Methods and reference compositions for quantifying protein using tagged standards. In an exemplary method, a reference composition and a protein may be electrophoresed in respective lanes of a gel. The reference composition may include quantitation standards of different size and each including a tag present at a different concentration. The quantitation standards and the protein may be transferred from the gel to a solid support to create a blot. Luminescence may be detected from the blot to obtain respective luminescence values separately representing an abundance of the tag of each quantitation standard and an abundance of the protein. A quantity of the protein may be determined using the respective luminescence values.
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公开(公告)号：US20240334032A1
公开(公告)日：2024-10-03
申请号：US18629257
申请日：2024-04-08
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Stephen Swihart , Li Lu , Wade Jameson , Evan Thrush , Michael Griffin , Evelio Perez
CPC classification number: H04N23/52 , H04N23/55 , H05K7/20472
Abstract: An electronic component assembly having thermal pads with thermal vias coupling an image sensor and a camera board fab is provided for heat dissipation. The electronic component assembly can include: a circuit board having at least one thermal pad disposed on a top surface of the circuit board; and an image sensor disposed on the top surface of the circuit board, having at least one conductive pad disposed at at least one corner of the image sensor. The at least one thermal pad is coupled to the at least one conductive pad of the image sensor and the at least one thermal pad is formed with a plurality of first thermal vias penetrating the thermal pad and the circuit board for transfer of heat of the image sensor.
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公开(公告)号：US11553116B2
公开(公告)日：2023-01-10
申请号：US17108672
申请日：2020-12-01
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Stephen Swihart , Li Lu , Wade Jameson , Evan Thrush , Michael Griffin , Evelio Perez
Abstract: An electronic component assembly having thermal pads with thermal vias coupling an image sensor and a camera board fab is provided for heat dissipation. The electronic component assembly can include: a circuit board having at least one thermal pad disposed on a top surface of the circuit board; and an image sensor disposed on the top surface of the circuit board, having at least one conductive pad disposed at at least one corner of the image sensor. The at least one thermal pad is coupled to the at least one conductive pad of the image sensor and the at least one thermal pad is formed with a plurality of first thermal vias penetrating the thermal pad and the circuit board for transfer of heat of the image sensor.
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公开(公告)号：US12015751B2
公开(公告)日：2024-06-18
申请号：US18082330
申请日：2022-12-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Stephen Swihart , Evan Thrush , Carl Marlowe , Kenneth Oh , Michael Griffin
IPC: H04N1/10 , G06T5/50 , G06V10/141 , H04N1/028
CPC classification number: H04N1/1008 , G06T5/50 , G06V10/141 , H04N1/02865 , G06T2207/20221
Abstract: Systems and methods for contact imaging of stands with illumination are disclosed herein. A contact imaging system can include a contact imager. The contact imager can include a housing having a base and a lid. The lid can have a closed position against the base and an open position. The contact imager can include a contact area image sensor. The lid can shield the contact area image sensor from ambient light when the lid is in the closed position. The contact imager can include an illuminator that can illuminate at least a portion of a blot on the contact area image sensor when the lid is in the closed position.
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公开(公告)号：US11956522B2
公开(公告)日：2024-04-09
申请号：US18063946
申请日：2022-12-09
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Stephen Swihart , Li Lu , Wade Jameson , Evan Thrush , Michael Griffin , Evelio Perez
CPC classification number: H04N23/52 , H04N23/55 , H05K7/20472
Abstract: An electronic component assembly having thermal pads with thermal vias coupling an image sensor and a camera board fab is provided for heat dissipation. The electronic component assembly can include: a circuit board having at least one thermal pad disposed on a top surface of the circuit board; and an image sensor disposed on the top surface of the circuit board, having at least one conductive pad disposed at at least one corner of the image sensor. The at least one thermal pad is coupled to the at least one conductive pad of the image sensor and the at least one thermal pad is formed with a plurality of first thermal vias penetrating the thermal pad and the circuit board for transfer of heat of the image sensor.
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Patent Agency Ranking
公开(公告)号：US11212454B2
公开(公告)日：2021-12-28
申请号：US16597665
申请日：2019-10-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael Griffin , Stephen Swihart
IPC: H04N5/235
Abstract: A method of image capture helps avoid saturation in digital imaging. In one implementation, the method includes capturing a first digital image of a target using an electronic array light sensor, and identifying one or more saturated pixels in the first digital image. The method further includes identifying a region of interest in the first digital image, the region of interest encompassing the one or more identified saturated pixels. The method also includes capturing a second digital image of the target using the electronic array light sensor. The second digital image encompasses only the region of interest, and the second digital image is captured with a shorter exposure time than the first digital image. The first and second digital images may be combined into a high dynamic range image. Systems for digital imaging may be based on complementary metal oxide semiconductor (CMOS) or charge coupled device (CCD) sensors.
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公开(公告)号：US20210176386A1
公开(公告)日：2021-06-10
申请号：US17108672
申请日：2020-12-01
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Stephen Swihart , Li Lu , Wade Jameson , Evan Thrush , Michael Griffin , Evelio Perez
Abstract: An electronic component assembly having thermal pads with thermal vias coupling an image sensor and a camera board fab is provided for heat dissipation. The electronic component assembly can include: a circuit board having at least one thermal pad disposed on a top surface of the circuit board; and an image sensor disposed on the top surface of the circuit board, having at least one conductive pad disposed at at least one corner of the image sensor. The at least one thermal pad is coupled to the at least one conductive pad of the image sensor and the at least one thermal pad is formed with a plurality of first thermal vias penetrating the thermal pad and the circuit board for transfer of heat of the image sensor.
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公开(公告)号：US20180182100A1
公开(公告)日：2018-06-28
申请号：US15850405
申请日：2017-12-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Clayton T. McKee , Michael Griffin
CPC classification number: G06T7/0014 , G01N21/5911 , G01N21/6456 , G01N21/76 , G01N27/447 , G01N27/44721 , G01N33/54393 , G01N33/582 , G06T5/001 , G06T5/30 , G06T5/50 , G06T7/155 , G06T7/194 , G06T2207/10056 , G06T2207/10064 , G06T2207/20036 , G06T2207/20224 , G06T2207/30024
Abstract: Systems and methods for producing blot images. A blot, for example a western blot, is imaged using an imaging system having a field of view and a magnification. Features of interest in the blot correspond to features in the digital image, and the sizes of the features in the digital image depend on the magnification of the imaging system. A structuring element is selected based on the sizes and shapes of the features in the digital image, and the image is morphologically eroded and dilated varying numbers of times. The eroded and dilated image is subtracted from the original blot image to remove background signal from the blot image, producing an output image. The number of erosions needed to completely erode the features of interest is determined automatically, for example by investigating the behavior of the kurtosis of the output image as a function of the number of erosions performed.
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公开(公告)号：US09971138B2
公开(公告)日：2018-05-15
申请号：US14262559
申请日：2014-04-25
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael Griffin , Daniel Yue Man Chu , Tom McCollum
CPC classification number: G02B21/06 , G02B21/125 , G02B21/16 , G02B21/24 , G02B21/365
Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
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公开(公告)号：US20140293412A1
公开(公告)日：2014-10-02
申请号：US14262559
申请日：2014-04-25
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael Griffin , Daniel Yue Man Chu , Tom McCollum
IPC: G02B21/06
CPC classification number: G02B21/06 , G02B21/125 , G02B21/16 , G02B21/24 , G02B21/365
Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
Abstract translation: 公开了一种使用模块显微镜的系统，装置和方法。 连接各个显微镜模块的外壳提供了模块化显微镜的结构框架。 此外，模块化显微镜可以包括专门的软件，可以使用存储在一个或多个显微镜模块上的安全密钥或标识符来控制其分布和使用。 安全密钥和标识符可以基于与多个模块之一的物理，电或光学特性相关联的校准数据。 所公开的照明模块为亮场和暗场照明提供了可选择的波长和输出照明的可控电平。
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