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1.发明授权Temporal release of growth factors from 3D micro rod scaffolds for tissue regeneration 失效来自3D微棒支架的组织再生的生长因子的时间释放公开(公告)号：US08591933B2
公开(公告)日：2013-11-26
申请号：US12689906
申请日：2010-01-19
申请人： Brenda Russell , Tejal A. Desai , Paul Goldspink
发明人： Brenda Russell , Tejal A. Desai , Paul Goldspink
CPC分类号： A61K9/0019
摘要： The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders.
摘要翻译： 本发明涉及三维微支架用于临床释放可用于组织再生，工程和治疗疾病的生长因子的用途。
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2.发明申请TEMPORAL RELEASE OF GROWTH FACTORS FROM 3D MICRO ROD SCAFFOLDS FOR TISSUE REGENERATION 失效用于组织再生的三维微阵列的生长因子的时间序列释放公开(公告)号：US20100158979A1
公开(公告)日：2010-06-24
申请号：US12689906
申请日：2010-01-19
申请人： BRENDA RUSSELL , Tejal A. Desai , Paul Goldspink
发明人： BRENDA RUSSELL , Tejal A. Desai , Paul Goldspink
CPC分类号： A61K9/0019
摘要： The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders.
摘要翻译： 本发明涉及三维微支架用于临床释放可用于组织再生，工程和治疗疾病的生长因子的用途。
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3.发明授权公开(公告)号：US06942873B2
公开(公告)日：2005-09-13
申请号：US09961834
申请日：2001-09-24
申请人： Brenda Russell , Tejal A. Desai , Luke Hanley
发明人： Brenda Russell , Tejal A. Desai , Luke Hanley
CPC分类号： C12N5/0657 , A61K35/12 , C12N5/0068 , C12N2503/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： The present invention provides a novel substrate for use in growing cells and for the study of mechanobiology. The membrane of the present invention comprises appropriate microtopography and surface chemical modifications to facilitate the production of adherent and oriented cells that phenotypically resemble cells in vivo.
摘要翻译： 本发明提供了用于生长细胞和用于机械生物学研究的新型底物。 本发明的膜包括适当的微观形态学和表面化学修饰，以促进在体内与细胞表型相似的贴壁和定向细胞的产生。
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4.发明授权Method of growing stem cells on a membrane containing projections and grooves 失效在含有突起和凹槽的膜上生长干细胞的方法公开(公告)号：US07695967B1
公开(公告)日：2010-04-13
申请号：US11062374
申请日：2005-02-22
申请人： Brenda Russell , Tejal A. Desai
发明人： Brenda Russell , Tejal A. Desai
CPC分类号： C12N5/0657 , A61K35/12 , C12N5/0068 , C12N2503/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： The present invention provides a novel substrate for use in growing cells and for the study of mechanobiology. The membrane of the present invention comprises appropriate microtopography and surface chemical modifications to facilitate the production of adherent and oriented cells that phenotypically resemble cells in vivo.
摘要翻译： 本发明提供了用于生长细胞和用于机械生物学研究的新型底物。 本发明的膜包括适当的微观形态学和表面化学修饰，以促进在体内与细胞表型相似的贴壁和定向细胞的产生。
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5.发明申请公开(公告)号：US20120114734A1
公开(公告)日：2012-05-10
申请号：US12530015
申请日：2008-03-17
申请人： Tejal A. Desai , Ketal C. Popat , Craig A. Grimes
发明人： Tejal A. Desai , Ketal C. Popat , Craig A. Grimes
IPC分类号： A61K38/18 , A61K39/395 , A61K31/713 , A61K9/00 , A61K31/56 , A61K31/711 , B82Y5/00
CPC分类号： A61L27/54 , A61C8/0012 , A61F2/0077 , A61F2/30767 , A61F2002/30064 , A61F2002/3084 , A61F2310/00401 , A61F2310/00407 , A61F2310/00413 , A61F2310/00437 , A61F2310/00461 , A61F2310/00544 , A61F2310/00598 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0097 , A61F2310/00976 , A61F2310/00988 , A61L2300/222 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/602 , A61L2400/12
摘要： Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.
摘要翻译： 包括包含纳米纤维，纳米管或微孔的表面或膜的组合物包括用于在将组合物置于受试者中时向周围组织洗脱的生物活性剂的组合物可用于医疗植入物和治疗需要植入物的患者的方法 包括矫形植入物，牙种植体，心血管植入物，神经植入物，神经血管植入物，胃肠道植入物，肌肉植入物和眼睛植入物。
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6.发明申请Multilayer Thin Film Drug Delivery Device and Methods of Making and Using the Same 审中-公开多层薄膜药物输送装置及其使用方法公开(公告)号：US20140170204A1
公开(公告)日：2014-06-19
申请号：US14110549
申请日：2012-04-12
CPC分类号： A61K9/0048 , A61F9/0017 , A61K9/0051 , A61K9/2086 , A61K9/7007 , A61K31/436 , A61K47/34 , A61K47/42 , B82Y30/00 , B82Y40/00 , C08J5/18 , C08J2300/16 , C08J2367/04 , C08J2489/06
摘要： Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.
摘要翻译： 提供了包括用于在给予受试者时向周围组织洗脱的生物活性剂的多层薄膜装置。 多层薄膜器件可用作医疗器件，例如眼睛器件。 还提供了用于将生物活性剂局部递送到受试者的组织的方法和试剂盒以及制备本发明装置的方法。 多层薄膜医疗装置包括第一层，生物活性剂和第二层。 第一层和第二层可以是多孔的或非多孔的。 这些装置具有褶皱结构，适于对受试者施用。
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7.发明申请TOPOGRAPHICALLY ENGINEERED STRUCTURES AND METHODS FOR USING THE SAME IN REGENERATIVE MEDICINE APPLICATIONS 审中-公开地理工程结构及其在再生医学应用中的应用方法公开(公告)号：US20100318193A1
公开(公告)日：2010-12-16
申请号：US12530013
申请日：2008-03-10
申请人： Tejal A. Desai , Sarah Tao , Michael Young , Henry J. Klassen
发明人： Tejal A. Desai , Sarah Tao , Michael Young , Henry J. Klassen
IPC分类号： A61F2/02
CPC分类号： A61L27/04 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/602 , A61L2400/12 , C08L33/12 , C08L67/04
摘要： The present invention provides compositions including a cell contacting surface or film comprising nanotopography of nanofibers, nanotubes, nanochannels, microchannels or microwells, which are capable of enhancing or promoting cell differentiation or cell viability. The compositions are useful as medical implants, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants. The present invention also provides methods of treating a patient in need of such an implant.
摘要翻译： 本发明提供包含能够增强或促进细胞分化或细胞活力的纳米纤维，纳米管，纳米通道，微通道或微孔的纳米形貌的细胞接触表面或膜的组合物。 组合物可用作医疗植入物，包括矫形植入物，牙种植体，心血管植入物，神经植入物，神经血管植入物，胃肠道植入物，肌肉植入物和眼睛植入物。 本发明还提供了治疗需要这种植入物的患者的方法。
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公开(公告)号：US06405066B1
公开(公告)日：2002-06-11
申请号：US09528277
申请日：2000-03-17
IPC分类号： A61B505
CPC分类号： A61B5/14865 , C12Q1/006
摘要： An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.
摘要翻译： 可植入分析物传感器包括基底，基底上的电极和电极上的膜。 膜可以包含元素硅，并且在330分钟内具有至少1mg / dl的葡萄糖扩散测试结果，并且在420分钟内白蛋白扩散测试结果为至多0.1g / dl。
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公开(公告)号：US09775932B2
公开(公告)日：2017-10-03
申请号：US12530015
申请日：2008-03-17
申请人： Tejal A. Desai , Ketal C. Popat , Craig A. Grimes
发明人： Tejal A. Desai , Ketal C. Popat , Craig A. Grimes
CPC分类号： A61L27/54 , A61C8/0012 , A61F2/0077 , A61F2/30767 , A61F2002/30064 , A61F2002/3084 , A61F2310/00401 , A61F2310/00407 , A61F2310/00413 , A61F2310/00437 , A61F2310/00461 , A61F2310/00544 , A61F2310/00598 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0097 , A61F2310/00976 , A61F2310/00988 , A61L2300/222 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/602 , A61L2400/12
摘要： Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.
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