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公开(公告)号:US08629250B2
公开(公告)日:2014-01-14
申请号:US12022515
申请日:2008-01-30
申请人: Barbra Sasu , Mitsuru Haniu , Thomas Charles Boone , Xiao-juan Bi , Grace Ki Jeong Lee , Tara Arvedson , Aaron George Winters , Keegan Cooke , Jackie Z. Sheng
发明人: Barbra Sasu , Mitsuru Haniu , Thomas Charles Boone , Xiao-juan Bi , Grace Ki Jeong Lee , Tara Arvedson , Aaron George Winters , Keegan Cooke , Jackie Z. Sheng
IPC分类号: C07K16/00 , A61K39/395 , C07K16/28
CPC分类号: C07K16/26 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K14/575 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N15/1136 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N33/74 , A61K2300/00
摘要: The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.
摘要翻译: 本发明涉及纯化的,正确折叠的铁调素,结合铁调素的抗体,以及制备和使用这些材料的方法。 还提供了治疗的铁调素相关病症的方法。
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公开(公告)号:US20120269814A1
公开(公告)日:2012-10-25
申请号:US13508973
申请日:2010-11-10
申请人: Ping Wei , Aaron George Winters , Christina Abbott
发明人: Ping Wei , Aaron George Winters , Christina Abbott
IPC分类号: C07K16/30 , C12N15/13 , G01N33/577 , C12N5/16 , C12P21/02 , G01N33/574 , A61K39/395 , C12N15/85
CPC分类号: C07K16/2866 , C07K2317/76 , C07K2317/92 , C12N15/1135 , C12N2310/14
摘要: The present invention provides compositions and methods utilizing antagonistic antibodies which specifically bind to human c-MPL (e.g., TPO-R).
摘要翻译: 本发明提供了使用与人c-MPL(例如TPO-R)特异性结合的拮抗性抗体的组合物和方法。
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公开(公告)号:US08003108B2
公开(公告)日:2011-08-23
申请号:US11410540
申请日:2006-04-25
申请人: Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
发明人: Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
CPC分类号: C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译: 提供了与硬骨素蛋白表位有关的组合物和方法,以及硬骨素结合剂,例如能结合硬化蛋白的抗体。
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公开(公告)号:US20120288507A1
公开(公告)日:2012-11-15
申请号:US13516161
申请日:2010-12-17
IPC分类号: C07K16/18 , A61P13/12 , C07K19/00 , A61K39/395 , C07K14/47
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要: The present invention relates to binding agents for WISE, and includes methods for their manufacture and use.
摘要翻译: 本发明涉及WISE的粘合剂,并且包括其制造和使用的方法。
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公开(公告)号:US08043620B2
公开(公告)日:2011-10-25
申请号:US12275850
申请日:2008-11-21
申请人: Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人: Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号: A61K39/395 , C07K16/22 , C07K16/46
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译: 本发明涉及用于WISE的粘合剂,并且包括其制造和使用。
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公开(公告)号:US08309092B2
公开(公告)日:2012-11-13
申请号:US13233983
申请日:2011-09-15
申请人: Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人: Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号: A61K39/395 , C07K16/22 , C07K16/46
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译: 本发明涉及用于WISE的粘合剂,并且包括其制造和使用。
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公开(公告)号:US20090130114A1
公开(公告)日:2009-05-21
申请号:US12275850
申请日:2008-11-21
申请人: Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人: Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号: A61K39/395 , C07K16/18 , C07K14/47 , A61P43/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译: 本发明涉及用于WISE的粘合剂,并且包括其制造和使用。
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公开(公告)号:US20120003237A1
公开(公告)日:2012-01-05
申请号:US13233983
申请日:2011-09-15
申请人: Xueming QIAN , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人: Xueming QIAN , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号: A61K39/395 , C07K17/08 , A61P13/00 , A61P11/00 , A61P13/12 , A61P29/00 , C07K16/18 , C07K19/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译: 本发明涉及用于WISE的粘合剂,并且包括其制造和使用。
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公开(公告)号:US20090304713A1
公开(公告)日:2009-12-10
申请号:US12276889
申请日:2008-11-24
申请人: Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
发明人: Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
IPC分类号: A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K7/06 , C07K7/08 , C07K19/00 , C07K14/76 , C07K14/79
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译: 提供了与硬骨素蛋白表位有关的组合物和方法,以及硬骨素结合剂,例如能结合硬化蛋白的抗体。
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公开(公告)号:US07592429B2
公开(公告)日:2009-09-22
申请号:US11411003
申请日:2006-04-25
申请人: Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
发明人: Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译: 提供了与硬骨素蛋白表位有关的组合物和方法,以及硬骨素结合剂,例如能结合硬化蛋白的抗体。
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