公开(公告)号：US10376502B2

公开(公告)日：2019-08-13

申请号：US14813931

申请日：2015-07-30

申请人： Baruch S. Blumberg Institute ,  Drexel University

发明人： Yanming Du ,  Xiaodong Xu ,  Hong Ye ,  Jinhong Chang ,  Timothy M. Block

IPC分类号： A61K31/45 ,  A61K31/4015 ,  C07F9/59 ,  C07D207/12 ,  C07D211/44 ,  C07D211/46 ,  C07D413/06

摘要： Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.

公开(公告)号：US09938236B2

公开(公告)日：2018-04-10

申请号：US14759385

申请日：2013-12-27

申请人： DREXEL UNIVERSITY ,  BARUCH S. BLUMBERG INSTITUTE ,  ARBUTUS BIOPHARMA, INC.

发明人： Xiaodong Xu ,  Ju-Tao Guo ,  Tong Xiao ,  Yanming Du ,  Timothy Block ,  Simon David Peter Baugh ,  Hong Ye

IPC分类号： C07C311/16 ,  C07D213/75 ,  C07D213/76 ,  C07D309/04 ,  C07D215/38 ,  C07D215/42 ,  C07D217/24 ,  C07D319/18 ,  C07D231/40 ,  C07D231/42 ,  C07D239/26 ,  C07D261/14 ,  C07D263/48 ,  C07D263/50 ,  C07D203/26 ,  C07D263/58 ,  C07D205/04 ,  C07D277/46 ,  C07D277/52 ,  C07D211/96 ,  C07D295/26 ,  C07D295/30 ,  C07D213/40 ,  C07D305/08 ,  C07C309/89 ,  C07C311/17 ,  C07C311/18 ,  C07C311/19 ,  C07C311/20 ,  C07C311/48 ,  C07C233/66 ,  C07C317/14 ,  C07D295/32 ,  C07D319/16

CPC分类号： C07C311/16 ,  C07B2200/07 ,  C07C233/66 ,  C07C309/89 ,  C07C311/17 ,  C07C311/18 ,  C07C311/19 ,  C07C311/20 ,  C07C311/48 ,  C07C317/14 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D203/26 ,  C07D205/04 ,  C07D211/96 ,  C07D213/40 ,  C07D213/75 ,  C07D213/76 ,  C07D215/38 ,  C07D215/42 ,  C07D217/24 ,  C07D231/40 ,  C07D231/42 ,  C07D239/26 ,  C07D261/14 ,  C07D263/48 ,  C07D263/50 ,  C07D263/58 ,  C07D277/46 ,  C07D277/52 ,  C07D295/26 ,  C07D295/30 ,  C07D295/32 ,  C07D305/08 ,  C07D309/04 ,  C07D319/16 ,  C07D319/18

摘要： The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.

公开(公告)号：US20150335630A1

公开(公告)日：2015-11-26

申请号：US14813931

申请日：2015-07-30

申请人： Baruch S. Blumberg Institute ,  Drexel University

发明人： Yanming Du ,  Xiaodong Xu ,  Hong Ye ,  Jinhong Chang ,  Timothy M. Block

IPC分类号： A61K31/45 ,  A61K31/4015

CPC分类号： A61K31/45 ,  A61K31/4015 ,  C07D207/12 ,  C07D211/44 ,  C07D211/46 ,  C07D413/06 ,  C07F9/59

摘要： Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.

摘要翻译： 本发明的药物组合物包含在治疗与葡萄糖苷酶活性相关的疾病（包括病毒性出血热）和涉及葡糖苷酶活性的任何其它疾病中具有疾病修饰作用的烷基化亚氨基糖衍生物。

公开(公告)号：US10421723B2

公开(公告)日：2019-09-24

申请号：US15492652

申请日：2017-04-20

申请人： Baruch S. Blumberg Institute

发明人： Yanming Du ,  Jinhong Chang ,  Timothy Michael Block

IPC分类号： C07D211/40 ,  C07D211/36 ,  C07D419/12 ,  A61K31/45 ,  A61K31/13

摘要： Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include viral hemorrhagic fevers and other enveloped viruses, and any other diseases involving glucosidase activity.

公开(公告)号：US20230151021A1

公开(公告)日：2023-05-18

申请号：US17920663

申请日：2021-04-27

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  BARUCH S. BLUMBERG INSTITUTE

发明人： Erle S. Robertson ,  Yonggang Pei ,  Yanming Du

IPC分类号： C07D493/08 ,  A61P35/02

CPC分类号： C07D493/08 ,  A61P35/02

摘要： The present disclosure relates, in part, to certain compounds comprising brusatol derivatives, or a pharmaceutically acceptable salt, solvate, or polymorph thereof, which are useful for the treatment of hematological malignancies, including but not limited to leukemia and lymphoma. In certain embodiments, the present disclosure relates to pharmaceutical compositions of the compounds of the present disclosure.

公开(公告)号：US09126937B2

公开(公告)日：2015-09-08

申请号：US14388175

申请日：2013-03-27

申请人： Baruch S. Blumberg Institute ,  Philadelphia Health & Education Corporation

发明人： Yanming Du ,  Xiaodong Xu ,  Hong Ye ,  Jinhong Chang ,  Timothy M. Block

IPC分类号： C07D211/40 ,  A61K31/445 ,  C07D211/46 ,  C07D413/06 ,  C07F9/59

CPC分类号： A61K31/45 ,  A61K31/4015 ,  C07D207/12 ,  C07D211/44 ,  C07D211/46 ,  C07D413/06 ,  C07F9/59

摘要： Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.

摘要翻译： 本发明的药物组合物包含在治疗与葡萄糖苷酶活性相关的疾病（包括病毒性出血热）和涉及葡糖苷酶活性的任何其它疾病中具有疾病修饰作用的烷基化亚氨基糖衍生物。

公开(公告)号：US20210371388A1

公开(公告)日：2021-12-02

申请号：US17318680

申请日：2021-05-12

申请人： Baruch S. Blumberg Institute

发明人： Yanming Du ,  Ju-Tao Guo ,  Nicky Hwang

IPC分类号： C07D241/52 ,  C07D241/48 ,  C07D215/233 ,  C07D279/16 ,  C07D265/36 ,  C07D241/04

摘要： Pharmaceutical compositions of the invention comprise functionalized bicyclic carboxamide useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.

公开(公告)号：US10913734B2

公开(公告)日：2021-02-09

申请号：US16317191

申请日：2017-07-11

申请人： BARUCH S. BLUMBERG INSTITUTE

发明人： Yanming Du ,  Huagang Lu ,  John Rogowsky ,  William A. Kinney ,  Andrea Cuconati

IPC分类号： C07D417/14 ,  C07D401/14 ,  A61P35/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/20 ,  C07F9/6558

摘要： Described herein are substituted aminothiazoles, compositions comprising same; and methods of making and using same.

公开(公告)号：US20170305856A1

公开(公告)日：2017-10-26

申请号：US15492652

申请日：2017-04-20

申请人： Baruch S. Blumberg Institute

发明人： Yanming Du ,  Jinhong Chang ,  Timothy Michael Block

IPC分类号： C07D211/40 ,  C07C9/15 ,  A61K31/13 ,  A61K31/45 ,  C07D419/12 ,  C07D211/36

摘要： Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include viral hemorrhagic fevers and other enveloped viruses, and any other diseases involving glucosidase activity.

公开(公告)号：US20150119366A1

公开(公告)日：2015-04-30

申请号：US14388175

申请日：2013-03-27

申请人： Baruch S. Bulumberg Institute ,  Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine

发明人： Yanming Du ,  Xiaodong Xu ,  Hong Ye ,  Jinhong Chang ,  Timothy M. Block

IPC分类号： C07D211/46 ,  C07F9/59 ,  C07D413/06

CPC分类号： A61K31/45 ,  A61K31/4015 ,  C07D207/12 ,  C07D211/44 ,  C07D211/46 ,  C07D413/06 ,  C07F9/59

摘要： Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.