-
公开(公告)号：US20240083857A1
公开(公告)日：2024-03-14
申请号：US18350246
申请日：2023-07-11
发明人： Lars WORTMANN , Brice SAUTIER , Knut EIS , Hans BRIEM , Niels BOHNKE , Franz VON NUSSBAUM , Roman HILLIG , Benjamin BADER , Jens SCHRODER , Kirstin PETERSEN , Philip LIENAU , Antje Margret WENGNER , Dieter MOOSMAYER , Qiuwen WANG , Hans SCHICK
IPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D405/14 , C07D405/10 , C07D495/04 , C07D403/04 , C07D487/04 , A61P35/00
CPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D405/14 , C07D405/10 , C07D495/04 , C07D403/04 , C07D487/04 , A61P35/00
摘要： The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula (I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20180148418A1
公开(公告)日：2018-05-31
申请号：US15571414
申请日：2016-05-02
发明人： Knut EIS , Jens ACKERSTAFF , Sarah WAGNER , Philipp BUCHGRABER , Detlev SÜLZLE , Simon HOLTON , Eckhard BENDER , Volkhart LI , Ningshu LIU , Franziska SIEGEL , Philip LIENAU , Michaela BAIRLEIN , Franz VON NUSSBAUM , Simon Anthony HERBERT , Marcus KOPPITZ
IPC分类号： C07D233/90 , C07D495/10 , A61P35/04 , C07D487/10 , C07D487/04 , C07D417/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D403/06 , C07D401/14 , C07D401/12 , C07D263/34 , A61K45/06 , A61K31/554 , A61K31/5377 , A61K31/519 , A61K31/5025 , A61K31/454 , A61K31/4439 , A61K31/421 , A61K31/4178 , A61K31/4164 , A61K31/4155 , A61P35/00 , C07D491/107
CPC分类号： C07D233/90 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/454 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/554 , A61K45/06 , A61P35/00 , A61P35/04 , C07D233/54 , C07D263/34 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D487/04 , C07D487/10 , C07D487/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
-
公开(公告)号：US20220274979A1
公开(公告)日：2022-09-01
申请号：US17048561
申请日：2019-04-15
发明人： Lars WORTMANN , Brice SAUTIER , Knut EIS , Hans BRIEM , Niels BÖHNKE , Franz VON NUSSBAUM , Roman HILIG , Benjamin BADER , Jens SCHRÖDER , Kirstin PETERSEN , Philip LIENAU , Antje Margret WENGNER , Dieter MOOSMAYER , Qiuwen WANG , Hans SCHICK
IPC分类号： C07D471/04 , C07D487/04
摘要： The present invention covers 2-methyl-aza-quinazoline compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients
-
公开(公告)号：US20180256591A1
公开(公告)日：2018-09-13
申请号：US15974536
申请日：2018-05-08
发明人： Lars WORTMANN , Ulrich LÜCKING , Julien LEFRANC , Hans BRIEM , Marcus KOPPITZ , Knut EIS , Franz VON NUSSBAUM , Benjamin BADER , Antje Margret WENGNER , Gerhard SIEMEISTER , Wilhelm BONE , Philip LIENAU , Joanna GRUDZINSKA-GOEBEL , Dieter MOOSMAYER , Uwe EBERSPÄCHER , Hans SCHICK
IPC分类号： A61K31/541 , A61K31/55 , A61K31/5377 , A61K31/5386 , C07D471/04 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20170216304A1
公开(公告)日：2017-08-03
申请号：US15501079
申请日：2015-08-03
发明人： Lars WORTMANN , Ulrich LÜCKING , Julien LEFRANC , Hans BRIEM , Marcus KOPPITZ , Knut EIS , Franz VON NUSSBAUM , Benjamin BADER , Antje Margret WENGNER , Gerhard SIEMEISTER , Wilhelm BONE , Philip LIENAU , Joanna GRUDZINSKA-GOEBEL , Dieter MOOSMAYER , Uwe EBERSPÄCHER , Hans SCHICK
IPC分类号： A61K31/541 , A61K31/5386 , A61K31/5377 , C07D491/22 , C07F9/6561 , C07D471/04 , C07D519/00 , A61K31/55 , A61K31/675
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20220235013A1
公开(公告)日：2022-07-28
申请号：US16496825
申请日：2018-03-19
发明人： Lars WORTMANN , Brice SAUTIER , Knut EIS , Hans BRIEM , Niels BOHNKE , Franz VON NUSSBAUM , Roman HILLIG , Benjamin BADER , Jens SCHRODER , Kirstin PETERSEN , Philip LIENAU , Antje Margret WENGNER , Dieter MOOSMAYER , Qiuwen WANG , Hans SCHICK
IPC分类号： C07D239/94 , C07D409/12 , C07D405/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D413/12 , C07D401/12 , C07D409/14 , C07D413/14
摘要： The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions.
The 2-methyl substituted quinazoline compounds of general formula (I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.-
公开(公告)号：US20200216439A1
公开(公告)日：2020-07-09
申请号：US16063134
申请日：2016-12-12
发明人： Keith GRAHAM , Ulrich KLAR , Hans BRIEM , Gerhard SIEMEISTER , Ursula MÖNNING , Franz VON NUSSBAUM
IPC分类号： C07D471/04 , C07D495/04 , C07D491/052 , A61P35/04
摘要： Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.037 秒)
