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    Host Cell Modification with Artificial Endosymbionts
    6.
    发明申请
    Host Cell Modification with Artificial Endosymbionts 审中-公开

    公开(公告)号：US20190112581A1

    公开(公告)日：2019-04-18

    申请号：US16225610

    申请日：2018-12-19

    申请人： BELL BIOSYSTEMS, INC.

    发明人： Caleb B. Bell, III ,  Alexey Bazarov ,  Abdul Wakeel ,  Joyce Barrozo

    IPC分类号： C12N5/16 ,  C07K14/195 ,  C12N15/87

    摘要： The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.

    Host cell modification with artificial endosymbionts
    9.
    发明授权
    Host cell modification with artificial endosymbionts 有权
    用人造内分泌素进行宿主细胞修饰

    公开(公告)号：US09481869B2

    公开(公告)日：2016-11-01

    申请号：US14476584

    申请日：2014-09-03

    申请人： BELL BIOSYSTEMS, INC.

    发明人： Caleb B. Bell, III ,  Alexey Bazarov ,  Abdul Wakeel ,  Joyce Barrozo

    IPC分类号： C12P21/02 ,  C12N15/87 ,  C12N5/16 ,  C12N5/00 ,  C12N15/02 ,  C12N15/09

    CPC分类号： C12N5/16 ,  C07K14/195 ,  C07K2319/034 ,  C12N15/87 ,  C12N2510/00

    摘要： The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.

    摘要翻译： 本发明一般涉及具有人造内分泌物的宿主细胞，其中人造内共生体和宿主细胞彼此连通以改变宿主细胞的表型。 在一些实施方案中，通信包括将多肽从人造内分泌物分泌到宿主细胞中。 分泌的多肽可以是可以在宿主细胞中产生表型的选择性标记，报道蛋白，转录因子，信号通路蛋白，受体，生长因子，细胞因子，效应分子或其他因子。

    Systems for Making Host Cells with Artificial Endosymbionts
    10.
    发明申请
    Systems for Making Host Cells with Artificial Endosymbionts 审中-公开
    用人造内分泌物制备宿主细胞的系统

    公开(公告)号：US20150225687A1

    公开(公告)日：2015-08-13

    申请号：US14620691

    申请日：2015-02-12

    申请人： BELL BIOSYSTEMS, INC.

    发明人： Caleb Bell, III ,  Alexey Bazarov ,  Brad Rice

    IPC分类号： C12M1/42 ,  C12Q1/66

    CPC分类号： C12M35/06

    摘要： The present invention is directed generally to systems for making host cells with artificial endosymbionts. In an embodiment, the systems of the invention comprise a host cell, an artificial endosymbiont, a means for introducing the artificial endosymbiont to the host cell, a means for separating the host cells with artificial endosymbionts from free artificial endosymbionts, and a means for detecting artificial endosymbionts in host cells.

    摘要翻译： 本发明一般涉及用于制造具有人造内分泌物的宿主细胞的系统。 在一个实施方案中，本发明的系统包括宿主细胞，人造内分泌物，用于将人造内共生体引入宿主细胞的手段，用于将人造内共生体与游离的人造内共生体分离的方法，以及用于检测 宿主细胞中的人造内共生体。