公开(公告)号：US5152998A

公开(公告)日：1992-10-06

申请号：US834454

申请日：1992-02-12

申请人： Benito Casu ,  Ennio Lanzarotti ,  Giangiacomo Torri ,  Annamaria Naggi ,  Armando Cedro

发明人： Benito Casu ,  Ennio Lanzarotti ,  Giangiacomo Torri ,  Annamaria Naggi ,  Armando Cedro

IPC分类号： C07H15/10 ,  C08B37/00

CPC分类号： C07H15/10 ,  C08B37/0015 ,  Y10S514/885

摘要： By ultrafiltration of an aqueous solution wherein there have been formerly dissolved alfa-cyclodextrin and a raw lipidic mixture, the latter characterized in that it contains monosialoganglioside (GMl) either as the sole ganglioside or otherwise in a prevailing quantity over the other associated gangliosides, and after the removal of cyclodextrin at the end of the process, it is obtained GMl with a titer of at least 95%. The present invention concerns also the intermediate complex that it is being formed between the hereabove said monosialoganglioside and alfa-cyclodextrin.

摘要翻译： 通过超滤其中先前已经溶解的α-环糊精和原始脂质混合物的水溶液，后者的特征在于其包含单唾液酸神经节苷脂（GM1）作为唯一的神经节苷脂，或以其他相关的神经节苷脂为主要量，以及 在该方法结束后除去环糊精后，得到滴度为至少95％的GM1。 本发明还涉及其在上述单唾液酸神经节苷脂与α-环糊精之间形成的中间体复合物。

公开(公告)号：US5110918A

公开(公告)日：1992-05-05

申请号：US587605

申请日：1990-09-24

申请人： Benito Casu ,  Annamaria Naggi ,  Pasqua Oreste ,  Giangiacomo Torri ,  Giorgio Zoppetti ,  Giancarlo Sportoletti ,  Francesco De Santis

发明人： Benito Casu ,  Annamaria Naggi ,  Pasqua Oreste ,  Giangiacomo Torri ,  Giorgio Zoppetti ,  Giancarlo Sportoletti ,  Francesco De Santis

IPC分类号： C08B37/10 ,  A61K31/715 ,  A61P7/02 ,  C08B37/00

CPC分类号： C08B37/0075

摘要： Heparins, heparin fractions or fragments, optionally salified with pharmaceutically acceptable cations, having molecular weight ranging from 1.000 to 30.000 D, characterized by an EDTA content lower than 0.1%, by the absence, in the .sup.1 H--NMR spectra, of the signals due to EDTA between 2.50 and 4.00 p.p.m. and substantially free from bleeding effect and optionally free from signals, in the .sup.13 C--NMR spectrum, from 80 to 86 ppm.

摘要翻译： 盐酸，肝素级分或片段，任选地与药学上可接受的阳离子盐化，其分子量范围为1.000至30.000D，其特征在于EDTA含量低于0.1％，在1H-NMR谱中不存在由于 EDTA在2.50和4.00 ppm之间 并且在13 C-NMR光谱中基本上没有出血作用并且任选地没有信号，从80至86ppm。

公开(公告)号：US06197943B1

公开(公告)日：2001-03-06

申请号：US09381451

申请日：1999-09-20

申请人： Benito Casu ,  Annamaria Naggi ,  Giangiacomo Torri

发明人： Benito Casu ,  Annamaria Naggi ,  Giangiacomo Torri

IPC分类号： C08B3710

CPC分类号： C08B37/0063 ,  C08B37/0075

摘要： Glycosaminoglycans having high antithrombotic activity in vitro, obtained by various kinds of glycosaminoglycans supersulfated by the preparation of the salt of an organic base of the starting supersaturated glycosaminoglycan, by partial solvolytic desulfation of said salt and N-resulfation of said partially desulfated product.

摘要翻译： 在体外具有高抗血栓活性的糖胺聚糖通过各种通过制备起始过饱和糖胺聚糖的有机碱的盐而被超硫酸化的糖胺聚糖，通过所述盐的部分溶剂解脱硫和所述部分脱硫产物的N-硫酸化得到。

公开(公告)号：US5008253A

公开(公告)日：1991-04-16

申请号：US346502

申请日：1989-05-02

申请人： Benito Casu ,  Giangiacomo Torri ,  Annamaria Naggi ,  Marisa Mantovani ,  Rodolfo Pescador ,  Roberto Porta ,  Giuseppe Prino

发明人： Benito Casu ,  Giangiacomo Torri ,  Annamaria Naggi ,  Marisa Mantovani ,  Rodolfo Pescador ,  Roberto Porta ,  Giuseppe Prino

IPC分类号： A61K31/715 ,  A61P7/02 ,  C08B37/08 ,  C08B37/10

CPC分类号： C08B37/0069 ,  C08B37/0072

摘要： Novel derivatives are disclosed as obtained from chondroitin sulfate, dermatan sulfate and hyaluronic acid, having a molar ratio between sulfate groups and carboxylic groups like that of heparin and furthermore characterized by possessing, as the heparin, the sulfoamino group at the carbon atom at the 6 position of hexosamine.The novel compounds show a very remarkable clearing activity in comparison with the starting mucopolysaccharides, this activity being similar and for some derivatives comparable with that of heparin.Moreover, differently from what normally happens upon sulfating the sulfomucopolysaccharides, the anticoagulating activity of the novel compounds is negligible or anyhow very reduced.The compounds of the present invention find use in the therapy of arteriosclerosis.

公开(公告)号：US07208479B2

公开(公告)日：2007-04-24

申请号：US10824549

申请日：2004-04-14

申请人： Annamaria Naggi ,  Enrico Petrella ,  Giangiacomo Torri ,  Benito Casu

发明人： Annamaria Naggi ,  Enrico Petrella ,  Giangiacomo Torri ,  Benito Casu

IPC分类号： A01N43/04 ,  A61K31/715 ,  A61K39/00

CPC分类号： A61K31/718

摘要： The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.

摘要翻译： 本发明提供了含有热稳定性渗透剂如D-葡萄糖，葡萄糖酸和烷基糖苷的腹膜透析溶液，其分别产生了icodextrin的还原，氧化或糖基化。 因此，提供了在高压灭菌或加热灭菌条件下稳定的渗透剂，其减少了无菌的腹膜透析溶液中的生物相容性材料的量。 公开了制备D-葡萄糖醇，葡糖酸和烷基糖苷类的方法。

公开(公告)号：US07005508B2

公开(公告)日：2006-02-28

申请号：US10362811

申请日：2001-08-10

申请人： Francesca Benedini ,  Benito Casu ,  Piero Del Soldato ,  Paolo Gresele ,  Annamaria Naggi ,  Giangiacomo Torri ,  Simona Venturini

发明人： Francesca Benedini ,  Benito Casu ,  Piero Del Soldato ,  Paolo Gresele ,  Annamaria Naggi ,  Giangiacomo Torri ,  Simona Venturini

IPC分类号： C07H5/04 ,  C07H1/00 ,  C08B37/08 ,  C08B37/10 ,  A61K31/727

CPC分类号： C08B37/0075 ,  C08B37/0063

摘要： The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic acid and/or hexosamine, containing nitro groups —ONO2 covalently bonded to the saccharide structure. Preferably, the polysaccharides according to the invention are prevalently formed of disaccharide repeating units formed of uronic acid and hexosamine. These compounds, in psychological conditions, selectively release NO, allowing a reduction in the amount of NO needed to achieve a determined therapeutical effect. This result has been achieved by functionalizing polysaccharides essentially formed of units of uronic acid and/or hexosamine, with subsituents containing a ONO2 ? group.

摘要翻译： 本发明提供了与组织和有机流体具有高相容性的新类化合物。 这些新化合物是基本上由糖醛酸和/或己糖胺的单元形成的多糖，其含有与糖结构共价结合的硝基-ONO 2。 优选地，根据本发明的多糖优选由由糖醛酸和己糖胺形成的二糖重复单元形成。 这些化合物在心理条件下选择性地释放NO，允许减少实现确定的治疗效果所需的NO量。 通过官能化基本上由糖醛酸和/或己糖胺形成的多糖来实现该结果，其中含有ONO的取代基包含ONO 2？ 组。

公开(公告)号：US20050137167A1

公开(公告)日：2005-06-23

申请号：US10489359

申请日：2001-09-12

申请人： Benito Casu ,  Giangiacomo Torri ,  Annamaria Naggi ,  Claudio Pisano ,  Giuseppe Giannini ,  Sergio Penco

发明人： Benito Casu ,  Giangiacomo Torri ,  Annamaria Naggi ,  Claudio Pisano ,  Giuseppe Giannini ,  Sergio Penco

IPC分类号： A61K47/36 ,  A61K31/727 ,  A61K45/00 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P11/06 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C08B37/00 ,  C08B37/10 ,  C07H5/04

CPC分类号： A61K31/727 ,  C08B37/0075 ,  C08B37/0078

摘要： Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. Said glycosaminoglycan derivatives are endowed with antiangiogenic and heparanase-inhibiting activity ans are devoid of anticoagulant activity.

摘要翻译： 描述了部分脱硫的糖胺聚糖衍生物，特别是肝素，更具体地，其中U，R和R 1个基团具有说明书中所示含义的式（I）化合物。 所述糖胺聚糖衍生物具有抗血管生成和乙酰肝素酶抑制活性，没有抗凝活性。

公开(公告)号：US06770148B1

公开(公告)日：2004-08-03

申请号：US09206063

申请日：1998-12-04

申请人： Annamaria Naggi ,  Enrico Petrella ,  Giangiacomo Torri ,  Benito Casu

发明人： Annamaria Naggi ,  Enrico Petrella ,  Giangiacomo Torri ,  Benito Casu

IPC分类号： C08B3000

CPC分类号： A61K31/718

摘要： The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.

公开(公告)号：US5108613A

公开(公告)日：1992-04-28

申请号：US729728

申请日：1991-07-15

申请人： Benito Casu ,  Ennio Lanzarotti ,  Giangiacomo Torri ,  Annamaria Naggi ,  Armando Cedro

发明人： Benito Casu ,  Ennio Lanzarotti ,  Giangiacomo Torri ,  Annamaria Naggi ,  Armando Cedro

IPC分类号： B01D61/00 ,  C07H1/08 ,  C07H15/10 ,  C08B37/00 ,  C08B37/16

CPC分类号： C07H15/10 ,  C08B37/0015

摘要： By ultrafiltration of an aqueous solution wherein there have been formerly dissolved alfa-cyclodextrin and a raw lipidic mixture, the latter characterized in that it contains monosialoganglioside (GM1) either as the sole ganglioside or otherwise in a prevailing quantity over the other associated gangliosides, and after the removal of cyclodextrin at the end of the process, it is obtained GM1 with a titer of at least 95%. The present invention concerns also the intermediate complex that it is being formed between the hereabove said monosialoganglioside and alfa-cyclodextrin.

公开(公告)号：US20120232263A1

公开(公告)日：2012-09-13

申请号：US13056085

申请日：2009-07-09

申请人： Giangiacomo Torri ,  Elena Vismara ,  Israel Vlodavsky ,  Annamaria Naggi

发明人： Giangiacomo Torri ,  Elena Vismara ,  Israel Vlodavsky ,  Annamaria Naggi

IPC分类号： C07H5/10

CPC分类号： C07H11/00 ,  C07H17/04

摘要： The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C—C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSO3− group is comprised between 50 and 100%. The sulfated oligosaccharides according to the invention are useful as a drug, in particular in the treatment of angiogenesis, metastasis, and inflammation.

摘要翻译： 本发明涉及具有4,5或6个糖苷单元的硫酸化低聚糖，并且其中两个糖单元之间的糖苷键被C-C键取代，并且其中所述硫酸化度表示为被OSO 3 - 组为50〜100％。 根据本发明的硫酸化寡糖可用作药物，特别是用于治疗血管生成，转移和炎症。