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1.发明申请Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof 审中-公开针对肿瘤相关抗原的单克隆抗体（MAb），其制备和应用公开(公告)号：US20060159682A1
公开(公告)日：2006-07-20
申请号：US10942929
申请日：2004-09-17
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions ═CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区-CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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2.发明授权Chimeric antibody against tumor associated antigens and its use in diagnosing tumors 失效针对肿瘤相关抗原的嵌合抗体及其在诊断肿瘤中的应用公开(公告)号：US07662383B2
公开(公告)日：2010-02-16
申请号：US12068545
申请日：2008-02-07
IPC分类号： A61K39/395 , C07K16/30 , C12P21/08
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区= CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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3.发明申请Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof 失效针对肿瘤相关抗原的单克隆抗体（MAb），其制备和应用公开(公告)号：US20090246132A1
公开(公告)日：2009-10-01
申请号：US12068545
申请日：2008-02-07
IPC分类号： A61K51/10 , C07K16/18 , C12N9/00 , A61K39/395 , C07K19/00 , C07K16/46 , C12P21/02 , A61P35/00 , G01N33/53
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区= CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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4.发明授权Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof 失效针对肿瘤相关抗原的单克隆抗体（MAb），其制备和应用公开(公告)号：US06926896B2
公开(公告)日：2005-08-09
申请号：US08356791
申请日：1994-12-13
IPC分类号： A61K38/00 , A61K39/395 , A61K47/00 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07K16/00 , C07K16/30 , C07K19/00 , C12P21/08 , G01N33/577
CPC分类号： C07K16/3084 , A61K38/00 , A61K47/68 , A61K47/6815 , A61K47/6817 , A61K47/6851 , A61K51/1045 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
摘要翻译： 本发明涉及针对肿瘤相关抗原的鼠单克隆抗体（MAb），A，B，C和D。 描述了这些MAb的V基因的几乎完整的核苷酸序列，使得相关的可变结构域可以放在一起以产生嵌合的MAb，或者通过将高变区（互补决定区= CDR）插入到 人类的MAb框架。 这种类型的抗体构建体可以用于人类治疗和体内诊断，而不存在用鼠MAb观察到的缺点。
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公开(公告)号：US5639621A
公开(公告)日：1997-06-17
申请号：US468661
申请日：1995-06-06
申请人： Klaus Bosslet , Peter Pfleiderer , Gerhard Seemann
发明人： Klaus Bosslet , Peter Pfleiderer , Gerhard Seemann
IPC分类号： A61B10/00 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C07K19/00 , C12N5/10 , C12N5/20 , C12N5/22 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C12N5/12
CPC分类号： C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3015 , C07K16/3038 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2319/00
摘要： The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), to the preparation and use thereof and to the use of the epitope defined by the antibody for diagnosis and therapy.
摘要翻译： 本发明涉及抗肿瘤相关抗原的单克隆抗体，其主要衍生自乳腺癌，卵巢和前列腺癌的肿瘤，以及另外与多形性上皮粘蛋白（PEM）反应的肺腺癌， 关于其制备和使用以及由抗体定义的表位用于诊断和治疗的用途。
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公开(公告)号：US20060292139A1
公开(公告)日：2006-12-28
申请号：US11135155
申请日：2005-05-23
申请人： Mathias Gehrmann , Gerhard Seemann , Klaus Bosslet , Jorg Czech
发明人： Mathias Gehrmann , Gerhard Seemann , Klaus Bosslet , Jorg Czech
IPC分类号： A61K39/395 , C07K16/12
CPC分类号： C12Y302/01031 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K16/18 , C07K2319/00 , C07K2319/02 , C12N9/00 , C12N9/2434 , C12N15/62
摘要： The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is composed of a single polypeptide chain. It is advantageous for covalently bonded carbohydrates to be present on the polypeptide chain.
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公开(公告)号：US5645817A
公开(公告)日：1997-07-08
申请号：US459310
申请日：1995-06-02
申请人： Gerhard Seemann , Klaus Bosslet
发明人： Gerhard Seemann , Klaus Bosslet
IPC分类号： A61K39/395 , A61K38/00 , A61K47/48 , A61K51/10 , A61P35/00 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/13 , C12N15/62 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , A61K39/44 , C07K16/28
CPC分类号： C07K16/3007 , A61K47/48569 , A61K47/48576 , A61K51/10 , A61K51/1093 , C07K16/30 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The present invention describes granulocyte-binding antibody constructs, which were derived from the monoclonal mouse antibody MAk BW 250/183 (EP-A1-0 388 914), as well as a process for their preparation and their use.
摘要翻译： 本发明描述了衍生自单克隆小鼠抗体MAK BW 250/183（EP-A1-0381814）的粒细胞结合抗体构建体，以及其制备方法及其应用。
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公开(公告)号：US5561119A
公开(公告)日：1996-10-01
申请号：US137167
申请日：1994-05-27
申请人： Jean-Claude Jacquesy , Jean-Pierre Gesson , Claude Monneret , Martine Mondon , Brigitte Renoux , Jean-Claude Florent , Michel Koch , Fran.cedilla.ois Tillequin , Hans H. Sedlacek , Manfred Gerken , Cenek Kolar , Gilbert Gaudel , Klaus Bosslet , J org Czech , Dieter Hoffman , Gerhard Seemann , Hans-Ulrich Schorlemmer , Gerhard Dickneite
发明人： Jean-Claude Jacquesy , Jean-Pierre Gesson , Claude Monneret , Martine Mondon , Brigitte Renoux , Jean-Claude Florent , Michel Koch , Fran.cedilla.ois Tillequin , Hans H. Sedlacek , Manfred Gerken , Cenek Kolar , Gilbert Gaudel , Klaus Bosslet , J org Czech , Dieter Hoffman , Gerhard Seemann , Hans-Ulrich Schorlemmer , Gerhard Dickneite
IPC分类号： A61K38/22 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K38/46 , A61K39/395 , A61P35/00 , A61P43/00 , C07F7/18 , C07H15/203 , C07H15/252 , C07H15/26 , A61K39/44 , C07C50/18 , C07H5/04
CPC分类号： C07H15/203 , C07F7/1852 , C07F7/1856 , C07H15/252 , C07H15/26
摘要： Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I). ##STR1##
摘要翻译： PCT No.PCT / FR92 / 00385 Sec。 371日期：1994年5月27日 102（e）日期1994年5月27日PCT提交1992年4月29日PCT公布。 出版物WO92 / 19639 日期：1992年11月12日描述了糖基化前体药物及其制备方法及其与肿瘤特异性免疫酶联用物质治疗癌症的用途。 这些蒽环类前体具有式（I）。 （一）
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9.发明授权
公开(公告)号：US5908790A
公开(公告)日：1999-06-01
申请号：US463087
申请日：1995-06-05
申请人： Klaus Bosslet , Peter Hermentin , Gerhard Seemann
发明人： Klaus Bosslet , Peter Hermentin , Gerhard Seemann
IPC分类号： C02F1/62 , B01D39/00 , C07K16/44 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , G01N33/84
CPC分类号： C07K16/44 , G01N33/5308 , G01N33/84
摘要： The invention relates to monoclonal antibodies (mAB) which bind to water-soluble complexones such as ethylenediamine tetraacetate (EDTA) or diethylenetriamine pentaacetate (DTPA) with high specificity and avidity and retain their high avidity and specificity for these complexones after complexing of EDTA or DTPA with metal ions. These mAB can therefore be used, e.g. coupled on filters or other supports, for removing toxic heavy metals which are complexed with EDTA or DTPA. Furthermore, these mAB are suitable as components of immunoassays (RIA, ELISA etc.) for the quantitative determination of EDTA or DTPA in aqueous solutions.
摘要翻译： 本发明涉及以高特异性和亲合力结合水溶性络合物例如乙二胺四乙酸（EDTA）或二亚乙基三胺五乙酸酯（DTPA）的单克隆抗体（mAB），并且在EDTA或DTPA复合后保持其对这些络合物的高亲合力和特异性 与金属离子。 因此，可以使用这些mAB。 耦合在过滤器或其他支持物上，用于去除与EDTA或DTPA复合的有毒重金属。 此外，这些mAB适用于在水溶液中定量测定EDTA或DTPA的免疫测定（RIA，ELISA等）的组分。
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10.发明授权Specific antibodies against activated platelets, the preparation thereof and the use thereof in diagnosis and therapy 失效针对活化血小板的特异性抗体，其制备方法及其在诊断和治疗中的应用
公开(公告)号：US5686583A
公开(公告)日：1997-11-11
申请号：US467393
申请日：1995-06-06
申请人： Klaus Bosslet , Gerhard Seemann , Beate Kehrel
发明人： Klaus Bosslet , Gerhard Seemann , Beate Kehrel
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , A61P7/02 , C07K14/00 , C07K14/705 , C07K14/78 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , G01N33/53 , C12N5/12
CPC分类号： C07K14/78 , C07K14/705 , C07K16/18 , C07K16/28 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/33
摘要： The invention relates to monoclonal antibodies and parts thereof which bind preferentially to active human platelets, to the nucleotide sequence and amino-acid sequence of the heavy and light chain of MAb BW 2128 and to an antigen associated with thrombospondin.
摘要翻译： 本发明涉及优先结合活性人血小板的单克隆抗体及其部分与MAb BW 2128的重链和轻链的核苷酸序列和氨基酸序列以及与血小板反应蛋白相关的抗原。
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