-
1.发明授权公开(公告)号：US08993332B2
公开(公告)日：2015-03-31
申请号：US12993517
申请日：2009-05-20
申请人： Bernhard Tewes , Rudolf Wilhelm
发明人： Bernhard Tewes , Rudolf Wilhelm
IPC分类号： C12Q1/68 , G01N1/28 , G01N1/30 , G01N1/44 , G01N15/10 , G01N33/00 , G01N33/48 , G01N33/50 , C12Q1/04 , C12Q1/66
CPC分类号： C12Q1/6888 , C12Q1/04 , C12Q1/66 , C12Q2600/158 , G01N33/5029 , G01N2333/43526
摘要： A method for determining the biological activity of embryonated Trichuris eggs is described, in which at least one of the following determinations is carried out: a) Determination and/or confirmation of the stage of the embryonal development of helminth eggs with the aid of quantitative PCR analysis by using suitable marker sequences for ascertaining the copy number of the genomic DNA, b) Determination of the metabolic activity of embryonated helminth eggs by means of biochemical and/or molecular biological methods, c) Determination of the inducibility of gene expression in embryonated helminth eggs, d) Microscopic determination of the motility of helminth larvae in the egg over long periods of observation after pre-incubation at increased temperatures and/or e) Determination of the hatching rate of Trichuris larvae in a laboratory animal, wherein the intact embryonated eggs recovered from the contents of the intestine are quantified compared to an internal standard.
摘要翻译： 描述了用于确定含胚的Trichuris卵的生物活性的方法，其中进行以下测定中的至少一个：a）借助定量PCR测定和/或确认蠕虫卵的胚胎发育阶段 通过使用合适的标记序列来确定基因组DNA的拷贝数进行分析，b）通过生物化学和/或分子生物学方法确定含胚蠕虫卵的代谢活性，c）确定胚胎蠕虫中基因表达的诱导性 鸡蛋，d）在升高的温度下预孵育后长时间观察卵中蠕虫幼虫的运动性的微观测定和/或e）确定实验动物中Trichuris幼虫的孵化率，其中完整的胚胎蛋 与内标相比，从肠内容物中回收。
-
2.发明申请Method For Characterising The Biological Activity Of Helminth Eggs, In Particular Trichuris Eggs 有权用于表征蠕虫卵的生物活性的方法，特别是三叶鸡蛋公开(公告)号：US20120060229A9
公开(公告)日：2012-03-08
申请号：US12993517
申请日：2009-05-20
申请人： Bernhard Tewes , Rudolf Wilhelm
发明人： Bernhard Tewes , Rudolf Wilhelm
CPC分类号： C12Q1/6888 , C12Q1/04 , C12Q1/66 , C12Q2600/158 , G01N33/5029 , G01N2333/43526
摘要： A method for determining the biological activity of embryonated Trichuris eggs is described, in which at least one of the following determinations is carried out: a) Determination and/or confirmation of the stage of the embryonal development of helminth eggs with the aid of quantitative PCR analysis by using suitable marker sequences for ascertaining the copy number of the genomic DNA, b) Determination of the metabolic activity of embryonated helminth eggs by means of biochemical and/or molecular biological methods, c) Determination of the inducibility of gene expression in embryonated helminth eggs, d) Microscopic determination of the motility of helminth larvae in the egg over long periods of observation after pre-incubation at increased temperatures and/or e) Determination of the hatching rate of Trichuris larvae in a laboratory animal, wherein the intact embryonated eggs recovered from the contents of the intestine are quantified compared to an internal standard.
摘要翻译： 描述了用于确定含胚的Trichuris卵的生物活性的方法，其中进行以下测定中的至少一个：a）借助定量PCR测定和/或确认蠕虫卵的胚胎发育阶段 通过使用合适的标记序列来确定基因组DNA的拷贝数进行分析，b）通过生物化学和/或分子生物学方法确定含胚蠕虫卵的代谢活性，c）确定胚胎蠕虫中基因表达的诱导性 鸡蛋，d）在升高的温度下预孵育后长时间观察卵中蠕虫幼虫的运动性的微观测定和/或e）确定实验动物中Trichuris幼虫的孵化率，其中完整的胚胎蛋 与内标相比，从肠内容物中回收。
-
3.发明申请Method For Characterising The Biological Activity Of Helminth Eggs, In Particular Trichuris Eggs 有权用于表征蠕虫卵，特别是三叶鸡蛋的生物活性的方法公开(公告)号：US20110191869A1
公开(公告)日：2011-08-04
申请号：US12993517
申请日：2009-05-20
申请人： Bernhard Tewes , Rudolf Wilhelm
发明人： Bernhard Tewes , Rudolf Wilhelm
CPC分类号： C12Q1/6888 , C12Q1/04 , C12Q1/66 , C12Q2600/158 , G01N33/5029 , G01N2333/43526
摘要： A method for determining the biological activity of embryonated Trichuris eggs is described, in which at least one of the following determinations is carried out: a) Determination and/or confirmation of the stage of the embryonal development of helminth eggs with the aid of quantitative PCR analysis by using suitable marker sequences for ascertaining the copy number of the genomic DNA, b) Determination of the metabolic activity of embryonated helminth eggs by means of biochemical and/or molecular biological methods, c) Determination of the inducibility of gene expression in embryonated helminth eggs, d) Microscopic determination of the motility of helminth larvae in the egg over long periods of observation after pre-incubation at increased temperatures and/or e) Determination of the hatching rate of Trichuris larvae in a laboratory animal, wherein the intact embryonated eggs recovered from the contents of the intestine are quantified compared to an internal standard.
摘要翻译： 描述了一种用于确定含胚的Trichuris卵的生物活性的方法，其中进行以下测定中的至少一个：a）借助定量PCR测定和/或确认蠕虫卵的胚胎发育阶段 通过使用合适的标记序列来确定基因组DNA的拷贝数进行分析，b）通过生物化学和/或分子生物学方法确定含胚蠕虫卵的代谢活性，c）确定胚胎蠕虫中基因表达的诱导性 蛋，d）在升高的温度下预孵育后长时间观察卵中蠕虫幼虫的运动性的显微测定和/或e）测定实验动物中Trichuris幼虫的孵化率，其中完整的胚胎蛋 与内标相比，从肠内容物中回收。
-
4.发明授权Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size 有权优化了具有规定粒径的纯非多晶型结晶胆汁酸的合成公开(公告)号：US09512167B2
公开(公告)日：2016-12-06
申请号：US13989012
申请日：2011-11-30
IPC分类号： A61K31/575 , C07J9/00 , C07J7/00
CPC分类号： C07J9/005 , C07B2200/13 , C07J7/008 , Y10T428/2982
摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.
摘要翻译： 本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。 本发明还提供了包含本发明多晶型物的药物组合物和制备该多晶型物的方法。 本发明包括本发明的多晶型物或药物组合物的药物用途。
-
公开(公告)号：US20110123460A1
公开(公告)日：2011-05-26
申请号：US13054844
申请日：2009-07-02
申请人： Rudolf Wilhelm , Pröls Markus
发明人： Rudolf Wilhelm , Pröls Markus
CPC分类号： A61K31/58 , A61K9/0007 , A61K9/0095
摘要： The invention relates to an effervescent tablet for preparing a mouth rinsing solution, wherein the effervescent tablet exhibits a high release rate of budesonide. A high availability of the active ingredient during use as a mouth rinsing solution on the inflamed mucosa of the upper digestive tract is thereby achieved. The advantage of the formulation according to the invention lies in the bioavailability comparable to oral forms of administration, which allows the formulation to be used safely over an extended period of time.
摘要翻译： 本发明涉及一种用于制备口腔清洗溶液的泡腾片剂，其中泡腾片剂表现出布地奈德的高释放速率。 因此，在使用期间活性成分的高可用性作为上消化道的发炎粘膜上的口腔清洗溶液。 根据本发明的制剂的优点在于与口服给药形式相当的生物利用度，其允许制剂在延长的时间段内安全使用。
-
6.发明申请Optimized Synthesis Of Pure, Non-Polymorphic, Crystalline Bile Acids With Defined Particle Size 有权具有定义粒径的纯非多晶型结晶胆汁酸的优化合成公开(公告)号：US20140050791A1
公开(公告)日：2014-02-20
申请号：US13989012
申请日：2011-11-30
IPC分类号： C07J7/00
CPC分类号： C07J9/005 , C07B2200/13 , C07J7/008 , Y10T428/2982
摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The inventions further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.
摘要翻译： 本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。 本发明还提供包含本发明多晶型物的药物组合物和制备该多晶型物的方法。 本发明包括本发明的多晶型物或药物组合物的药物用途。
-
7.发明授权Method and system for speed-modified reproduction of video signals stored on video recording tape 失效视频记录磁带上存储的视频信号的速度修改再现方法和系统
公开(公告)号：US4210938A
公开(公告)日：1980-07-01
申请号：US908930
申请日：1978-05-24
申请人： Jurgen Heitmann , Rudolf Wilhelm
发明人： Jurgen Heitmann , Rudolf Wilhelm
摘要： A head wheel is rotated at a predetermined, essentially constant speed within a tape cylinder over which a tape is guided in a spiral path, on which video signal tracks are recorded in inclined track portions. The instantaneous position of the head wheel is determined, for example by a tacho generator applying signals to a counter, phase-synchronized by the outputs from the head wheel tacho generator. The instantaneous position of the tape is determined, for example from sensing the cross modulation of signals derived from the head as the head crosses from one track portion to another, or by sensing the phase jump of the pulse sequence of the horizontal synchronization signals; the two position signals are combined in a logic stage so that a line address can be derived of a signal transduced at any one instant by said head from an incremental area of the tape, the signal being associated with the line address for storage, for example in a memory for subsequent re-recording or reproduction at a time relation (slow motion or fast motion) differing from the original recording speed.
摘要翻译： 磁头轮以预定的基本上恒定的速度旋转，在磁带筒中，磁带在螺旋路径中被引导，在该磁道气缸中，视频信号轨道被记录在倾斜轨迹部分中。 头轮的瞬时位置例如由转子发生器通过来自头轮转速发生器的输出相位同步的计数器施加信号来确定。 确定磁带的瞬时位置，例如，当磁头从一个轨道部分到另一磁道部分交叉时，或者通过感测水平同步信号的脉冲序列的相位跳跃来感测从磁头导出的信号的交叉调制; 两个位置信号被组合在一个逻辑级中，使得可以从线的增量区域中的所有头在任何一瞬间转换的信号导出行地址，该信号与用于存储的行地址相关联，例如 在与原始记录速度不同的时间关系（慢动作或快速运动）中用于随后重新记录或再现的存储器中。
-
公开(公告)号：US4089026A
公开(公告)日：1978-05-09
申请号：US785764
申请日：1977-04-07
申请人： Rudolf Wilhelm , Jurgen Heitmann
发明人： Rudolf Wilhelm , Jurgen Heitmann
CPC分类号： H04N17/045
摘要： The invention provides an apparatus for producing video frequency color value signals which correspond to a desired arrangement of vertical or horizontal color bars on a television screen. In the case of vertical color bars the apparatus derives during each line period an identical series of pulses having a multiple of the line frequency. Each series of pulses is applied to a binary counter which provides as output a sequence of sets of binary signals. This sequence of sets of binary signals is translated by a pre-programmed store into a further sequence of sets of binary signals, these latter sets of signals being applied to a digital-to-analogue converter adapted to derive therefrom corresponding sets of color value signals. Each set of color value signals defines a differently colored line segment. The effect of this operation over a plurality of successive line periods is to build up a number of vertical color bars each composed of vertically adjacent line segments of the same color derived from identical sets of color value signals occurring in successive line periods.In the case of horizontal color bars the apparatus operates in a similar manner except that the series of pulses initially produced is at a fraction of the line frequency and is derived once for each field period rather than once for each line period.
摘要翻译： 本发明提供一种用于产生视频频率颜色值信号的装置，其对应于电视屏幕上垂直或水平色条的期望布置。 在垂直色条的情况下，装置在每个行周期中导出具有线频率的倍数的相同序列的脉冲。 每个脉冲串被施加到二进制计数器，该二进制计数器作为输出提供一组二进制信号。 二进制信号组的这一序列由预先编程的存储转换为二进制信号组的另一序列，这些后一组信号被施加到数模转换器，该数模转换器适于从其中导出对应的颜色值信号组 。 每组颜色值信号定义不同颜色的线段。 这种操作对多个连续的行周期的影响是建立多个垂直色条，每个垂直色条由相邻颜色的垂直相邻的线段组成，该线段由相继的行周期中出现的相同色彩值信号组合得到。
-
公开(公告)号：US08580300B2
公开(公告)日：2013-11-12
申请号：US13054844
申请日：2009-07-02
申请人： Rudolf Wilhelm , Pröls Markus
发明人： Rudolf Wilhelm , Pröls Markus
CPC分类号： A61K31/58 , A61K9/0007 , A61K9/0095
摘要： The invention relates to an effervescent tablet for preparing a mouth rinsing solution, wherein the effervescent tablet exhibits a high release rate of budesonide. A high availability of the active ingredient during use as a mouth rinsing solution on the inflamed mucosa of the upper digestive tract is thereby achieved. The advantage of the formulation according to the invention lies in the bioavailability comparable to oral forms of administration, which allows the formulation to be used safely over an extended period of time.
摘要翻译： 本发明涉及一种用于制备口腔清洗溶液的泡腾片剂，其中泡腾片剂表现出布地奈德的高释放速率。 因此，在使用期间活性成分的高可用性作为上消化道的发炎粘膜上的口腔清洗溶液。 根据本发明的制剂的优点在于与口服给药形式相当的生物利用度，其允许制剂在延长的时间段内安全使用。
-
公开(公告)号：US20110008390A1
公开(公告)日：2011-01-13
申请号：US12594074
申请日：2008-03-31
CPC分类号： A01N1/02 , A01N1/0205 , A01N1/0215 , A61K35/62
摘要： The present application describes a novel, advantageous purification method which guarantees the embryonation capability and the viability of a worm egg suspension. The T. suis worm eggs are first treated in a non-embryonated condition in a sulfuric acid solution at about=ph 2. Bacteria and viruses are thereby killed successfully. The germination number of yeasts and fungi is reduced. In a second step, the pH-value is increased and an orally tolerated preservative is added. Yeasts and fungi are thereby killed successfully. The suspension medium used in the second purification step can then be used as a culture medium for additional production (embryonation) and storage.
摘要翻译： 本申请描述了一种新颖的有利的纯化方法，其保证蠕虫卵悬液的胚胎能力和活力。 首先在大约= ph 2的硫酸溶液中以非含胚胎状态处理猪蛔虫卵。因此细菌和病毒被成功杀死。 酵母和真菌的发芽数量减少。 在第二步中，增加pH值并加入口服耐受性防腐剂。 因此，酵母和真菌被成功杀死。 然后可以将用于第二纯化步骤的悬浮介质用作用于额外生产（胚胎化）和储存的培养基。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.018 秒)
