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1.发明申请Modified viral particles with immunogenic properties and reduced lipid content useful for treating and preventing infectious diseases 失效具有免疫原性和改善的脂质含量的改良的病毒颗粒可用于治疗和预防感染性疾病公开(公告)号：US20050032222A1
公开(公告)日：2005-02-10
申请号：US10873015
申请日：2004-06-21
申请人： Bill Cham , Jo-Ann Maltais , Marc Bellotti
发明人： Bill Cham , Jo-Ann Maltais , Marc Bellotti
CPC分类号： A61K39/292 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , A61L2/0011 , A61L2/0088 , A61M1/3486 , C12N7/00 , C12N2730/10134 , C12N2730/10163 , C12N2740/15034 , C12N2740/15063 , C12N2770/20034 , C12N2770/24063 , C12N2770/24334 , C12N2770/24363
摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
摘要翻译： 本发明涉及一种减少感染性疾病，特别是感染性疾病的发生和严重性的方法，其中在生物流体例如血液中发现含有脂质的感染性病毒生物。 本发明使用可用于从含脂质感染性病毒生物体提取脂质的溶剂，从而产生具有降低的感染性和增强的抗原性的改性病毒颗粒。 本发明提供疫苗组合物，其包含具有降低的感染性和增强的抗原性的这些经修饰的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。 将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护。 本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。
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2.发明申请公开(公告)号：US20080234621A1
公开(公告)日：2008-09-25
申请号：US12054162
申请日：2008-03-24
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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3.发明申请公开(公告)号：US20080214438A1
公开(公告)日：2008-09-04
申请号：US12042924
申请日：2008-03-05
IPC分类号： A61K38/02
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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4.发明申请Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US20050004004A1
公开(公告)日：2005-01-06
申请号：US10796691
申请日：2004-03-08
申请人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
发明人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本方法可用于治疗动脉粥样硬化性血管疾病，并可与其他疗法（如他汀类药物，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制）结合使用。
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公开(公告)号：US5865793A
公开(公告)日：1999-02-02
申请号：US922795
申请日：1997-09-02
申请人： Ying-Cheng Lo , Marc Bellotti
发明人： Ying-Cheng Lo , Marc Bellotti
CPC分类号： A61J1/10 , A61M1/28 , Y10S128/24
摘要： A system and a method for administering a solution (12) from a container (10) to a patient (35) are provided. The container (10) is divided into a solution side (16) and a drain side (18) separated by a tear line (20). The solution side (16) and the drain side (18) are in fluid communication with one another and with a port (28) that connects to the patient (35). The container (10) is separable at the tear line (20) such that contents of a peritoneum cavity of the patient (35) may be drained into the drain side (18) of the container (10). Then, the solution (12) from the solution side (16) of the container (10) may be drained from the container (10) into the patient (35).
摘要翻译： 提供了一种从容器（10）向患者（35）施用溶液（12）的系统和方法。 容器（10）被分割成由撕开线（20）分开的溶液侧（16）和排出侧（18）。 溶液侧（16）和排出侧（18）彼此流体连通并且与连接到患者（35）的端口（28）流体连通。 容器（10）在撕裂线（20）处可分离，使得患者（35）的腹膜腔的内容物可以排出到容器（10）的排出侧（18）中。 然后，将来自容器（10）的溶液侧（16）的溶液（12）从容器（10）排出到患者（35）中。
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公开(公告)号：US4436620A
公开(公告)日：1984-03-13
申请号：US57387
申请日：1979-07-13
CPC分类号： A61M1/3621 , A61M1/3431 , A61M2205/12 , A61M2205/125
摘要： A one-piece hydraulic circuit is provided for use with a blood dialyzer for performing functions currently performed with a multiplicity of blood inlet and outlet sets and related items comprising flexible tubing and the like.
摘要翻译： 提供一体式液压回路，用于与血液透析器一起使用，用于执行目前执行的多种血液入口和出口组以及包括柔性管等的相关物品的功能。
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7.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US08637460B2
公开(公告)日：2014-01-28
申请号：US13601131
申请日：2012-08-31
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。
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8.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US08268787B2
公开(公告)日：2012-09-18
申请号：US13222287
申请日：2011-08-31
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本方法可用于治疗动脉粥样硬化性血管疾病，并可与其他疗法（如他汀类药物，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制）结合使用。
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9.发明申请Modified Viral Particles with Immunogenic Properties and Reduced Lipid Content Useful for Treating and Preventing Infectious Diseases 审中-公开用于治疗和预防传染病的具有免疫原性和降低脂质含量的改性病毒颗粒公开(公告)号：US20080267997A1
公开(公告)日：2008-10-30
申请号：US12118335
申请日：2008-05-09
申请人： Bill E. Cham , Jo-Ann B. Maltais , Marc Bellotti
发明人： Bill E. Cham , Jo-Ann B. Maltais , Marc Bellotti
CPC分类号： A61K39/292 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , A61L2/0011 , A61L2/0088 , A61M1/3486 , C12N7/00 , C12N2730/10134 , C12N2730/10163 , C12N2740/15034 , C12N2740/15063 , C12N2770/20034 , C12N2770/24063 , C12N2770/24334 , C12N2770/24363
摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
摘要翻译： 本发明涉及一种减少感染性疾病，特别是感染性疾病的发生和严重性的方法，其中在生物流体如血液中发现含有脂质的感染性病毒生物。 本发明使用可用于从含脂质感染性病毒生物体提取脂质的溶剂，从而产生具有降低的感染性和增强的抗原性的改性病毒颗粒。 本发明提供疫苗组合物，其包含具有降低的感染性和增强的抗原性的这些经修饰的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。 将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护。 本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。
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10.发明申请公开(公告)号：US20050090444A1
公开(公告)日：2005-04-28
申请号：US10996570
申请日：2004-11-23
申请人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
发明人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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