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公开(公告)号：US09618733B2
公开(公告)日：2017-04-11
申请号：US14444709
申请日：2014-07-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve Swihart , Evan Thrush , Evelio Perez , Kevin McDonald
IPC: G02B15/14
CPC classification number: G02B15/14
Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.
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公开(公告)号：US20160231272A1
公开(公告)日：2016-08-11
申请号：US15019792
申请日：2016-02-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Clayton T. McKee , Steve Swihart
IPC: G01N27/447
CPC classification number: G01N27/44739
Abstract: Kits, systems, and methods are provided for transferring biological macromolecules from an electrophoresis slab gel to a blotting membrane using conductive polymer electrodes.
Abstract translation: 提供了使用导电聚合物电极将生物大分子从电泳板凝胶转移到印迹膜的试剂盒，系统和方法。
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公开(公告)号：US09310600B2
公开(公告)日：2016-04-12
申请号：US14477253
申请日：2014-09-04
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan Thrush , Evelio Perez , Steve Swihart
CPC classification number: G02B21/361 , G01N21/00 , G01N21/76 , G02B17/023 , G02B21/0008 , G03B15/00 , G03B17/17
Abstract: An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region.
Abstract translation: 用于观察，成像和分析凝胶或其它基底中的生物，化学和/或生化样品的成像组件，其中可调节的相机和透镜模块，反射镜和焦平面镜配置成弯曲 或折叠光路以便对目标区域进行成像，并且其中可以沿非正交角度反射光路。 成像组件被配置为由于反射镜和相机和透镜组件相对于彼此定位的角度而减小成像装置的总体尺寸，这允许在目标区域中对相对较大的样本进行成像。
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公开(公告)号：US10326952B2
公开(公告)日：2019-06-18
申请号：US15675494
申请日：2017-08-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran , Steve Swihart , Evan Thrush , Itay Barak
Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.
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公开(公告)号：US20150070483A1
公开(公告)日：2015-03-12
申请号：US14477253
申请日：2014-09-04
Applicant: Bio-Rad Laboratories, Inc., LSG-LSD Division
Inventor： Evan Thrush , Evelio Perez , Steve Swihart
CPC classification number: G02B21/361 , G01N21/00 , G01N21/76 , G02B17/023 , G02B21/0008 , G03B15/00 , G03B17/17
Abstract: An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region.
Abstract translation: 用于观察，成像和分析凝胶或其它基底中的生物，化学和/或生化样品的成像组件，其中可调节的相机和透镜模块，反射镜和焦平面镜配置成弯曲 或折叠光路以便对目标区域进行成像，并且其中可以沿非正交角度反射光路。 成像组件被配置为由于反射镜和相机和透镜组件相对于彼此定位的角度而减小成像装置的总体尺寸，这允许在目标区域中对相对较大的样本进行成像。
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Patent Agency Ranking
公开(公告)号：US09945809B2
公开(公告)日：2018-04-17
申请号：US15019792
申请日：2016-02-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Clayton T. McKee , Steve Swihart
IPC: G01N27/447 , G01N27/453
CPC classification number: G01N27/44739
Abstract: Kits, systems, and methods are provided for transferring biological macromolecules from an electrophoresis slab gel to a blotting membrane using conductive polymer electrodes.
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公开(公告)号：US09736388B2
公开(公告)日：2017-08-15
申请号：US14563355
申请日：2014-12-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve Swihart , Evan Thrush , Boaz Ran
IPC: H04N7/12 , H04N11/04 , H04N11/02 , H04N5/235 , H04N5/361 , H04N5/217 , H04N5/355 , G01N21/76 , G01N21/27 , G01N21/64
CPC classification number: H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
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公开(公告)号：US20160028976A1
公开(公告)日：2016-01-28
申请号：US14563411
申请日：2014-12-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran , Steve Swihart , Evan Thrush , Itay Barak
Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.
Abstract translation: 本发明的一个实施例涉及一种包括包括像素阵列的图像传感器和与图像传感器耦合的掩模的成像装置，该掩模被配置为使像素阵列中的至少一个像素变暗。
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公开(公告)号：US20150029595A1
公开(公告)日：2015-01-29
申请号：US14444709
申请日：2014-07-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve Swihart , Evan Thrush , Evelio Perez , Kevin McDonald
IPC: G02B15/14
CPC classification number: G02B15/14
Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.
Abstract translation: 用于在凝胶或其它基底中观察，成像和分析化学发光或生物发光样品的成像组件，其中具有主要或固定透镜或聚焦透镜的可调节照相机和透镜模块移动以通过移动来改变视场 相机和镜头模块的焦平面。 成像组件还可以包括用于弯曲或折叠相机和透镜模块之间的光路的反射镜和具有样品的目标区域，其中反射镜可以在与相机和透镜模块相同的垂直方向上移动。 此外，相机和透镜模块可以被配置为相对于成像目标区域的位置在对角线方向上更多地移动。 成像组件还可以具有适于根据相机和透镜模块的运动进行调节的管道系统。
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公开(公告)号：US10186539B2
公开(公告)日：2019-01-22
申请号：US14875898
申请日：2015-10-06
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Evan Thrush , Steve Swihart , Hari Jayamohan
IPC: H04N1/00 , H01L27/146 , H01L23/34 , H01L31/024 , G01N21/15 , G01N21/64 , G01N21/76
Abstract: An image sensor assembly having a sensor window positioned in front of an image sensor, having structure and/or characteristics to prevent the formation of condensation on the sensor window. Structure to prevent the formation of condensation includes thin films which can have anti-condensation, anti-reflective, electrically conductive, and/or thermally conductive properties. The sensor window can further have a textured surface to displace water so as to avoid condensation formation on the window surface. The sensor window, and in some embodiments a frame, can be maintained at an elevated temperature proximate to the image sensor during operation to prevent the formation of condensation.
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