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公开(公告)号：US10326952B2
公开(公告)日：2019-06-18
申请号：US15675494
申请日：2017-08-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran , Steve Swihart , Evan Thrush , Itay Barak
Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.
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公开(公告)号：US20160258903A1
公开(公告)日：2016-09-08
申请号：US15059093
申请日：2016-03-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran
IPC: G01N27/447
CPC classification number: G01N27/44747 , G01N27/44739
Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.
Abstract translation: 提供了集成的电泳和电泳印制系统和方法。 在一个实施例中，盒包括分离凝胶和与分离凝胶的表面相邻的片，其中片被配置为在不打开盒的情况下从盒中取出。 还描述和说明了系统和方法。
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公开(公告)号：US09354179B2
公开(公告)日：2016-05-31
申请号：US13911115
申请日：2013-06-06
Applicant: Bio-Rad Laboratories Inc.
Inventor： Yochanan Uri , Boaz Ran , Ariel G. Notcovich , Shay Nimri
CPC classification number: G01N21/553 , G01N21/253 , G01N21/658 , G01N33/54373 , G01N2021/0328 , G01N2201/0407 , G01N2201/0484 , G01N2201/062
Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.
Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。
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公开(公告)号：US20160006910A1
公开(公告)日：2016-01-07
申请号：US14789717
申请日：2015-07-01
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yochanan Uri , Boaz Ran , Itay Barak , Steven Swihart , Evan Thrush
IPC: H04N5/225
CPC classification number: H04N5/2252 , G01N21/76 , G01N21/763 , G01N2201/0221
Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.
Abstract translation: 本文提供了用于检测发光和/或放射性信号的成像盒。 这样的盒可用于常见的生物测定，例如免疫测定，核苷酸检测测定和其他亲和测定。
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公开(公告)号：US20130330230A1
公开(公告)日：2013-12-12
申请号：US13911115
申请日：2013-06-06
Applicant: Bio-Rad Laboratories Inc.
Inventor： Yochanan URI , Boaz Ran , Ariel G. Notcovich , Shay Nimri
IPC: G01N21/65
CPC classification number: G01N21/553 , G01N21/253 , G01N21/658 , G01N33/54373 , G01N2021/0328 , G01N2201/0407 , G01N2201/0484 , G01N2201/062
Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.
Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。
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Patent Agency Ranking
公开(公告)号：US09383311B2
公开(公告)日：2016-07-05
申请号：US14013068
申请日：2013-08-29
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz Ran , Itay Barak
IPC: G01N21/00 , G01N21/552 , G02B3/00 , G02B5/00
CPC classification number: G01N21/553 , G02B3/005 , G02B5/008
Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
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公开(公告)号：US09736388B2
公开(公告)日：2017-08-15
申请号：US14563355
申请日：2014-12-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve Swihart , Evan Thrush , Boaz Ran
IPC: H04N7/12 , H04N11/04 , H04N11/02 , H04N5/235 , H04N5/361 , H04N5/217 , H04N5/355 , G01N21/76 , G01N21/27 , G01N21/64
CPC classification number: H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
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公开(公告)号：US20160028976A1
公开(公告)日：2016-01-28
申请号：US14563411
申请日：2014-12-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran , Steve Swihart , Evan Thrush , Itay Barak
Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.
Abstract translation: 本发明的一个实施例涉及一种包括包括像素阵列的图像传感器和与图像传感器耦合的掩模的成像装置，该掩模被配置为使像素阵列中的至少一个像素变暗。
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公开(公告)号：US11480565B2
公开(公告)日：2022-10-25
申请号：US16900577
申请日：2020-06-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Shai Nimri , Yochanan Uri , Boaz Ran
Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.
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公开(公告)号：US10104307B2
公开(公告)日：2018-10-16
申请号：US15667435
申请日：2017-08-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve Swihart , Evan Thrush , Boaz Ran
IPC: H04N7/12 , H04N11/02 , H04N11/04 , H04N5/235 , H04N5/355 , H04N5/361 , H04N5/365 , G01N21/76 , G01N21/64 , G01N21/27
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
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