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公开(公告)号：US07459169B2
公开(公告)日：2008-12-02
申请号：US10689869
申请日：2003-10-21
IPC分类号： A61F13/00
CPC分类号： A61L33/0017 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/42 , C08L71/02
摘要： Coatings comprising protein resistant components and therapeutic components on medical devices are disclosed. The coatings act to down-regulate complement activation. Medical devices can be coated with these coatings to prevent side effects and improve patency.
摘要翻译： 公开了在医疗装置上包含蛋白质抗性组分和治疗成分的涂层。 涂层用于下调补体活化。 医疗器械可以涂上这些涂层，以防止副作用并改善通畅。
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公开(公告)号：US08048437B2
公开(公告)日：2011-11-01
申请号：US11111468
申请日：2005-04-21
申请人： Bo Nilsson , Jonas Andersson , Karin Caldwell , Jennifer A. Neff , Kristina Nilsson-Ekdahl , Wade Akira Takeguchi
发明人： Bo Nilsson , Jonas Andersson , Karin Caldwell , Jennifer A. Neff , Kristina Nilsson-Ekdahl , Wade Akira Takeguchi
CPC分类号： A61L33/0017 , A61L27/34 , A61L29/085 , A61L31/10 , C08L71/02
摘要： Coatings comprising protein resistant components and therapeutic components on medical devices are disclosed. The coatings act to down-regulate complement activation. Medical devices can be coated with these coatings to prevent side effects and improve patency.
摘要翻译： 公开了在医疗装置上包含蛋白质抗性组分和治疗成分的涂层。 涂层用于下调补体活化。 医疗器械可以涂上这些涂层，以防止副作用并改善通畅。
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公开(公告)号：US07858108B2
公开(公告)日：2010-12-28
申请号：US10969541
申请日：2004-10-20
CPC分类号： A61L27/54 , A61K47/56 , A61K47/60 , A61L27/34 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/604 , C08L71/02
摘要： Elutable coatings comprising protein resistant components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved under controlled conditions.
摘要翻译： 公开了包含蛋白质抗性组分和在医疗装置上的生物活性剂的可洗涤涂层。 可洗涤涂层包含可在受控条件下裂解的不稳定接头。
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公开(公告)号：US07645721B2
公开(公告)日：2010-01-12
申请号：US10470296
申请日：2002-02-04
IPC分类号： C40B50/18
CPC分类号： C12N11/06
摘要： A method for coimmobilizing two or more biomolecules on a substrate in a defined ratio is disclosed. The method uses a copolymer conjugated to a number, N, of different types of oligonucleotides. The copolymer can be adsorbed to the surface of the substrate. N types of oligonucleotides complementary to the copolymer-bound oligonucleotides can be conjugated to N types of biomolecules. The types of the copolymer-bound oligonucleotides can be mixed in a defined ratio then adsorbed to the surface. The biomolecule-bound complementary oligonucletides can be conjugated to the copolymer-oligonucleotides to create a substrate with the biomolecules coimmobilized in a defined ratio. The invention also relates to a substrate prepared by the method of the invention.
摘要翻译： 公开了一种以规定的比例将两种或更多种生物分子以规定比例共轭化的方法。 该方法使用与N个不同类型的寡核苷酸缀合的共聚物。 共聚物可以吸附到基材的表面。 与共聚物结合的寡核苷酸互补的N型寡核苷酸可以与N型生物分子缀合。 共聚物结合的寡核苷酸的类型可以以确定的比例混合，然后吸附到表面。 生物分子结合的互补寡核苷酸可以与共聚物 - 寡核苷酸缀合以产生具有以规定比例共聚的生物分子的底物。 本发明还涉及通过本发明的方法制备的底物。
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公开(公告)号：US20110165244A1
公开(公告)日：2011-07-07
申请号：US12980293
申请日：2010-12-28
申请人： Jennifer A. Neff
发明人： Jennifer A. Neff
CPC分类号： A61L31/16 , A61K9/0014 , A61K47/56 , A61K47/60 , A61L27/52 , A61L27/54 , A61L31/145 , A61L2300/80
摘要： Elutable coatings and materials comprising protein resistant polymer components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved in response to a targeted physiologic stimulus. Medical devices formed from elutable materials comprised of protein resistant polymer components and bioactive agents are also disclosed. The elutable materials comprise labile linkers that can be cleaved in response to a targeted physiologic stimulus.
摘要翻译： 公开了在医疗装置上包含蛋白质抗性聚合物组分和生物活性剂的可洗涤涂料和材料。 可洗涤涂层包括可以响应于目标生理刺激而被切割的不稳定接头。 还公开了由可蛋白质聚合物组分和生物活性剂组成的可洗涤材料形成的医疗装置。 可洗涤材料包括可以响应于目标生理刺激而被切割的不稳定接头。
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公开(公告)号：US20140086865A1
公开(公告)日：2014-03-27
申请号：US14094577
申请日：2013-12-02
申请人： Pranav Joshi , Joseph McGuire , Jennifer A. Neff
CPC分类号： A01N25/10 , A01N25/34 , A01N63/02 , A23L3/3463 , A61K47/60 , A61K47/6957 , A61L2/232 , C08G65/3348 , C08G2650/58 , C08K9/08 , C08K2201/013 , C08L71/02 , C08L2205/05 , Y10T428/1352 , Y10T428/1376 , A01N43/90 , A01N2300/00 , C08L2666/02 , A01N37/46
摘要： The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
摘要翻译： 本发明基于以下认识：已知的抗微生物化合物，例如乳链菌肽或其它拉坦生物，可以通过将肽与嵌段聚合物如F108或端基活化聚合物连接形成长效的抗微生物表面涂层 （EGAP），以形成柔性系链和/或捕获肽。 捕获的肽通过早期释放释放而提供抗微生物作用，而束缚肽提供更持久的抗微生物保护。 可以使用含抗菌肽的嵌段共聚物来制备抗微生物凝胶和泡沫。
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公开(公告)号：US20120251592A1
公开(公告)日：2012-10-04
申请号：US13472346
申请日：2012-05-15
CPC分类号： A01N25/10 , A01N25/34 , A01N63/02 , A23L3/3463 , A61K47/48215 , A61K47/48992 , A61K47/60 , A61K47/6957 , A61L2/232 , C08G65/3348 , C08G2650/58 , C08K9/08 , C08K2201/013 , C08L71/02 , C08L2205/05 , Y10T428/1352 , Y10T428/1376 , A01N43/90 , A01N2300/00 , C08L2666/02 , A01N37/46
摘要： The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
摘要翻译： 本发明基于以下认识：已知的抗微生物化合物，例如乳链菌肽或其它拉坦生物，可以通过将肽与嵌段聚合物如F108或端基活化聚合物连接形成长效的抗微生物表面涂层 （EGAP），以形成柔性系链和/或捕获肽。 捕获的肽通过早期释放释放而提供抗微生物作用，而束缚肽提供更持久的抗微生物保护。 可以使用含抗菌肽的嵌段共聚物来制备抗微生物凝胶和泡沫。
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公开(公告)号：US20090022888A1
公开(公告)日：2009-01-22
申请号：US12171593
申请日：2008-07-11
IPC分类号： B05D1/18 , C08F279/02 , C08F283/10 , C08F283/00
CPC分类号： A01N25/10 , A01N25/34 , A01N63/02 , A23L3/3463 , A61K47/48215 , A61K47/48992 , A61K47/60 , A61K47/6957 , A61L2/232 , C08G65/3348 , C08G2650/58 , C08K9/08 , C08K2201/013 , C08L71/02 , C08L2205/05 , Y10T428/1352 , Y10T428/1376 , A01N43/90 , A01N2300/00 , C08L2666/02 , A01N37/46
摘要： The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
摘要翻译： 本发明基于认识到已知的抗微生物化合物，例如乳链菌肽或其他拉坦生物，可以通过将肽与嵌段聚合物如F108或端基连接而形成长效的抗微生物表面涂层 活化聚合物（EGAP），以形成柔性系链和/或捕获肽。 捕获的肽通过早期释放释放而提供抗微生物作用，而束缚肽提供更持久的抗微生物保护。 可以使用含抗菌肽的嵌段共聚物来制备抗微生物凝胶和泡沫。
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公开(公告)号：US10165773B2
公开(公告)日：2019-01-01
申请号：US14464589
申请日：2014-08-20
申请人： Jennifer A. Neff , Joseph McGuire , Pranav Joshi
IPC分类号： C08L71/02 , A01N25/10 , A01N25/34 , A23L3/3463 , A61K47/48 , C08G65/334 , C08K9/08 , A01N63/02 , A61L2/232
摘要： The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
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公开(公告)号：US20140356405A1
公开(公告)日：2014-12-04
申请号：US14464589
申请日：2014-08-20
申请人： Jennifer A. Neff , Joseph McGuire , Pranav Joshi
CPC分类号： A01N25/10 , A01N25/34 , A01N63/02 , A23L3/3463 , A61K47/60 , A61K47/6957 , A61L2/232 , C08G65/3348 , C08G2650/58 , C08K9/08 , C08K2201/013 , C08L71/02 , C08L2205/05 , Y10T428/1352 , Y10T428/1376 , A01N43/90 , A01N2300/00 , C08L2666/02 , A01N37/46
摘要： The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
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