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1.发明授权Method, system, and computer program product for improving the accuracy of glucose sensors using insulin delivery observation in diabetes 有权方法，系统和计算机程序产品，用于提高使用糖尿病胰岛素输送观察的葡萄糖传感器的准确度公开(公告)号：US09398869B2
公开(公告)日：2016-07-26
申请号：US13637359
申请日：2011-03-24
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1495 , A61M1/36 , A61M5/142
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/4839 , A61B5/7225 , A61B5/725 , A61B2560/0223 , A61M1/36 , A61M5/142
摘要： Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.
摘要翻译： 用于从胰岛素泵，人造胰腺或另一胰岛素递送装置提供信号的方法和系统作为用于提高连续葡萄糖传感器（CGS）的精度的信息来源。 使用胰岛素信息来提高传感器精度的效果在低血糖水平，即在降血糖范围内是最显着的，这在任何治疗中都是至关重要的。 一种用于提供可用于在时间t-τ确定葡萄糖状态估计的过滤/状态估计方法的系统。 估计可以外推到将来的某个时间t，然后外推值用于提取血糖分量。 对外推的血糖成分和CGS的输出进行加权，并用于估计受试者的血糖水平。
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2.发明申请METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IMPROVING THE ACCURACY OF GLUCOSE SENSORS USING INSULIN DELIVERY OBSERVATION IN DIABETES 有权方法，系统和计算机程序产品，用于提高糖尿病胰岛素输送观察葡萄糖传感器的准确性公开(公告)号：US20130079613A1
公开(公告)日：2013-03-28
申请号：US13637359
申请日：2011-03-24
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/4839 , A61B5/7225 , A61B5/725 , A61B2560/0223 , A61M1/36 , A61M5/142
摘要： Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.
摘要翻译： 用于从胰岛素泵，人造胰腺或另一胰岛素递送装置提供信号的方法和系统作为用于提高连续葡萄糖传感器（CGS）的精度的信息来源。 使用胰岛素信息来提高传感器精度的效果在低血糖水平，即在降血糖范围内是最显着的，这在任何治疗中都是至关重要的。 一种用于提供可用于在时间t-τ确定葡萄糖状态估计的过滤/状态估计方法的系统。 估计可以外推到将来的某个时间t，然后外推值用于提取血糖分量。 对外推的血糖成分和CGS的输出进行加权，并用于估计受试者的血糖水平。
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公开(公告)号：US11069434B2
公开(公告)日：2021-07-20
申请号：US13634040
申请日：2011-03-11
摘要： An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.
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4.发明授权公开(公告)号：US10420489B2
公开(公告)日：2019-09-24
申请号：US13322943
申请日：2010-05-28
摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
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5.发明申请Method and Apparatus for Modular Power Management and Protection of Critical Services in Ambulatory Medical Devices 有权用于模块化电源管理和移动医疗设备中关键服务保护的方法和装置公开(公告)号：US20140215239A1
公开(公告)日：2014-07-31
申请号：US14128811
申请日：2012-06-22
IPC分类号： G06F1/32
CPC分类号： G06F1/3212 , G06F1/3206 , G06F1/3234 , G06F1/3287 , G06F1/329 , G06F9/34 , G16H40/63 , H02J1/14 , H02J3/14 , H02J2007/004 , H04W52/0251 , H04W52/0264 , Y02D70/00
摘要： Architecture and associated methods are provided for power management of ambulatory medical devices. The medical devices is described by a suite of services, each assigned a level of priority (from discretionary to critical), and the power management architecture allows use interchangeable control modules of various levels. A Power Safety Controller supervises the system to ensure appropriate preservation of critical services and provide warnings for low battery level. A Fidelity Controller ensures optimal allocation of power between the different services. A device supervision module estimates device characteristics which can be used by the other levels. The overall architecture ensures a safe and optimal management of services, and allows for a bottom-up deployment of the device.
摘要翻译： 提供了结构和相关方法，用于动态医疗设备的电源管理。 医疗设备由一套服务描述，每个服务分配一个优先级（从任意到关键），电源管理架构允许使用各种级别的可互换控制模块。 电力安全控制器监督系统，以确保关键服务的适当保存，并提供低电量级别的警告。 保真度控制器确保不同服务之间的最佳功率分配。 设备监控模块估计可由其他级别使用的设备特性。 整体架构确保了服务的安全和最佳管理，并允许自下而上的部署设备。
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6.发明申请Method and System For The Safety, Analysis and Supervision of Insulin Pump Action and Other Modes of Insulin Delivery in Diabetes 审中-公开胰岛素泵作用及其他胰岛素输送方式在糖尿病中的安全，分析和监督方法与系统公开(公告)号：US20130116649A1
公开(公告)日：2013-05-09
申请号：US13634040
申请日：2011-03-11
IPC分类号： A61M5/168
CPC分类号： A61M5/1684 , A61M5/16836 , G01N33/74 , G01N2333/62 , G01N2800/042 , G06F19/3468
摘要： An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.
摘要翻译： 具有安全性分析和监督功能的胰岛素递送主管（IDS），其可以位于胰岛素需求和胰岛素递送之间，并且可以在胰岛素递送之前截获任何过量的胰岛素请求。 IDS可以在基于胰岛素泵或笔的任何系统中实现，并且可以使用SMBG或CGM模式的血糖监测。
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7.发明授权CGM-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction of insulin delivery 有权通过低血糖风险评估和平滑减少胰岛素输送，基于CGM预防低血糖公开(公告)号：US08562587B2
公开(公告)日：2013-10-22
申请号：US13203469
申请日：2010-02-25
IPC分类号： A61M31/00
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/4839 , A61B5/7275 , A61B5/746 , A61M5/1723 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3468 , G16H40/63 , G16H50/50
摘要： An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
摘要翻译： 本发明的实施方案或部分实施方案的一个方面（或本发明的全部或部分中的各种实施方案的组合）包括但不限于此，用于连续评估所述方法和系统（以及相关的计算机程序产品） 患者出现低血糖风险，然后根据风险评估确定采取什么行动。 进一步的实施例产生两个输出：（1）应用于发送到泵的胰岛素速率指令的衰减因子（通过常规治疗或经由开环或闭环控制）和/或（2）红/黄/ 绿灯低血糖警报为患者提供低血糖风险的指示。 CPHS的两个输出可以组合使用或单独使用。
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8.发明申请System Coordinator and Modular Architecture for Open-Loop and Closed-Loop Control of Diabetes 有权糖尿病开环和闭环控制的系统协调器和模块化架构公开(公告)号：US20120078067A1
公开(公告)日：2012-03-29
申请号：US13322943
申请日：2010-05-28
摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
摘要翻译： 用于糖尿病控制系统的结构，方法和计算机程序产品提供但不限于以下：适应个体生理特征和适应每个人的行为特征的糖尿病的开环或闭环控制。 这种适应性的一个示例性方面是生物系统（患者或受试者）观察和模块化控制。 因此，建立了模块化系统的基本架构和主要组件，其中可能包括患者行为和代谢状态的算法观察者，以及负责基础速率，胰岛素注射和低血糖预防的相互作用的控制模块。
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9.发明申请CGM-Based Prevention of Hypoglycemia Via Hypoglycemia Risk Assessment and Smooth Reduction of Insulin Delivery 有权通过低血糖风险评估和胰岛素递送平滑减少的基于CGM的低血糖预防公开(公告)号：US20120059353A1
公开(公告)日：2012-03-08
申请号：US13203469
申请日：2010-02-25
IPC分类号： A61M5/168
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/4839 , A61B5/7275 , A61B5/746 , A61M5/1723 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3468 , G16H40/63 , G16H50/50
摘要： An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
摘要翻译： 本发明的实施方案或部分实施方案的一个方面（或本发明的全部或部分中的各种实施方案的组合）包括但不限于此，用于连续评估所述方法和系统（以及相关的计算机程序产品） 患者出现低血糖风险，然后根据风险评估确定采取什么行动。 进一步的实施例产生两个输出：（1）应用于发送到泵的胰岛素速率指令的衰减因子（通过常规治疗或经由开环或闭环控制）和/或（2）红/黄/ 绿灯低血糖警报为患者提供低血糖风险的指示。 CPHS的两个输出可以组合使用或单独使用。
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10.发明授权Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors 有权方法，系统和计算机程序产品，用于实时检测分析物传感器的灵敏度下降公开(公告)号：US08135548B2
公开(公告)日：2012-03-13
申请号：US11925689
申请日：2007-10-26
IPC分类号： G06F17/18
CPC分类号： H04B17/00 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/0223 , G06F19/3418 , G16H40/67
摘要： A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the determined probability exceeds a predetermined threshold level, and generating a first output signal associated with the verification of the presence of signal attenuation is provided. Also provided are systems and kits.
摘要翻译： 一种用于接收多个分析物传感器相关信号的计算机实现的方法，确定与所接收的多个分析物传感器相关信号相关联的信号衰减的概率，当确定的概率超过预定阈值水平时验证信号衰减的存在，以及生成 提供了与验证信号衰减的存在相关联的第一输出信号。 还提供系统和工具包。
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