摘要:
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.
摘要:
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.
摘要:
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译:公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。
摘要:
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO: 2 or SEQ ID NO: 4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译:公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。
摘要:
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive. The linker polypeptide consists of from 11–40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译:公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。
摘要:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.