MATERIALS AND METHODS FOR PREPARING DIMERIC GROWTH FACTORS
    3.
    发明申请
    MATERIALS AND METHODS FOR PREPARING DIMERIC GROWTH FACTORS 审中-公开
    制备二元生长因子的材料与方法

    公开(公告)号:US20090280562A1

    公开(公告)日:2009-11-12

    申请号:US12494050

    申请日:2009-06-29

    IPC分类号: C12N15/63 C12N5/10

    摘要: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

    摘要翻译: 公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。

    Materials and methods for preparing dimeric growth factors
    4.
    发明授权
    Materials and methods for preparing dimeric growth factors 失效
    制备二聚生长因子的材料和方法

    公开(公告)号:US07556941B2

    公开(公告)日:2009-07-07

    申请号:US11550155

    申请日:2006-10-17

    摘要: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO: 2 or SEQ ID NO: 4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

    摘要翻译: 公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。

    Materials and methods for preparing dimeric growth factors
    5.
    发明授权
    Materials and methods for preparing dimeric growth factors 失效
    制备二聚生长因子的材料和方法

    公开(公告)号:US07241593B2

    公开(公告)日:2007-07-10

    申请号:US10365095

    申请日:2003-02-11

    IPC分类号: C12P21/04 C07K14/49

    摘要: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive. The linker polypeptide consists of from 11–40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

    摘要翻译: 公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。