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    Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV)
    2.
    发明授权
    Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) 有权
    使用重组减毒副流感病毒（PIV）作为载体，以防止由PIV和呼吸道合胞病毒（RSV）引起的疾病

    公开(公告)号：US07314631B1

    公开(公告)日：2008-01-01

    申请号：US09458813

    申请日：1999-12-10

    申请人： Brian R. Murphy ,  Peter L. Collins ,  Anna P. Durbin ,  Mario H. Skiadopoulos ,  Tao Tao

    发明人： Brian R. Murphy ,  Peter L. Collins ,  Anna P. Durbin ,  Mario H. Skiadopoulos ,  Tao Tao

    IPC分类号： A61K39/155 ,  C12N7/00

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/155 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/18422 ,  C12N2760/18434 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2760/18734

    摘要： Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These chimeric viruses are infectious and attenuated in humans and other mammals and are useful in vaccine formulations for eliciting and immune responses against one or more PIVs, or against a PIV and non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete PIV vector genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) encoding antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. In preferred aspects of the invention, chimeric PIV incorporate a partial or complete human PIV vector genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a heterologous PIV or non-PIV pathogen, wherein the chimeric virus is attenuated for use as a vaccine agent by any of a variety of mutations and nucleotide modifications introduced into the chimeric genome or antigenome.

    摘要翻译： 提供了嵌合副流感病毒（PIV），其包含PIV载体基因组或反义基因组以及异源PIV或非PIV病原体的一个或多个抗原决定簇。 这些嵌合病毒在人类和其他哺乳动物中是感染性和减毒性的，并且可用于针对一种或多种PIV或针对PIV和非PIV病原体的引发和免疫应答的疫苗制剂。 还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或抗原组的载体，其包括与编码抗原决定簇的一个或多个异源基因或基因组片段组合或整合的部分或完整PIV载体基因组或反义基因， 的异源PIV或非PIV病原体。 在本发明的优选方面，嵌合PIV掺入与来自异源PIV或非PIV病原体的一个或多个异源基因或基因组片段组合的部分或完整的人PIV载体基因组或反向异构体，其中所述嵌合病毒 通过引入到嵌合基因组或反基因组中的各种突变和核苷酸修饰中的任一种减毒用作疫苗剂。

    Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein
    4.
    发明授权
    Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein 有权
    构建和使用表达嵌合糖蛋白的重组副流感病毒

    公开(公告)号：US07250171B1

    公开(公告)日：2007-07-31

    申请号：US09459062

    申请日：1999-12-10

    申请人： Tao Tao ,  Mario H. Skiadopoulos ,  Peter L. Collins ,  Brian R. Murphy

    发明人： Tao Tao ,  Mario H. Skiadopoulos ,  Peter L. Collins ,  Brian R. Murphy

    IPC分类号： A61K31/155 ,  C12N15/00

    CPC分类号： C12N15/86 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N2760/18643

    摘要： Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome modified to encode a chimeric glycoprotein incorporating one or more heterologous antigenic domains, fragments, or epitopes of a second, antigenically distinct HPIV. These chimeric viruses are infectious and attenuated in humans and other mammals and are useful in vaccine formulations for eliciting an immune responses against one or more PIVs, and, optionally against respiratory syncytial virus (RSV). Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a HPIV vector genome or antigenome combined or integrated with one or more heterologous genome segment(s) encoding one or more antigenic determinant(s) of a heterologous PIV to encode a chimeric glycoprotein. In preferred aspects of the invention, the chimeric virus is attenuated for use as a vaccine agent by additional mutations or nucleotide modifications introduced into the chimeric genome or antigenome.

    摘要翻译： 提供了嵌合副流感病毒（PIV），其包含PIV载体基因组或经修饰的反义基因组，以编码掺入一个或多个异源抗原结构域，片段或第二抗原性不同HPIV表位的嵌合糖蛋白。 这些嵌合病毒在人和其他哺乳动物中是感染性和减毒性的，并且可用于引发针对一种或多种PIV的免疫应答的疫苗制剂，以及任选地抗呼吸道合胞病毒（RSV）。 还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或反基因组的载体，其包括与编码异源PIV的一个或多个抗原决定簇的一个或多个异源基因组片段组合或整合的HPIV载体基因组或抗原子集， 编码嵌合糖蛋白。 在本发明的优选方面，嵌合病毒通过引入到嵌合基因组或反基因组中的附加突变或核苷酸修饰来减毒用作疫苗剂。

    Procatalyst composition with alkoxypropyl ester internal electron donor and polymer from same
    6.
    发明授权
    Procatalyst composition with alkoxypropyl ester internal electron donor and polymer from same 有权
    主催化剂组合物与烷氧基丙酯内电子给体和聚合物相同

    公开(公告)号：US09382343B2

    公开(公告)日：2016-07-05

    申请号：US13996340

    申请日：2011-12-01

    申请人： Linfeng Chen ,  Tak W. Leung ,  Tao Tao

    发明人： Linfeng Chen ,  Tak W. Leung ,  Tao Tao

    IPC分类号： C08F4/76 ,  C08F110/06

    CPC分类号： C08F4/76 ,  C08F110/06 ,  C08F4/651 ,  C08F2500/12 ,  C08F4/6543

    摘要： Disclosed herein are catalyst compositions and polymers, i.e., propylene-based polymers, produced therefrom. The present catalyst compositions include an internal electron donor with an alkoxypropyl ester. The present catalyst compositions improve catalyst selectivity. Propylene-based polymer produced from the present catalyst composition has a melt flow rate greater than 4 g/10 min.

    摘要翻译： 本文公开了催化剂组合物和聚合物，即由其制备的基于丙烯的聚合物。 本催化剂组合物包括具有烷氧基丙基酯的内电子给体。 本催化剂组合物改善催化剂选择性。 由本催化剂组合物制备的基于丙烯的聚合物的熔体流动速率大于4g / 10min。

    Mobile multimedia broadcast transmission system
    7.
    发明授权
    Mobile multimedia broadcast transmission system 失效
    移动多媒体广播传输系统

    公开(公告)号：US08576696B2

    公开(公告)日：2013-11-05

    申请号：US13148242

    申请日：2010-02-01

    申请人： Qihong Ge ,  Dong Bai ,  Tao Tao ,  Qiusheng Wang ,  Wen Chen

    发明人： Qihong Ge ,  Dong Bai ,  Tao Tao ,  Qiusheng Wang ,  Wen Chen

    IPC分类号： H04J11/00

    CPC分类号： H04L5/0007 ,  H04L1/0009 ,  H04L1/0057 ,  H04L1/0065 ,  H04L1/0071 ,  H04L5/0044 ,  H04L5/005 ,  H04L5/0064 ,  H04L27/2607

    摘要： A mobile multimedia broadcast transmission system is provided, which comprises: a Reed-Solomon (RS) coding and byte interleaving unit, a Low Density Parity Check (LDPC) coder, a bit interleaver, a constellation mapping unit, a frequency domain symbol generator, a scrambler, an Inverse Fast Fourier Transform (IFFT) unit, a time domain framing unit, and a transmitter. According to the technical solutions provided in the present invention, the system can provide high-quality mobile multimedia services for users in a 6 MHz operation bandwidth. Furthermore, an optimized selection is performed on RS coding according to the operation bandwidth of the system, thereby selecting an appropriate coding mode according to different channel conditions. Accordingly, the byte interleaver is optimized, such that suitable interleaving parameters can be used to perform byte interleaving. With the technical solutions provided in the present invention, the continuous pilots, the discrete pilots and the digital sub-carriers of the system can be suitably configured and allocated according to the actual bandwidth of the system, thereby suitably configuring the system overhead of the mobile multimedia broadcast transmission system to efficiently utilize spectral resources for data transmission.

    摘要翻译： 提供一种移动多媒体广播传输系统，其包括：里德 - 所罗门（RS）编码和字节交织单元，低密度奇偶校验（LDPC）编码器，比特交织器，星座映射单元，频域符号发生器， 扰频器，快速傅里叶逆变换（IFFT）单元，时域成帧单元和发射机。 根据本发明提供的技术方案，该系统可以为6MHz操作带宽的用户提供高质量的移动多媒体业务。 此外，根据系统的操作带宽对RS编码进行优化选择，从而根据不同的信道条件选择适当的编码模式。 因此，字节交织器被优化，使得适当的交织参数可以用于执行字节交织。 利用本发明提供的技术方案，可以根据系统的实际带宽适当地配置和分配系统的连续导频，离散导频和数字子载波，从而适当地配置移动台的系统开销 多媒体广播传输系统，有效利用频谱资源进行数据传输。

    Method for transmitting control information to instruct receiver
    10.
    发明授权
    Method for transmitting control information to instruct receiver 失效
    用于发送控制信息以指示接收机的方法

    公开(公告)号：US07978593B2

    公开(公告)日：2011-07-12

    申请号：US12310037

    申请日：2006-11-24

    申请人： Fajun Yan ,  Tao Tao ,  Wen Chen ,  Qihong Ge ,  Dong Bai ,  Qinghua Yang

    发明人： Fajun Yan ,  Tao Tao ,  Wen Chen ,  Qihong Ge ,  Dong Bai ,  Qinghua Yang

    IPC分类号： H04J11/00

    CPC分类号： H04L5/0094 ,  H04L5/0007

    摘要： A method for transmitting control information to indicate a receiver, comprising following steps: the control information is formed at transmitting side and is encoded based on the working status of the transmitting side of the system; after the encoded control information is mapped, it is multiplexed with other pilot symbol and service load, then an OFDM symbol is generated; the OFDM symbol is transformed from frequency domain to time domain, then a time domain sampling signal is obtained and transmitted to the receiving side of the system; at the receiving side, the time domain sampling signal transmitted by the transmitting side is received and transformed from time domain to frequency domain to form OFDM symbol; the control information is obtained from the valid sub carrier of the OFDM symbol, and the control information is decoded; each work information is extracted form the decoded control information, and the receiving terminal is indicated to execute respective receive process based on the extracted work information. The method can ensure the receiving terminal to receive data based on its own expectation, then reduces the work power consumption of the receiving terminal, and saves the run cost of the digital broadcast system.

    摘要翻译： 一种用于发送控制信息以指示接收机的方法，包括以下步骤：控制信息形成在发送侧，并根据系统的发送侧的工作状态进行编码; 编码控制信息映射后，与其他导频符号和业务负载进行复用，生成OFDM符号; OFDM符号从频域变换为时域，得到时域采样信号并将其发送到系统的接收端; 在接收侧，从发送侧发送的时域采样信号从时域到频域被接收并变换为OFDM符号; 从OFDM符号的有效子载波获得控制信息，对该控制信息进行解码; 从解码控制信息中提取每个工作信息，并且基于所提取的工作信息指示接收终端执行相应的接收处理。 该方法可以确保接收终端根据自己的期望接收数据，降低接收终端的工作功耗，节省数字广播系统的运行成本。