Animal model with disrupted FGF-9 gene
    5.
    发明授权
    Animal model with disrupted FGF-9 gene 失效
    具有破坏的FGF-9基因的动物模型

    公开(公告)号:US6136040A

    公开(公告)日:2000-10-24

    申请号:US256546

    申请日:1999-02-24

    摘要: A unique animal model is disclosed which is useful for studying the role of FGF-9 activity in cardiovascular diseases. To provide this animal model, the FGF-9 gene is disrupted in mice, that is, null mutation in the mouse FGF-9 gene is engineered. This knockout mouse was produced by deleting the sequences immediately downstream of the initiation methionine in exon 1. Analysis of the FGF-9 null embryos demonstrates perinatal lethality with apparent pathology in lung and cardiac tissue.

    摘要翻译: 公开了一种独特的动物模型,可用于研究FGF-9活性在心血管疾病中的作用。 为了提供这种动物模型,FGF-9基因在小鼠中被破坏,即小鼠FGF-9基因中的无效突变是被工程化的。 通过删除外显子1中起始甲硫氨酸的紧邻下游的序列产生该敲除小鼠.FGF-9无效胚胎的分析显示在肺和心脏组织中具有明显病理学的围产期致死性。