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公开(公告)号：US5939262A
公开(公告)日：1999-08-17
申请号：US881571
申请日：1997-06-24
IPC分类号： C12N15/09 , C07K14/01 , C12N7/04 , C12N15/10 , C12N15/40 , C12N15/86 , C12N15/88 , C12P19/34 , C12Q1/68 , C12Q1/70 , C07H21/04 , C12N7/00 , C12N15/63
CPC分类号： C12N7/00 , C07K14/005 , C12N15/10 , C12N15/86 , C12N15/88 , C12P19/34 , C12Q1/6851 , C12Q1/702 , C12Q1/706 , C12Q1/707 , C12N2740/16022 , C12N2740/16062 , C12N2740/16222 , C12N2770/00022 , C12N2770/00023 , C12N2770/00042 , C12N2770/34022 , C12N2770/34023 , C12N2770/34042 , C12N2770/36123 , C12N2770/36143 , C12N2795/10122 , C12N2795/10142 , C12N2795/18122 , C12N2795/18123 , C12Q2600/158
摘要： The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
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公开(公告)号：US06214982B1
公开(公告)日：2001-04-10
申请号：US09282054
申请日：1999-03-30
IPC分类号： C07H2104
CPC分类号： C12N7/00 , C07K14/005 , C12N15/10 , C12N15/86 , C12N15/88 , C12N2740/16022 , C12N2740/16062 , C12N2740/16222 , C12N2770/00022 , C12N2770/00023 , C12N2770/00042 , C12N2770/34022 , C12N2770/34023 , C12N2770/34042 , C12N2770/36123 , C12N2770/36143 , C12N2795/10122 , C12N2795/10142 , C12N2795/18122 , C12N2795/18123 , C12P19/34 , C12Q1/6851 , C12Q1/702 , C12Q1/706 , C12Q1/707 , C12Q2600/158 , C12Q2545/113
摘要： The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
摘要翻译： 本发明一般涉及核酸酶抗性核酸，特别涉及核糖核酸酶抗性RNA。 公开了制备和使用这种核酸的方法。
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公开(公告)号：US20060257889A1
公开(公告)日：2006-11-16
申请号：US11316340
申请日：2005-12-21
申请人： Brittan Pasloske , Dwight DuBois , David Brown , Matthew Winkler
发明人： Brittan Pasloske , Dwight DuBois , David Brown , Matthew Winkler
IPC分类号： C12Q1/68
CPC分类号： C12N7/00 , C07K14/005 , C12N15/10 , C12N15/86 , C12N15/88 , C12N2740/16022 , C12N2740/16062 , C12N2740/16222 , C12N2770/00022 , C12N2770/00023 , C12N2770/00042 , C12N2770/34022 , C12N2770/34023 , C12N2770/34042 , C12N2770/36123 , C12N2770/36143 , C12N2795/10122 , C12N2795/10142 , C12N2795/18122 , C12N2795/18123 , C12P19/34 , C12Q1/6851 , C12Q1/702 , C12Q1/706 , C12Q1/707 , C12Q2600/158 , C12Q2545/113
摘要： The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
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公开(公告)号：US08524680B2
公开(公告)日：2013-09-03
申请号：US12550625
申请日：2009-08-31
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/53 , C12N2320/50 , C12Y102/01012
摘要： The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
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公开(公告)号：US06365731B1
公开(公告)日：2002-04-02
申请号：US08907195
申请日：1997-08-06
申请人： David Brown , Matthew Winkler
发明人： David Brown , Matthew Winkler
IPC分类号： C07H2100
CPC分类号： C12Q1/6834 , Y10S435/975 , C12Q2523/107
摘要： The present invention is directed to compositions and methods for removal of nucleic acid probes from sample nucleic acids, particularly when the sample nucleic acids are attached to a solid support. The invention also concerns methods of stripping and reusing nucleic acid blots.
摘要翻译： 本发明涉及从样品核酸中去除核酸探针的组合物和方法，特别是当样品核酸连接到固体支持物上时。 本发明还涉及剥离和重复使用核酸印迹的方法。
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公开(公告)号：US20080274458A1
公开(公告)日：2008-11-06
申请号：US11743036
申请日：2007-05-01
申请人： Gary J. Latham , Heidi J. Peltier , Jon Kemppainen , Timothy S. Davison , Emmanuel Labourier , David Brown , Matthew Winkler
发明人： Gary J. Latham , Heidi J. Peltier , Jon Kemppainen , Timothy S. Davison , Emmanuel Labourier , David Brown , Matthew Winkler
CPC分类号： C12Q1/6851 , Y10T436/143333 , C12Q2545/107
摘要： The invention relates to a method of determining the amount of a target nucleic acid sequence in a sample, the method comprising: obtaining multiple distinguishable amplicons of the target nucleic acid sequence, each comprising a distinguishing tag and a target portion; amplifying the amplicons in a single reaction volume; and detecting nucleic acids amplified from the amplicons. Detection of the distinguishable amplicons can be varied in each of the steps of the method, which expands the dynamic range of the nucleic acid quantification methods and improves the reliability and accuracy of the methods.
摘要翻译： 本发明涉及一种测定样品中靶核酸序列量的方法，所述方法包括：获得靶核酸序列的多个可区分扩增子，每个扩增子包含鉴别标签和目标部分; 在单个反应体积中扩增扩增子; 并检测从扩增子扩增的核酸。 可区分扩增子的检测可以在该方法的每个步骤中变化，这扩大了核酸定量方法的动态范围，并提高了方法的可靠性和准确性。
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公开(公告)号：US06891032B2
公开(公告)日：2005-05-10
申请号：US10082254
申请日：2002-02-25
申请人： David Brown , Matthew Winkler
发明人： David Brown , Matthew Winkler
CPC分类号： C12Q1/6834 , Y10S435/975 , C12Q2523/107
摘要： The present invention is directed to compositions and methods for removal of nucleic acid probes from sample nucleic acids, particularly when the sample nucleic acids are attached to a solid support. The invention also concerns methods of stripping and reusing nucleic acid blots.
摘要翻译： 本发明涉及从样品核酸中去除核酸探针的组合物和方法，特别是当样品核酸连接到固体支持物上时。 本发明还涉及剥离和重复使用核酸印迹的方法。
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![Pyridine [3,4-b] Pyrazinones](/abs-image/US/2007/10/25/US20070249615A1/abs.jpg.150x150.jpg)
公开(公告)号：US20070249615A1
公开(公告)日：2007-10-25
申请号：US11737966
申请日：2007-04-20
申请人： Robert Hughes , Andrew Bell , David Brown , Dafydd Owen , Michael Palmer , Christopher Phillips , David Brown , Yvette Fobian , John Freskos , Steven Heasley , E. Jacobsen , Todd Maddux , Brent Mischke , John Molyneaux , Joseph Moon , D. Rogier , Michael Tollefson , John Walker
发明人： Robert Hughes , Andrew Bell , David Brown , Dafydd Owen , Michael Palmer , Christopher Phillips , David Brown , Yvette Fobian , John Freskos , Steven Heasley , E. Jacobsen , Todd Maddux , Brent Mischke , John Molyneaux , Joseph Moon , D. Rogier , Michael Tollefson , John Walker
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D471/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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公开(公告)号：US11345606B2
公开(公告)日：2022-05-31
申请号：US15435318
申请日：2017-02-17
申请人： David Brown
发明人： David Brown
IPC分类号： G02B6/02 , C01G23/053 , C01G49/06 , C01B33/18
摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or mandrel.
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公开(公告)号：USD819777S1
公开(公告)日：2018-06-05
申请号：US29581051
申请日：2016-10-14
申请人： David Brown
设计人： David Brown
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