公开(公告)号：US5262229A

公开(公告)日：1993-11-16

申请号：US787372

申请日：1991-11-04

申请人： Bruce G. Lampert ,  William Klein

发明人： Bruce G. Lampert ,  William Klein

IPC分类号： C09J133/08 ,  D04H1/42 ,  H01B1/20 ,  H01B1/24 ,  H05K3/32 ,  C09J9/02

CPC分类号： H01B1/24 ,  C09J133/08 ,  D04H1/4242 ,  D04H1/4291 ,  D04H1/4334 ,  D04H1/4382 ,  H01B1/20 ,  H05K3/321 ,  Y10S428/922 ,  Y10T428/2804 ,  Y10T428/2857

摘要： A conductive releasable adhesive and method of making same for electrostatic discharge controlled surfaces in which a multiplicity of interlacing electrically conductive fibers is suspended in a releasable adhesional substance forming a conductive matrix throughout the volume of the adhesional substance for facilitating dissipation of electrical charges.

摘要翻译： 一种导电性可释放粘合剂及其制造方法，用于静电放电控制表面，其中多个交织导电纤维悬浮在形成导电基质的可释放粘合物质的整个体积的粘附物质中，以便于消耗电荷。

公开(公告)号：US20060166275A1

公开(公告)日：2006-07-27

申请号：US11130566

申请日：2005-05-16

申请人： Grant Krafft ,  William Klein ,  Brett Chromy ,  Mary Lambert ,  Caleb Finch ,  Todd Morgan ,  Pat Wals ,  Irina Rozovsky ,  Ann Barlow

发明人： Grant Krafft ,  William Klein ,  Brett Chromy ,  Mary Lambert ,  Caleb Finch ,  Todd Morgan ,  Pat Wals ,  Irina Rozovsky ,  Ann Barlow

IPC分类号： A61K38/17 ,  C07K14/47 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/4711 ,  A61K38/00

摘要： The invention described in this disclosure involves a new composition of matter, amyloid beta-derived dementing ligands (ADDL's). ADDLs consist of amyloid β peptide assembled into soluble globular non-fibrillar oligomeric structures that are capable of activating specific cellular processes. The invention further encompasses methods for assaying the formation, presence, receptor protein binding and cellular activities of ADDLs. The invention further encompasses assay methods and inhibitor molecules for cellular signaling molecules activated by ADDLs. Also described are molecules that block proteins that promote the formation of ADDLs.

公开(公告)号：US20070213512A1

公开(公告)日：2007-09-13

申请号：US11686570

申请日：2007-03-15

申请人： Grant Krafft ,  William Klein ,  Kirsten Viola ,  Mary Lambert ,  Todd Pray ,  Ray Lowe

发明人： Grant Krafft ,  William Klein ,  Kirsten Viola ,  Mary Lambert ,  Todd Pray ,  Ray Lowe

IPC分类号： C07K14/00

CPC分类号： C07K14/4711 ,  A61K39/0007 ,  C07K16/18

摘要： The present invention provides amyloid β peptide assemblies composed of at least three amyloid β peptide subunits, wherein at least one of the amyloid β peptide subunits is an amyloid β peptide analog. The invention further relates to metal complexes of amyloid β peptide assemblies and the use of amyloid β peptide assemblies as vaccines and in the identification of agents that modulate assembly of the amyloid β peptide subunits.

摘要翻译： 本发明提供了由至少三个淀粉样蛋白β肽亚基组成的淀粉样蛋白β肽组件，其中淀粉样蛋白β肽亚基中的至少一个是淀粉样蛋白β肽类似物。 本发明还涉及淀粉样蛋白β肽组件的金属络合物和淀粉样蛋白β肽组件作为疫苗的用途，以及用于鉴定调节淀粉状蛋白β肽亚基的组装的试剂。

公开(公告)号：US20060071422A1

公开(公告)日：2006-04-06

申请号：US10916351

申请日：2004-08-11

申请人： William Klein ,  Bhaskar Ramakrishnan

发明人： William Klein ,  Bhaskar Ramakrishnan

IPC分类号： B65H5/02

CPC分类号： B65H5/062 ,  B65H2401/23 ,  B65H2402/31 ,  B65H2402/54 ,  B65H2404/143

摘要： Printer (1) feeds paper or other media sheets (5) to pinch rollers (9a, 9b), which further feed the sheets into an imaging station (7). Pressure rollers (9b) are held by plate 22 which is biased by a spring (33) and pivots on extensions (37a, 37) to moves pressure rollers (9b) into nip relationship with nip roller (9a). To evenly distribute the forces across pressure rollers (9b), plate 22 is weakened by depressed lines (27a, 27b) located between the spring and the pressure rollers (9b).

摘要翻译： 打印机（1）将纸张或其他介质片（5）送入夹送辊（9a，9b），进一步将片材进给到成像站（7）中。 压力辊（9b）由板22保持，板22由弹簧33偏压并在延伸部37a上移动，以使压力辊9a与夹持辊9a相啮合。 为了将力均匀地分布在压力辊（9b）之间，板22被位于弹簧和压力辊（9b）之间的凹陷线（27a，27b）减弱。

公开(公告)号：US20050275150A1

公开(公告)日：2005-12-15

申请号：US10865632

申请日：2004-06-10

申请人： Brian Cook ,  William Klein

发明人： Brian Cook ,  William Klein

IPC分类号： B41J13/00 ,  B65H3/06 ,  B65H5/06 ,  B65H7/02 ,  F16H61/16 ,  F16H61/18

CPC分类号： B41J13/0018 ,  B65H3/0676 ,  B65H5/06 ,  B65H7/02 ,  B65H2403/40 ,  B65H2404/1441 ,  B65H2404/16 ,  B65H2511/11 ,  B65H2511/51 ,  B65H2515/32 ,  B65H2220/01 ,  B65H2220/02

摘要： Printer (1) has a pivotally mounted autocompensating system (19) mounted at an intermediate position in paper guide (17). That system (19) is driven by a motor (40) through a slip drive (70, 72, 74). The motor also drives paper feed system (15). When the motor turns in a direction to feed by system (15), the intermediate system is moved away from the paper guide. When a sheet reaches a position to be fed by the intermediate system, the motor is reversed, and the intermediate system pivots against the paper for moving it further through the paper guide.

摘要翻译： 打印机（1）具有安装在纸张引导件（17）中的中间位置的可枢转地安装的自动补偿系统（19）。 该系统（19）由马达（40）通过滑动驱动（70,72,74）驱动。 电机还驱动送纸系统（15）。 当电机沿着由系统（15）馈送的方向转动时，中间系统从导纸器移开。 当纸张到达要由中间系统供给的位置时，电动机反转，并且中间系统抵靠纸张枢转，以使其进一步移动通过纸张引导件。

公开(公告)号：US20070218499A1

公开(公告)日：2007-09-20

申请号：US11571532

申请日：2005-07-05

申请人： Mary Lambert ,  Pauline Velasco ,  Lei Chang ,  Kirsten Viola ,  Sara Fernandez ,  Pascale Lacor ,  Daliya Khuon ,  Yuesong Gong ,  William Klein ,  Grant Krafft

发明人： Mary Lambert ,  Pauline Velasco ,  Lei Chang ,  Kirsten Viola ,  Sara Fernandez ,  Pascale Lacor ,  Daliya Khuon ,  Yuesong Gong ,  William Klein ,  Grant Krafft

IPC分类号： G01N33/53 ,  C07K16/18

CPC分类号： C07K16/18 ,  C07K2317/76 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.

摘要翻译： 本文公开了与淀粉样蛋白β（Abeta）的可溶性低聚物以高特异性结合的抗体以及使用这些抗体的方法。 抗体能够区分阿尔茨海默病（AD）和对照人脑提取物。 抗体鉴定AD脑切片中的内源性Aβ寡聚物，并且还结合培养的海马细胞上的Abeta寡聚物。 抗体中和溶液中产生的内源性Aβ低聚物和Abeta寡聚体。

公开(公告)号：US20070048312A1

公开(公告)日：2007-03-01

申请号：US11496149

申请日：2006-07-31

申请人： William Klein ,  Grant Krafft ,  Mary Lambert ,  Kirsten Viola ,  Brett Chromy ,  Lei Chang

发明人： William Klein ,  Grant Krafft ,  Mary Lambert ,  Kirsten Viola ,  Brett Chromy ,  Lei Chang

IPC分类号： A61K39/395

CPC分类号： G01N33/6896 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4711 ,  C07K16/18 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes.

摘要翻译： 本发明包括结合淀粉样蛋白β衍生的扩散配体（ADDL）的抗体。 ADDL包含组装成能够激活特异性细胞过程的可溶性，球状，非纤维状，寡聚结构的淀粉样蛋白β蛋白。

公开(公告)号：US20060226592A1

公开(公告)日：2006-10-12

申请号：US11092472

申请日：2005-03-29

申请人： William Klein

发明人： William Klein

IPC分类号： B65H3/06

CPC分类号： B65H3/0661 ,  B65H2402/31 ,  B65H2404/1521 ,  B65H2405/114

摘要： A media feeding apparatus includes a side wall, the side wall having a first side surface and an opposite side surface. A sheet picking mechanism has a pick arm and a pick roller. The pick arm is configured to mount the pick roller. The pick arm has a pivot axis substantially perpendicular to the side wall. A restraint is mounted to the pick arm, wherein at least the first side surface of the side wall is in close proximity to the restraint.

摘要翻译： 介质供给装置包括侧壁，侧壁具有第一侧表面和相对的侧表面。 片材拾取机构具有拾取臂和拾取辊。 拾取臂配置为安装拾纸辊。 拾取臂具有基本上垂直于侧壁的枢转轴线。 约束被安装到拾取臂，其中至少侧壁的第一侧表面紧邻约束。

公开(公告)号：US20060071391A1

公开(公告)日：2006-04-06

申请号：US10930446

申请日：2004-08-31

申请人： Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

发明人： Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

IPC分类号： B65H5/00 ,  B65H7/02

CPC分类号： B65H7/02 ,  B65H2402/54 ,  B65H2403/72 ,  B65H2511/51 ,  B65H2553/81

摘要： An imaging apparatus includes a printing mechanism having a media path. A print media source is provided for supplying a sheet of print media to the printing mechanism. A drive unit is provided, with a drive shaft coupled to the drive unit. A media sensor device is mounted to the drive shaft, wherein as the drive shaft is rotated in a first direction the media sensor device is moved from a first position that is out of the media path to a second position that is in the media path for sensing the sheet of print media. As the drive shaft is rotated in a second direction opposite to the first direction the media sensor device is moved from the second position that is in the media path for sensing the sheet of print media to the first position that is out of the media path.

摘要翻译： 成像装置包括具有媒体路径的打印机构。 提供了一种打印介质源，用于将一张打印介质供给到打印机构。 提供了一个驱动单元，其中驱动轴联接到驱动单元。 介质传感器装置安装到驱动轴上，其中当驱动轴沿第一方向旋转时，介质传感器装置从介质路径外的第一位置移动到位于介质路径中的第二位置 感测印张介质。 当驱动轴沿与第一方向相反的第二方向旋转时，介质传感器装置从用于感测印张介质的介质路径的第二位置移动到介质路径外的第一位置。

公开(公告)号：US08383113B2

公开(公告)日：2013-02-26

申请号：US13368742

申请日：2012-02-08

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/5058 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。