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    COMPOSITION AND METHODS FOR THE PREVENTION AND TREATMENT OF MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND DIABETIC MACULAR EDEMA
    4.
    发明申请
    COMPOSITION AND METHODS FOR THE PREVENTION AND TREATMENT OF MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND DIABETIC MACULAR EDEMA 审中-公开
    用于预防和治疗谷氨酸减少症，糖尿病性肾病和糖尿病肾病的组合物和方法

    公开(公告)号：US20130045926A1

    公开(公告)日：2013-02-21

    申请号：US13512972

    申请日：2010-12-03

    申请人： Dale P. Devore ,  Bruce H. Dewoolfson ,  Vance Thompson

    发明人： Dale P. Devore ,  Bruce H. Dewoolfson ,  Vance Thompson

    IPC分类号： A61K38/17 ,  A61P27/02

    CPC分类号： A61K38/1709

    摘要： Methods of stabilizing and organizing collagen fibrils in extracellular matrix of retinal tissues, particularly Bruch's membranes, and stabilizing retinal pigment epithelial layers lining Bruch's membrane are disclosed. The stabilization and organization may be effected by treating retinal tissues with a protein that crosslinks and organizes collagen fibrils, such as decorin. The stabilization and organization methods include treatment of retinal tissues before, during, or after diagnosis of dry macular degeneration, diagnosis of early stages of diabetic retinopathy and diabetic macular edema to prevent, retard, or limit progression of disorganization of Bruch's membrane and disorganization of retinal pigment epithelial cells lining Bruch's membrane.

    摘要翻译： 公开了稳定和组织视网膜组织的细胞外基质中的胶原纤维的方法，特别是Bruch膜，并稳定了布鲁赫膜上的视网膜色素上皮层。 稳定和组织可以通过用交联和组织胶原原纤维（例如核心蛋白聚糖）的蛋白质处理视网膜组织来实现。 稳定化和组织方法包括在干性黄斑变性诊断之前，期间或之后治疗视网膜组织，诊断糖尿病性视网膜病变的早期阶段和糖尿病性黄斑水肿，以预防，延缓或限制Bruch's膜的组织进展和视网膜组织紊乱 色素上皮细胞衬里布鲁赫膜。

    Collagen modulators for use in photoablation eximer laser keratectomy
    5.
    发明授权
    Collagen modulators for use in photoablation eximer laser keratectomy 失效
    用于光消融预处理激光角膜切除术的胶原调节剂

    公开(公告)号：US5861486A

    公开(公告)日：1999-01-19

    申请号：US602922

    申请日：1996-02-16

    申请人： Dale P. Devore ,  Richard A. Eiferman

    发明人： Dale P. Devore ,  Richard A. Eiferman

    IPC分类号： A61F9/008 ,  A61F9/01 ,  A61L26/00 ,  A61L31/04 ,  C07K14/78 ,  C08H1/06 ,  C08L89/06 ,  A61K38/17 ,  A61K38/39

    CPC分类号： C08H1/06 ,  A61F9/00819 ,  A61L26/0033 ,  A61L31/044 ,  C07K14/78 ,  C08L89/06 ,  A61F2009/00872 ,  A61F9/00804

    摘要： A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.

    摘要翻译： 提供了一种通过光烧伤激光角膜切除术来平滑不规则角膜表面和从角膜表面去除突起的方法。 描述了用于制备用于光蚀刻程序的胶原调节剂的胶原组合物。 将这些组合物以足够的量应用于不规则的角膜表面，至少填充角膜表面上的凹陷或其它不规则物，并在光消除之前转化为调制剂，作为凝胶或聚合膜。 胶原调节剂促进不规则角膜表面的光蚀刻平滑，并保护邻近角膜组织免受不希望的光消融。

    Method for preparation of type II collagen
    6.
    发明授权
    Method for preparation of type II collagen 失效
    II型胶原蛋白的制备方法

    公开(公告)号：US5840848A

    公开(公告)日：1998-11-24

    申请号：US778467

    申请日：1997-01-03

    申请人： Anna Gunilla Oberg Sturrock ,  Dale P. Devore

    发明人： Anna Gunilla Oberg Sturrock ,  Dale P. Devore

    IPC分类号： C12P21/06 ,  A61K38/00 ,  C07K14/78 ,  A61K37/17 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00

    CPC分类号： C07K14/78 ,  A61K38/00

    摘要： An method is disclosed for removing Type I collagen-containing tissue adjoining Type II collagen-containing animal tissue comprising treatment of unprocessed Type II collagen-containing tissue in an acidic solution in the presence of an acid proteinase and subjecting the mixture to moderate agitation for a period of time sufficient to cause digestion or separation of the Type I collagen-containing tissue from the Type II collagen-containing tissue. Also disclosed are methods for removing proteoglycans from Type II collagen-containing tissue.

    摘要翻译： 公开了一种用于去除含有II型胶原的动物组织的含I型胶原的组织的方法，包括在酸性蛋白酶存在下在酸性溶液中处理未加工的含II型胶原蛋白的组织，并对该混合物进行适度搅拌 足以引起含有I型胶原的组织从含有I型胶原的组织消化或分离的时间。 还公开了从含II型胶原的组织中去除蛋白聚糖的方法。

    Collagen modulators for use in photoablation eximer laser keratectomy
    7.
    发明授权
    Collagen modulators for use in photoablation eximer laser keratectomy 失效
    用于光消融预处理激光角膜切除术的胶原调节剂

    公开(公告)号：US06204365B1

    公开(公告)日：2001-03-20

    申请号：US09232529

    申请日：1999-01-18

    申请人： Dale P. Devore ,  Richard A. Eiferman

    发明人： Dale P. Devore ,  Richard A. Eiferman

    IPC分类号： A61K3817

    CPC分类号： C08H1/06 ,  A61F9/00804 ,  A61F9/00819 ,  A61F2009/00872 ,  A61L26/0033 ,  A61L31/044 ,  C07K14/78 ,  C08L89/06

    摘要： A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.

    摘要翻译： 提供了一种通过光烧伤激光角膜切除术来平滑不规则角膜表面和从角膜表面去除突起的方法。 描述了用于制备用于光蚀刻程序的胶原调节剂的胶原组合物。 将这些组合物以足够的量应用于不规则的角膜表面，至少填充角膜表面上的凹陷或其它不规则物，并在光消除之前转化为调制剂，作为凝胶或聚合膜。 胶原调节剂促进不规则角膜表面的光蚀刻平滑，并保护邻近角膜组织免受不希望的光消融。

    Methods and products for sealing a fluid leak in a tissue
    8.
    发明授权
    Methods and products for sealing a fluid leak in a tissue 失效
    用于密封组织中的液体泄漏的方法和产品

    公开(公告)号：US06183498B2

    公开(公告)日：2001-02-06

    申请号：US09180687

    申请日：1999-09-20

    申请人： Dale P. Devore ,  Charles Putnam ,  James M. Pachence

    发明人： Dale P. Devore ,  Charles Putnam ,  James M. Pachence

    IPC分类号： A61B1704

    CPC分类号： A61L24/102 ,  A61B17/00491 ,  A61B17/0057 ,  A61B2017/005 ,  A61L24/10 ,  A61L24/104 ,  A61L24/106 ,  A61L24/108

    摘要： Methods and products for rapidly sealing a fluid leak in a tissue are provided. A polymerizable protein is applied to a tissue having an opening which creates a fluid leak in the tissue, in order to seal the opening. The tissue area and opening coated with the polymerizable protein are exposed to an initiator in order to polymerize the covering in situ, and create a seal over the opening that prevents fluid leakage. The methods and products to the invention may be used, for example, to seal airholes in lung injuries and to seal anastomoses and suture lines for blood vessels.

    摘要翻译： 提供了用于快速密封组织中的流体泄漏的方法和产品。 将可聚合蛋白质施加到具有在组织中产生流体泄漏的开口的组织，以便密封开口。 涂覆有可聚合蛋白质的组织区域和开口暴露于引发剂以便原位聚合覆盖物，并且在开口上形成防止流体泄漏的密封。 本发明的方法和产品可用于例如密封肺损伤中的气孔并密封吻合缝合线以用于血管。

    METHODS AND ARTICLES OF MANUFACTURE FOR THE TREATMENT OF SKIN
    10.
    发明申请
    METHODS AND ARTICLES OF MANUFACTURE FOR THE TREATMENT OF SKIN 审中-公开
    用于治疗皮肤的方法和制造方法

    公开(公告)号：US20160038391A1

    公开(公告)日：2016-02-11

    申请号：US14782420

    申请日：2014-04-04

    申请人： Leonard B. MILLER ,  Dale P. DEVORE ,  Advance Collagen Science LLC

    发明人： Leonard B. Miller ,  Dale P. Devore

    IPC分类号： A61K8/49 ,  A61Q19/08

    CPC分类号： A61K8/498 ,  A61K8/35 ,  A61K2800/28 ,  A61K2800/87 ,  A61K2800/882 ,  A61K2800/884 ,  A61K2800/91 ,  A61K2800/94 ,  A61K2800/95 ,  A61Q19/00 ,  A61Q19/08

    摘要： Embodiments of the present invention are directed to methods and articles of manufacture to treat skin to improve and/or increase hydration, pliability, and thickness for improved texture, feel and appearance. Embodiments feature applying an effective amount of an acetylation agent to natural dermal collagen under reaction conditions to react the natural dermal collagen with the acetylation agent to form a modified collagen. The modified collagen has a higher net charge and higher net charge density than natural dermal collagen. The modified collagen improves or increases one or more skin characteristics consisting of hydration, pliability and thickness.

    摘要翻译： 本发明的实施方案涉及用于治疗皮肤以改善和/或增加水合，柔韧性和厚度以提高质地，感觉和外观的方法和制品。 实施例的特征是在天然皮肤胶原蛋白的反应条件下应用有效量的乙酰化剂使天然真皮胶原与乙酰化剂反应形成改良的胶原蛋白。 改性胶原蛋白具有比天然皮肤胶原蛋白更高的净电荷和更高的净电荷密度。 改性胶原蛋白改善或增加由水合，柔韧性和厚度组成的一种或多种皮肤特性。