公开(公告)号：US20060241735A1

公开(公告)日：2006-10-26

申请号：US11115594

申请日：2005-04-26

申请人： Bruce Tockman ,  Scott Stockmoe ,  Eric Johnson ,  John Greenland ,  Gary Hague ,  William Webler

发明人： Bruce Tockman ,  Scott Stockmoe ,  Eric Johnson ,  John Greenland ,  Gary Hague ,  William Webler

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N2001/0585

摘要： The present invention provides a cardiac vascular occlusion system which includes inner and outer guide catheters and an occluding member disposed on the inner catheter. The occluding member may be deployed from a compressed to an expanded position to limit retrograde blood flow in a body lumen. The occluding member may be used when injecting a contrast agent into the body lumen.

摘要翻译： 本发明提供一种心脏血管闭塞系统，其包括内导管和外引导导管以及设置在内导管上的闭塞构件。 闭塞构件可以从压缩展开到展开位置以限制体腔内的逆行血流。 当将造影剂注入体腔时，可以使用闭塞构件。

公开(公告)号：US20070010793A1

公开(公告)日：2007-01-11

申请号：US11159705

申请日：2005-06-23

申请人： Peter Callas ,  Gary Hague ,  John Greenland ,  Bruce Tockman ,  Peter Kelley ,  Jason Shiroff ,  David Yingling ,  Ted Schulte

发明人： Peter Callas ,  Gary Hague ,  John Greenland ,  Bruce Tockman ,  Peter Kelley ,  Jason Shiroff ,  David Yingling ,  Ted Schulte

IPC分类号： A61M31/00

CPC分类号： A61B17/3478 ,  A61B2017/306 ,  A61M25/0084

摘要： A device and method for accessing a pericardial space of the heart includes a shaft having a cavity at a distal end, a suction lumen terminating in a distal port within the cavity and a hollow needle having a distal tip extending into the cavity. The cavity may be a recess in the shaft into which the distal tip of the needle fixedly protrudes. In other embodiments, the cavity is formed by an inflatable member positioned at the distal end of the shaft and the needle is slidable relative to the shaft. Suction is applied at the cavity to draw a pericardial bleb. The needle pierces the pericardial bleb for accessing the pericardial space and also facilitates delivery of payloads into the pericardial space.

摘要翻译： 用于访问心脏心包空间的装置和方法包括：具有在远端处的空腔的轴，位于空腔内的远端端口中的抽吸腔，以及具有延伸到空腔中的远端的中空针。 空腔可以是轴中的凹部，其中针的远侧末端固定地突出。 在其他实施例中，空腔由位于轴的远端处的可充气构件形成，并且针可相对于轴滑动。 在空腔处抽取吸入心包泡。 针刺穿心包泡，用于进入心包空间，并且还有助于将载荷递送到心包空间中。

公开(公告)号：US07526343B2

公开(公告)日：2009-04-28

申请号：US11459587

申请日：2006-07-24

申请人： Charles Peterson ,  John Greenland ,  Gary Hague

发明人： Charles Peterson ,  John Greenland ,  Gary Hague

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： A method of accessing lateral branch veins of the coronary sinus with a pacing lead and guide catheter assembly. The guide catheter has an open lumen extending therethrough and a distal end provided with a pre-formed guide curve, while the pacing lead has a distal end provided with a first curve and a second curve extending proximally from the first curve. The guide catheter is inserted into an access vessel of the heart and advanced along the access vessel to the coronary sinus. The pacing lead is inserted into the guide catheter lumen and advanced distally through the guide catheter lumen. The pacing lead is rotated by advancing the second curve of the pacing lead through the guide curve to align the first curve with a pre-determined plane. The first curve of the pacing lead into one of the lateral branch veins of the coronary sinus.

摘要翻译： 一种采用起搏引导和引导导管组件来获取冠状窦的横向分支静脉的方法。 引导导管具有延伸穿过其中的开口腔和设置有预先形成的引导曲线的远端，而起搏引线具有设置有第一曲线的远端和从第一曲线向近侧延伸的第二曲线。 引导导管被插入到心脏的进入容器中并且沿着进入容器前进到冠状窦。 起搏引线插入引导导管内腔，并通过引导导管腔远端前进。 通过使起搏引线的第二曲线通过引导曲线使起搏引线旋转，以将第一曲线与预定平面对齐。 起搏的第一条曲线导致冠状窦的一个横向分支静脉。

公开(公告)号：US20070129752A1

公开(公告)日：2007-06-07

申请号：US11295419

申请日：2005-12-06

申请人： William Webler ,  Gary Hague ,  Frank Manning

发明人： William Webler ,  Gary Hague ,  Frank Manning

IPC分类号： A61M29/00

CPC分类号： A61M25/10 ,  A61B2017/22067 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61M25/0029 ,  A61M25/0032 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1086

摘要： Catheter or guidewire mounted automatic vessel occlusion and fluid dispersion devices that expand to occlude or partially occlude a vessel when a fluid is flowing in the catheter or guidewire, and that automatically collapse when fluid flow is stopped. Each occlusion device has an elastic skeleton covered with a flexible cover coupled thereto and may have a hole(s) or openings in its distal or proximal end thereof to allow controlled flow through the desired end of the occlusion device. The fluid may be a flush fluid for enabling or improving the performance of imaging devices and image enhancing fluids, of treatment fluids for localized treatment of a vessel or tissues in communication with the vessel and/or of the transmission of energy to the vessel wall and adjacent tissues. Various embodiments are disclosed, including embodiments having provisions for the rapid expansion and collapse of the occlusion device or alternately, for the rapid expansion of the device, followed by much slower collapse of the device.

摘要翻译： 导管或导丝安装的自动血管闭塞和流体分散装置，其在流体在导管或导丝中流动时膨胀以封闭或部分闭塞血管，并且当流体流停止时自动塌陷。 每个闭塞装置具有被耦合到其上的柔性盖子覆盖的弹性框架，并且在其远端或近端具有孔或开口，以允许受阻流过穿过闭塞装置的期望端部。 流体可以是冲洗流体，用于实现或改善成像装置和图像增强流体的性能，用于处理流体用于与容器连通的容器或组织的局部处理和/或向容器壁传递能量， 相邻组织。 公开了各种实施例，包括具有用于闭塞装置的快速膨胀和塌缩的装置的替代实施例，或者替代地，用于装置的快速膨胀，其后是装置的较慢的崩溃。

公开(公告)号：US07542808B1

公开(公告)日：2009-06-02

申请号：US10944303

申请日：2004-09-17

申请人： Charles Peterson ,  John Greenland ,  Gary Hague

发明人： Charles Peterson ,  John Greenland ,  Gary Hague

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： A guide catheter assembly for accessing lateral branch veins of the coronary sinus includes a guide catheter and a pacing lead. The guide catheter has a central lumen therethrough, a proximal end and a distal end pre-formed with a guide curve. The pacing lead is slidably receivable within the guide catheter lumen. The pacing lead has a proximal end and a distal end formed with a first curve and a second curve extending proximally from the first curve. The second curve is adapted to mate with the guide curve to direct the first curve into a selected branch vein of the coronary sinus. The second curve may be pre-formed in the pacing lead, or may be imparted to the pacing lead via a stylet or inner catheter.

摘要翻译： 用于进入冠状窦的横向分支静脉的引导导管组件包括导向导管和起搏引线。 引导导管具有穿过其的中央腔，近端和预先形成有引导曲线的远端。 起搏引线可滑动地接收在引导导管内腔内。 起搏引线具有近端和远端，其形成有第一曲线和从第一曲线向近侧延伸的第二曲线。 第二曲线适于与引导曲线配合，以将第一曲线引导至冠状窦的选定分支静脉。 第二曲线可以在起搏引线中预先形成，或者可以经由探针或内导管施加到起搏引线。

公开(公告)号：US20120302891A1

公开(公告)日：2012-11-29

申请号：US13485826

申请日：2012-05-31

申请人： William E. Webler ,  Gary Hague ,  Frank E. Manning

发明人： William E. Webler ,  Gary Hague ,  Frank E. Manning

IPC分类号： A61M25/10 ,  A61B6/00 ,  A61B8/12 ,  A61M25/09

CPC分类号： A61M25/10 ,  A61B2017/22067 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61M25/0029 ,  A61M25/0032 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1086

摘要： Catheter or guidewire mounted automatic vessel occlusion and fluid dispersion devices that expand to occlude or partially occlude a vessel when a fluid is flowing in the catheter or guidewire, and that automatically collapse when fluid flow is stopped. Each occlusion device has an elastic skeleton covered with a flexible cover coupled thereto and may have a hole(s) or openings in its distal or proximal end thereof to allow controlled flow through the desired end of the occlusion device. The fluid may be a flush fluid for enabling or improving the performance of imaging devices and image enhancing fluids, of treatment fluids for localized treatment of a vessel or tissues in communication with the vessel and/or of the transmission of energy to the vessel wall and adjacent tissues. Various embodiments are disclosed.

摘要翻译： 导管或导丝安装的自动血管闭塞和流体分散装置，其在流体在导管或导丝中流动时膨胀以封闭或部分闭塞血管，并且当流体流停止时自动塌陷。 每个闭塞装置具有被耦合到其上的柔性盖子覆盖的弹性框架，并且在其远端或近端具有孔或开口，以允许受阻流过穿过闭塞装置的期望端部。 流体可以是冲洗流体，用于实现或改善成像装置和图像增强流体的性能，用于处理流体用于与容器连通的容器或组织的局部处理和/或向容器壁传递能量， 相邻组织。 公开了各种实施例。

公开(公告)号：US20120062405A1

公开(公告)日：2012-03-15

申请号：US12924785

申请日：2010-10-05

申请人： Sebastian Loeda ,  Gary Hague

发明人： Sebastian Loeda ,  Gary Hague

IPC分类号： H03M3/00 ,  H04N7/26

CPC分类号： H03M3/37 ,  H03M3/452

摘要： A summing-tracking quantizer additively combines multiple feed-forward outputs of cascaded integrator stages of a sigma-delta analog-to-digital converter with a scaled sampled analog signal, and a delayed scaled analog input signal. The summing tracking quantizer compensates for loop delay within a sigma-delta analog-to-digital converter. A loop delay compensation digital-to-analog converter for a sigma-delta analog-to-digital converter is merged with the voltage reference generator within the summing-tracking quantizer. The summing tracking quantizer selects reference voltages from the voltage reference generator based on a previous digital output code. The summing-tracking quantizer has a matrix switch that receives the previous digital output code and selects the reference voltage for applying to comparators for determining a differential quantization code that is additively combined to the previous digital output code to determine the present digital output code.

摘要翻译： 加和跟踪量化器将Σ-Δ模数转换器的级联积分器级的多个前馈输出与经缩放的采样模拟信号和延迟缩放的模拟输入信号相加地组合。 求和跟踪量化器补偿Σ-Δ模数转换器内的环路延迟。 用于Σ-Δ模数转换器的环路延迟补偿数模转换器与求和跟踪量化器内的电压基准发生器合并。 求和跟踪量化器基于先前的数字输出代码选择来自参考电压源的参考电压。 求和跟踪量化器具有矩阵开关，其接收先前的数字输出代码并选择用于施加到比较器的参考电压，以确定与之前的数字输出代码相加组合的差分量化代码，以确定当前的数字输出代码。

公开(公告)号：US20120139768A1

公开(公告)日：2012-06-07

申请号：US12928867

申请日：2010-12-21

申请人： Sebastian Loeda ,  Gary Hague

发明人： Sebastian Loeda ,  Gary Hague

IPC分类号： H03M3/00

CPC分类号： H03M3/50 ,  H03M3/458 ,  H03M5/08 ,  H03M5/14 ,  H04B14/026

摘要： An audio device (200) includes a first and second ICs (210) and (250) and a substrate (205). The first IC includes a sigma-delta, A/D converter (218) operable to convert an analog signal (234) into a pulse density modulated signal (236). A pulse density width modulator encoder (222) is operable to encode the PDM signal into a PDWM signal (244). The PDWM has short and long pulse widths defining first and second bit levels. The leading edges of each pulse bounds each pulse period. The second IC (250) includes a means (254) to receive the PDWM signal, an edge detector (304) operable to detect the leading pulse edges of the PDWM signal, a time-averaging circuit (308) operable to calculate each pulse period from the leading pulse edges and to generate a sample pulse (120) at near the midpoint of each pulse period, and a latch (312) operable to sample and hold the PDWM signal at the sample pulse to decode a PDM signal (278). The substrate is operable to support the first and second ICs and to conduct the PDWM signal between the first and second ICs.

公开(公告)号：US07091892B2

公开(公告)日：2006-08-15

申请号：US11008367

申请日：2004-12-09

申请人： David Tester ,  Gary Hague ,  Jorg Medwed

发明人： David Tester ,  Gary Hague ,  Jorg Medwed

IPC分类号： H03M1/00

CPC分类号： G05F3/262

摘要： An accurate high current mirror circuit produces a mirrored current that matches an input current to produce an accuracy at the output of a subsequent stage of amplification of greater than 0.01%. A plurality of transistor devices are arranged in a symmetrical configuration and divided into two groups. The transistors in each of the two groups are connected in parallel to produce a high mirror current from a high input current. A distribution of a source voltage produces the same source voltage at each of the plurality of transistors. An input current metallization and a mirror current metallization are formed within the symmetrical configuration to have a same value of impedance. A plurality of P-channel transistors within the current mirror circuit control a voltage of a point on the input metallization to be the same as a reference voltage, thus causing the mirror current to be referenced around the reference voltage.

摘要翻译： 精确的大电流镜电路产生与输入电流匹配的镜像电流，以在后续放大级的输出处产生大于0.01％的精度。 多个晶体管器件被布置成对称配置并分成两组。 两组中的每一个中的晶体管并联连接以从高输入电流产生高反射镜电流。 源极电压的分布在多个晶体管的每一个处产生相同的源极电压。 在对称构造内形成输入电流金属化和反射镜电流金属化以具有相同的阻抗值。 电流镜电路内的多个P沟道晶体管将输入金属化点上的电压控制为与参考电压相同，从而使反射镜电流围绕参考电压进行参考。

公开(公告)号：US08284086B2

公开(公告)日：2012-10-09

申请号：US12928867

申请日：2010-12-21

申请人： Sebastian Loeda ,  Gary Hague

发明人： Sebastian Loeda ,  Gary Hague

IPC分类号： H03M3/00

CPC分类号： H03M3/50 ,  H03M3/458 ,  H03M5/08 ,  H03M5/14 ,  H04B14/026

摘要： An audio device (200) includes a first and second ICs (210) and (250) and a substrate (205). The first IC includes a sigma-delta, A/D converter (218) operable to convert an analog signal (234) into a pulse density modulated signal (236). A pulse density width modulator encoder (222) is operable to encode the PDM signal into a PDWM signal (244). The PDWM has short and long pulse widths defining first and second bit levels. The leading edges of each pulse bounds each pulse period. The second IC (250) includes a means (254) to receive the PDWM signal, an edge detector (304) operable to detect the leading pulse edges of the PDWM signal, a time-averaging circuit (308) operable to calculate each pulse period from the leading pulse edges and to generate a sample pulse (120) at near the midpoint of each pulse period, and a latch (312) operable to sample and hold the PDWM signal at the sample pulse to decode a PDM signal (278). The substrate is operable to support the first and second ICs and to conduct the PDWM signal between the first and second ICs.

摘要翻译： 音频设备（200）包括第一和第二IC（210）和（250）和基板（205）。 第一IC包括可操作以将模拟信号（234）转换成脉冲浓度调制信号（236）的Σ-ΔA/ D转换器（218）。 脉冲密度宽度调制器编码器（222）可操作以将PDM信号编码为PDWM信号（244）。 PDWM具有定义第一和第二位电平的短和长脉冲宽度。 每个脉冲的前沿限制每个脉冲周期。 第二IC（250）包括用于接收PDWM信号的装置（254），可操作以检测PDWM信号的引导脉冲沿的边缘检测器（304），可用于计算每个脉冲周期的时间平均电路 并且在每个脉冲周期的中点附近产生采样脉冲（120），以及锁存器（312），其可操作以采样和保持采样脉冲处的PDWM信号以解码PDM信号（278）。 衬底可操作以支撑第一和第二IC并且在第一和第二IC之间传导PDWM信号。