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公开(公告)号：US07674890B2
公开(公告)日：2010-03-09
申请号：US12080212
申请日：2008-04-01
申请人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
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公开(公告)号：US07439327B2
公开(公告)日：2008-10-21
申请号：US11334081
申请日：2006-01-17
申请人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C. R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子SCFA2，SCFA4或SCFA4v多核苷酸和多肽的药物组合物。 本发明还涉及SCFA2，SCFA4或SCFA4v用于预防或治疗与上皮粘膜退化相关的病症或障碍的治疗用途。
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公开(公告)号：US20080200388A1
公开(公告)日：2008-08-21
申请号：US12080212
申请日：2008-04-01
申请人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
IPC分类号： A61K38/16 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/00 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/00 , C12N5/02
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
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公开(公告)号：US20100278800A1
公开(公告)日：2010-11-04
申请号：US12657731
申请日：2010-01-25
申请人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子SCFA2，SCFA4或SCFA4v多核苷酸和多肽的药物组合物。 本发明还涉及SCFA2，SCFA4或SCFA4v用于预防或治疗与上皮粘膜退化相关的病症或障碍的治疗用途。
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公开(公告)号：US20080300183A1
公开(公告)日：2008-12-04
申请号：US11805883
申请日：2007-05-24
申请人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。 本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。
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公开(公告)号：US20060160738A1
公开(公告)日：2006-07-20
申请号：US11334081
申请日：2006-01-17
申请人： Bryan Boyle , Peter Emtage , Walter Funk , Y. Tang , Jingsong Zhao
发明人： Bryan Boyle , Peter Emtage , Walter Funk , Y. Tang , Jingsong Zhao
IPC分类号： A61K38/18 , C07H21/04 , C12P21/06 , C07K14/475
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子SCFA2，SCFA4或SCFA4v多核苷酸和多肽的药物组合物。 本发明还涉及SCFA2，SCFA4或SCFA4v用于预防或治疗与上皮粘膜退化相关的病症或障碍的治疗用途。
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公开(公告)号：US07732402B2
公开(公告)日：2010-06-08
申请号：US10359935
申请日：2003-02-07
申请人： Bryant Villeponteau , Junli Feng , Walter Funk , William Andrews
发明人： Bryant Villeponteau , Junli Feng , Walter Funk , William Andrews
CPC分类号： C12N15/11 , A01K2217/05 , A61L29/041 , A61L29/14 , A61M25/0045 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Q2600/158 , C12Y207/07049 , C12N2310/3521 , C08L27/18
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译： 包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。
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公开(公告)号：US20090118176A1
公开(公告)日：2009-05-07
申请号：US11991753
申请日：2006-10-06
申请人： Peter C.R Emtage , Walter Funk
发明人： Peter C.R Emtage , Walter Funk
IPC分类号： A61K38/16 , C12N15/00 , A61K31/7088
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00 , C12N2799/022
摘要： Methods for stimulating epithelial cell proliferation and for treating oral and gastrointestinal disorders are described. The methods use compositions comprising stem cell factor-like protein A1 (SCFA1) polypeptides and polynucleotides.
摘要翻译： 描述了刺激上皮细胞增殖和治疗口腔和胃肠道疾病的方法。 该方法使用包含干细胞因子样蛋白A1（SCFA1）多肽和多核苷酸的组合物。
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公开(公告)号：US20050256036A1
公开(公告)日：2005-11-17
申请号：US11046644
申请日：2005-01-27
申请人： Bryan Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Park , Y. Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Park , Y. Tang , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A01K67/027 , A61K38/18 , A61K48/00 , C07K14/475 , C12N15/85 , G01N33/50
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。 本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。
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公开(公告)号：US6013468A
公开(公告)日：2000-01-11
申请号：US520550
申请日：1995-08-29
申请人： William H. Andrews , Ariel Athena Avilion , Junli Feng , Walter Funk , Carol Greider , Maria Antonia Blasco Marhuenda , Bryant Villeponteau
发明人： William H. Andrews , Ariel Athena Avilion , Junli Feng , Walter Funk , Carol Greider , Maria Antonia Blasco Marhuenda , Bryant Villeponteau
IPC分类号： C12N9/12 , C12N15/11 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/11 , C12N15/113 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译： 包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。
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